2020
DOI: 10.1111/cyt.12832
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Cytological diagnosis of a rare synchronous non‐small cell lung cancer metastatic to the thyroid gland

Abstract: A rare case of synchronous metastatic lung adenocarcinoma to the thyroid gland, diagnosed on routine fine‐needle aspiration cytology, is described. The combined use of morphological features associated with immunocytochemical analysis on smeared specimens as well as on cell‐block material, is a feasible tool to achieve a definitive diagnosis and it also permits determination of the required biomarkers.

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Cited by 2 publications
(2 citation statements)
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“…EGFR and EML4-ALK gene mutations are associated with thyroid metastasis of lung cancer, but the exact mechanism is not clear [ 33 ]. The combined use of morphological fine-needle aspiration biopsy (FNAB) features with immunohistochemistry (IHC) analysis of adequate cell content on smeared specimens, as well as on cell-block material, is a feasible and reliable method to achieve a definitive diagnosis of metastatic nonsmall cell lung cancer to the thyroid gland [ 35 ]. In terms of prognosis, the prognosis of patients with adenocarcinoma was significantly better than that of patients with squamous cell carcinoma or other histological types [ 36 ].…”
Section: The Primary Tumormentioning
confidence: 99%
“…EGFR and EML4-ALK gene mutations are associated with thyroid metastasis of lung cancer, but the exact mechanism is not clear [ 33 ]. The combined use of morphological fine-needle aspiration biopsy (FNAB) features with immunohistochemistry (IHC) analysis of adequate cell content on smeared specimens, as well as on cell-block material, is a feasible and reliable method to achieve a definitive diagnosis of metastatic nonsmall cell lung cancer to the thyroid gland [ 35 ]. In terms of prognosis, the prognosis of patients with adenocarcinoma was significantly better than that of patients with squamous cell carcinoma or other histological types [ 36 ].…”
Section: The Primary Tumormentioning
confidence: 99%
“…The commonly used methods for the diagnosis and prognosis of cancers are (1) imaging examination: including X-ray, CT, magnetic resonance imaging (MRI), ultrasound, endoscopy, glucose metabolism technology and positron emission tomography (PET), radionuclide imaging examination and other imaging methods [ 3 , 4 , 5 ]; (2) molecular marker examination: including detection of tumor markers such as carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), and various carbohydrate antigens (such as CA125 and CA19) and some tumor-related biochemical indicators such as acid phosphatase (ACP), estrogen receptor (ER), and progesterone receptor (PR) in serum urine of patients [ 4 , 6 , 7 , 8 , 9 ]; (3) pathological examination where the abnormal tissue samples are collected for pathological examination by techniques such as immunohistochemistry (IHC), HE staining, and fluorescence in situ hybridization (FISH) [ 10 , 11 ]; (4) detection of circulating tumor cells (CTC), such as detection of tumor cells in peripheral blood, which can be used to monitor and predict the prognosis of tumor metastasis [ 12 , 13 ]; (5) body fluid cytological diagnosis, including detection of tumor cells by sputum, urine and other liquids or by means of puncture [ 14 , 15 ]; and (6) other examinations: including digital rectal examination (DRE), fecal occult blood test (FOBT), and other diagnostic methods [ 16 , 17 ].…”
Section: Introductionmentioning
confidence: 99%