Cytological findings in transrectal aspiration biopsy on hormone- and radio-treated carcinoma of the prostate

Abstract

The study reports cytological findings in 63 cases of radio- and/or oestrogen-treated carcinoma of the prostate. The different effects of therapy on the tumor cells in the cytological smear are described and discussed. An evaluation of the results, depending on the type of therapy, showed, that radio-treated tumors, due to the rapid and strong sclerosis of connective tissue, were less suitable for aspiration biopsy than hormone-treated tumors. Further, we were able to show that the effect of therapy in well-differentiated tumors is better than in poorly differentiated tumors. Cytological examination of treated prostate carcinoma is a simple method, quickly carried out, repeatable several times, and of high diagnostic value. Aspiration biopsy is most of all indicated for follow-up of the less well-differentiated and the hormone-treated carcinomas.

Human prostatic adenocarcinoma: Comparative experimental treatment of the tumor line pc 82 in nude mice

“…The histological pattern of regression is marked after two weeks of treatment. The resulting changes, such as widened acinar lumina, reduced epithelial height, and vacuolized cytoplasm, are comparable to features of treated prostatic carcinomas in patients [33,34]. As shown in long-term studies, of castration, periods up to 75 days or transplantation of PC 82 into female [ l ] or castrated male mice, PC 82 does not develop a hormone-independent subline under androgen withdrawal and thus may be superior in this regards to the Dunning 3227 rat prostatic carcinoma [35].…”

The continuing role of fine-needle aspiration of the prostate gland into the 21st century: A tribute to Torsten Löwhagen

“…Several authors [9][10]18,27,30,39,[42][43]47,49,55 have used FNA of the prostate to evaluate the response to hormonal treat-ment. Leinstenschneider and Nagel 39 established six grades of regression and Andersson established four grades.…”

Prognostic Significance of Transrectal Fine-Needle Aspiration Biopsy Findings after Orchiectomy for Carcinoma of the Prostate

“…Later, this method was used in the follow-up of oestrogen-treated patients [5], Spieler et al [16], Kurth et al [10], and Leistenschneider and Nagel [12] reported a prognostic value in cytomorphologic studies on biopsy specimens after oestrogen as well as irradiation treatment of prostatic carcinoma.…”