Cytological Identification of Radiation-Chimæras

Blood cell progenitors: Insights into the properties of stem cells

“…However, transplantation of intact spleens into the abdomen of the lethally irradiated hosts also provided radioprotection (Jacobson et al, 1951b). In 1956, Ford et al (1956 provided definitive evidence that hematopoietic cells and not plasma or subcellular molecules conferred radiation protection. Using donor cells from a strain of mice carrying a balanced (but morphologically identifiable) chromosome translocation, blood cells of a lethally irradiated mouse were demonstrated to be effectively replaced by donor hematopoietic cells after transplantation.…”

Membrana amniótica: fonte alternativa de células-tronco mesenquimais em diversas espécies animais

“…Seu uso foi baseado em estudos antigos das células hematopoiéticas, que ganharam destaque ao se descobrir o poder regenerativo do transplante de medula em ratos (Ford et al 1956). Alguns estudos demonstram novos potencias terapêuticos como no tratamento de doenças neurodegenerativas e metabólicas humanas, como a Doença de Parkinson e a Diabetes Mellitus Tipo 1 (Gavaghan 2001).…”

A Quantitative Study of Bone Marrow Grafting: Implications for Human Bone Marrow Infusion

“…The evidence is quite overwhelming that bone marrow infusions protect by cellular repopulation (see, for example, Loutit, 1954, 1956;Ford et al, 1956;Vos et al, 1956), but there remains some evidence suggesting that a humoral factor may play a small part (Ellinger, 1956 Protection by homologous bone marrow infusion Quantitative data is available for four species (Table V) although the effective marrow dose given for the dog may may not be a minimum dose. It is seen that between 1P2 and 1 7 per cent of the total marrow is required for radiation protec- tioin.…”