Cytological findings of the diffuse sclerosing variant of papillary thyroid carcinoma

Koshikawa, Takashi; Takagi, Nozomi; Hirokawa, Mitsuyoshi

doi:10.5795/jjscc.53.515

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…Diffuse sclerosing variant of papillary thyroid carcinoma (DSVPTC) is an uncommon variant of PTC, characterized by diffuse involvement of one or both lobes of the thyroid gland [ 70 ]. This subtype also presents numerous PBs, so much that Koshikawa et al [ 71 ] included “abundant psammoma bodies” in the list of cytological findings for DSVPTC. In MTC, calcification is a very common US finding and the reported incidences can vary from 20 to 54% [ 72 , 73 ].…”

Section: Calcification In Different Types Of Thyroid Cancermentioning

confidence: 99%

Molecular Aspects of Thyroid Calcification

Ferreira

Gimba

Vinagre

et al. 2020

IJMS

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In thyroid cancer, calcification is mainly present in classical papillary thyroid carcinoma (PTC) and in medullary thyroid carcinoma (MTC), despite being described in benign lesions and in other subtypes of thyroid carcinomas. Thyroid calcifications are classified according to their diameter and location. At ultrasonography, microcalcifications appear as hyperechoic spots ≤ 1 mm in diameter and can be named as stromal calcification, bone formation, or psammoma bodies (PBs), whereas calcifications > 1 mm are macrocalcifications. The mechanism of their formation is still poorly understood. Microcalcifications are generally accepted as a reliable indicator of malignancy as they mostly represent PBs. In order to progress in terms of the understanding of the mechanisms behind calcification occurring in thyroid tumors in general, and in PTC in particular, we decided to use histopathology as the basis of the possible cellular and molecular mechanisms of calcification formation in thyroid cancer. We explored the involvement of molecules such as runt-related transcription factor-2 (Runx-2), osteonectin/secreted protein acidic and rich in cysteine (SPARC), alkaline phosphatase (ALP), bone sialoprotein (BSP), and osteopontin (OPN) in the formation of calcification. The present review offers a novel insight into the mechanisms underlying the development of calcification in thyroid cancer.

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Section: Calcification In Different Types Of Thyroid Cancermentioning

confidence: 99%

Molecular Aspects of Thyroid Calcification

Ferreira

Gimba

Vinagre

et al. 2020

IJMS

View full text Add to dashboard Cite

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Diffuse sclerosing variant of papillary thyroid carcinoma

et al. 2021

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Diffuse sclerosing variant of papillary thyroid carcinoma is a rare variant. This variant is characterized by diffuse fibrosis, calcification, abundant lymphocytic infiltration and psammoma bodies. This variant is usually seen in female patients in the second decade and has an associated chronic thyroiditis. The sonographic findings of diffuse involvement without an obvious mass in the thyroid make it often misdiagnosed as chronic thyroiditis.The treatment is total thyroidectomy, which is similar to high-risk papillary cancer, but since there are many cases with lymph node metastasis in the lateral neck, modified neck dissection is often performed. Here, we performed total thyroidectomy and modified neck dissection in two young women and added radioiodine isotope therapy postoperatively. Although the observation period was short, no recurrence was observed in either case.

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Cytological findings of the diffuse sclerosing variant of papillary thyroid carcinoma

Cited by 2 publications

References 20 publications

Molecular Aspects of Thyroid Calcification

Molecular Aspects of Thyroid Calcification

Diffuse sclerosing variant of papillary thyroid carcinoma

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