Cytological Diagnosis of Cancer: Its Uses and Limitations

Boddington, Michael M.; Spriggs, A. I.

doi:10.1136/bmj.1.5449.1523

Cited by 12 publications

(7 citation statements)

References 24 publications

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“…The yield of malignant cells in pleural fluids was low (34%) and compares unfavourably with the 54% of Boddington and Spriggs (1965). Pleural needle biopsy gave only 38% positive results, partly because satisfactory portions of pleura were not always obtained; Donohue, Katz, and Matthews (1958) obtained 38% positives from a similar series.…”

Section: Bronchoscopic Findingsmentioning

confidence: 97%

The diagnosis of primary lung cancer with special reference to sputum cytology

Oswald¹,

Hinson²,

Canti³

et al. 1971

Thorax

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Of 2,545 in-patients with primary lung cancer, pathological proof of the diagnosis was obtained by sputum cytology in 48%, by bronchoscopy in 32%, by biopsy from miscellaneous sites in 12%, and at thoracotomy or necropsy only in 19%. The diagnosis was made solely on clinical and radiological evidence in 8%.One or more satisfactory specimens of sputum from 2,035 patients gave a positivity rate of 59%. When three specimens of sputum were tested the positivity rate was 69% and when four or more were tested, 85%. The maximum false positivity rate was 0-7%. Agreement between the types of malignant cells found in the sputum and in resected or necropsy specimens occurred in 84%. The pathological diagnosis was based solely on sputum cytology in 40% of the patients in whom malignant cells were found in the sputum.The total work of the sputum laboratories was analysed for one year (1967); sputum was examined from 1,598 patients, of whom 266 (17%) had positive results.Of 1,518 patients who had a bronchoscopy, the positivity rate was 53%, and of 524 patients with biopsies from miscellaneous sites the rate was 64%.Sputum cytology, as practised at present, is a very valuable method of diagnosis, but its demands on time and expertise make it unsuitable for general application outside large medical centres. Bartholomew's Hospital and 29 from Brompton Hospital could not be traced.Notes from a total of 2,545 patients were available for study, 913 from St. Bartholomew's and 1,632 from Brompton. There were 2,176 males and 369 (14%) females. One or more specimens of sputum were submitted for cytological investigation from 2,035 (80%) of the patients, bronchoscopy was performed in 1,518 (60%), and biopsies were taken from other sites in 524 (21%). Lung resection was performed in 1,002 (39%) and a further 199 (8%) (1-1%)The miscellaneous group included 10 bronchiolo-623 on 9 May 2018 by guest. Protected by copyright.

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Section: Bronchoscopic Findingsmentioning

confidence: 97%

The diagnosis of primary lung cancer with special reference to sputum cytology

Oswald¹,

Hinson²,

Canti³

et al. 1971

Thorax

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“…These techniques include Millipore filtration, differential centrifugation, cytocentrifugation and or addition of hemolyzing chemicals to the fluids and are useful for processing fluids from varied sources such as pericardial, pleural, peritoneal and hemorrhagic tumor aspirates. [1][2][3] The common goal of each technique is selection and concentration of an adequate number of tumor cells with intact cell morphology without losing them during processing. The cell morphology should remain well preserved so that a correct interpretation of tumor type may be possible.…”

Section: Discussionmentioning

confidence: 99%

Cytologic Examination of Hemorrhagic Fluid by Capillary Centrifugation

Agarwal

2009

Acta Cytologica

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“…Also, the possibility of contamination from other parts of the urinary tract cannot be discounted. It is of no value in latent or occult carcinoma (6,13,22), though some authors have been highly successful in the diagnosis of prostatic carcinoma by this method (16). Popular concensus of opinion agrees that 85-950/o of prostatic carcinomas arise in the periphery of the gland, either capsular or subcapsular.…”

Section: Transurethral Biopsies and Silvermanmentioning

confidence: 99%

Fine Needle Aspiration Biopsy of the Prostate

Rheinfrank¹,

Nulf²

1969

Endoscopy

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A preliminary rcport is submitted on the aspiration biopsy of the prostatic gland.A technique of prostatic biopsy is described, being relatively free of complications and readily accepted by patients as an office procedure for routine screening for carcinoma of the prostate.A modification of the Giemsa staining technique is performed so as to evidence pathognomic elements within the interior of the nucleus, specifically in the altered nucleolus.Endoscopy 1 (1969) 27-32

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Cytological Diagnosis of Cancer: Its Uses and Limitations

Cited by 12 publications

References 24 publications

The diagnosis of primary lung cancer with special reference to sputum cytology

The diagnosis of primary lung cancer with special reference to sputum cytology

Cytologic Examination of Hemorrhagic Fluid by Capillary Centrifugation

Fine Needle Aspiration Biopsy of the Prostate

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