Cytological Correlation in Patients Who Have a Pre‐diagnosis of Thyroiditis Ultrasonographically

Aydın, Özlem; Apaydın, Feramuz Demir; Bozdogan, R; Pata, Cengiz; Yalçınoglu, O.; Kanık, Arzu

doi:10.1081/erc-120018680

Cited by 9 publications

(11 citation statements)

References 11 publications

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“…The inflammatory diseases of the thyroid gland are classified into three groups, that is, acute, subacute and chronic. [ 3 8 ] De Quervain's thyroiditis, also named giant-cell or granulomatous thyroiditis, is the subacute inflammation of the thyroid and constitutes nearly 3–6% of all thyroid diseases. [ 1 3 4 ] It is a nonspecific inflammation that generally appears 2 weeks after a viral upper respiratory tract infection and regresses spontaneously within 2–3 months.…”

Section: Discussionmentioning

confidence: 99%

Subacute granulomatous (De Quervain's) thyroiditis: Fine-needle aspiration cytology and ultrasonographic characteristics of 21 cases

et al. 2015

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Background:Subacute granulomatous thyroiditis (SGT) is an inflammatory disease that presents with different clinical and cytological characteristics. Although the diagnosis is generally made clinically, imaging methods and fine-needle aspiration (FNA) may provide assistance, particularly in atypical cases. The objective of this study is to reveal the ultrasonographic (USG) and cytological characteristics of SGT.Materials and Methods:The clinical, USG and cytological findings of 21 cases diagnosed with SGT were reviewed.Results:Ultrasonographic data was available in 20 cases. A hypoechoic thyroid nodule with irregular margins was detected in 12 of the 20 total cases. Of these, 9 cases complained about pain in the thyroid lodge and generally had unilateral lesions, heterogeneous and hypoechoic areas with indistinct margins, rather than nodular lesions, which were seen in 7 cases. Cytologically, the multinuclear giant cells (MNGCs) found in all cases were accompanied by a dirty background containing varying numbers of granulomatous structures, including isolated epithelioid histiocytes, proliferated/regenerated follicle epithelium cells and inflammatory cells and colloid.Conclusion:Though hypoechoic and heterogeneous areas with irregular margins are strongly associated with thyroiditis, SGT may also appear as painful or painless hypoechoic, solid nodules and generate challenges in differential diagnosis. Although the most remarkable characteristic observed in FNA cytology was the presence of multiple MNGCs with cytoplasm, a dirty background accompanied by mild-moderate cellularity, degenerated-proliferated follicular epithelium cells, rare epithelioid granulomas and mixed type inflammatory cells are characteristic for SGT. The assessment of these radiological and cytological findings in conjunction with clinical findings will assist in the achievement of an accurate diagnosis.

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Section: Discussionmentioning

confidence: 99%

Subacute granulomatous (De Quervain's) thyroiditis: Fine-needle aspiration cytology and ultrasonographic characteristics of 21 cases

et al. 2015

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“…The radiological-cytopathological correlation was an important tool in these cases. Aydin et al (11) showed that the true diagnosis rate of thyroiditis was increased up to 81.8% when US-guided FNAB was performed, while it was 4.5% with using only the clinical and laboratory findings.…”

Section: Discussionmentioning

confidence: 99%

Ultrasonographic Characteristics of Subacute Granulomatous Thyroiditis

Park

Kim

et al. 2006

Korean J Radiol

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ObjectiveWe wanted to describe the characteristic ultrasonography (US) features and clinical findings for making the diagnosis of subacute granulomatous thyroiditis.Materials and MethodsA total of 31 lesions from 27 patients were confirmed as subacute granulomatous thyroiditis by US-guided fine needle aspiration biopsy. We analyzed the ultrasonographic findings such as the lesion's size, margin and shape, the discrepancy between length and breadth and the vascularity. The clinical findings such as acute neck pain or fever were reviewed. The follow-up clinical and ultrasonographic data were reviewed for 15 patients.ResultsThe thyroid gland was found to be enlarged in five patients, it was normal size in 20 patients and it was smaller in two patients. All the lesions had focally ill-defined hypoechogenicity. Hypervascularity was not noted in any of the lesions. Painful neck swelling was present in 18 patients. An accompanying fever was documented in nine of the 18 patients. Twelve patients showed disappearance (n = 3) or a decreased size (n = 9) of their lesions on follow-up US.ConclusionThe presence of ill-defined hypoechoic thyroid lesions without a discrete round or oval shape is characteristic for subacute granulomatous thyroiditis, and particularly when this is associated with painful neck swelling and/or fever.

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“…Two hundred and fifty-three consecutive patients with Hashimoto's thyroiditis, who were presented to our clinic between April 2002 and January 2004, were recruited. The diagnosis was made through presence thyroid peroxidase antibody (TPO-Ab) and ultrasonographic appearance (Aydin et al, 2003). Thirtyeight patients, who had the diagnosis of diabetes mellitus according to ADA criteria (Gabir et al, 2000), were excluded from the study.…”

Section: Subjectsmentioning

confidence: 99%

Prevalence of Glutamic Acid Decarboxylase Antibody Positivity and its Association with Insulin Secretion and Sensitivity in Autoimmune Thyroid Disease: A Pilot Study

Aksoy¹,

Yürekli²,

Yildiz³

et al. 2006

Exp Clin Endocrinol Diabetes

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Our results suggest that the prevalence GAD-Ab in Hashimoto's thyroiditis is around 5%. GAD-Ab antibody positivity per se does not appear to be associated with any disturbances in insulin sensitivity or insulin secretion in this specific population. The presence of islet-cell autoimmunity does not seem to influence insulin secretion or action in normal glucose tolerant subjects with Hashimoto's thyroiditis in this pilot study. Whether the presence of GAD-Ab per se or along with other antibodies impairs insulin dynamics or predicts the development of diabetes in autoimmune thyroiditis remains to be determined in future studies.

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Cytological Correlation in Patients Who Have a Pre‐diagnosis of Thyroiditis Ultrasonographically

Cited by 9 publications

References 11 publications

Subacute granulomatous (De Quervain's) thyroiditis: Fine-needle aspiration cytology and ultrasonographic characteristics of 21 cases

Subacute granulomatous (De Quervain's) thyroiditis: Fine-needle aspiration cytology and ultrasonographic characteristics of 21 cases

Ultrasonographic Characteristics of Subacute Granulomatous Thyroiditis

Prevalence of Glutamic Acid Decarboxylase Antibody Positivity and its Association with Insulin Secretion and Sensitivity in Autoimmune Thyroid Disease: A Pilot Study

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