Cytological diagnosis of angiomatoid fibrous histiocytoma: Report of a case and review of literature

Abstract

Angiomatoid fibrous histiocytoma (AFH) is an unusual superficially located tumor primarily affecting children and young adults. It grows slowly and most often occurs on the extremities. There is a paucity of literature on the cytological findings of AFH owing to the rarity of the lesion and its superficial location which makes it easier to perform the biopsy. Here, we present a case of AFH in a 7‐year‐old girl who presented with a left upper arm swelling. The cytology of this tumor along with histopathologic correlation and review of literature is discussed.

Angiomatoid Fibrous Histiocytoma: Case Presentation with Review of Literature

“…Angiomatoid Fibrous Histiocytoma is a rare tumor that was first described by Enzinger in 1979 [1]. It was originally believed to be quite an aggressive neoplasm with uncertain histogenesis, mainly affecting children and young adults, and often involving superficial soft tissues of the extremities [2], although rare cases have been reported in other locations, such as intracranial [3][4][5], spinal [6] or chest wall [7]. In terms of prevalence, AFH accounts for 0.3% of all soft tissue cancers [2] and is classified by the World Health Organization (WHO 2020) as a mesenchymal neoplasm of uncertain differentiation and intermediate malignant biological behavior.…”