Cytological aspiration of intraocular retinoblastoma in an 11-year-old boy

Decaussin, Myriam; Boran, Mojgan Devouassoux‐Shishe; Salle, Monique; Grange, Jean‐Daniel; Patricot, L M; Thivolet‐Béjui, F.

doi:10.1002/(sici)1097-0339(199809)19:3<190::aid-dc7>3.0.co;2-h

Cited by 10 publications

(3 citation statements)

References 12 publications

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“…[ 53 ] Despite the rare use of FNAB in the diagnosis of intraocular tumors, the risk of tumor recurrence in the socket was not increased after enucleation according to the literature. [ 53 54 ] Shields et al . stated some risks of RB dissemination after vitrectomy in eyes with unsuspected RB, in older pediatric patients.…”

Section: Ancillary Studiesmentioning

confidence: 99%

Adult onset retinoblastoma

Sengupta

Pan

Khetan

2016

Indian J Ophthalmol

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Retinoblastoma (RB) is the most common primary malignant intraocular tumor of childhood presenting usually before 5 years of age. RB in adults older than 20 years is extremely rare. A literature search using PubMed/PubMed Central, Scopus, Google Scholar, EMBASE, and Cochrane databases revealed only 45 cases till date. Over the past decade, there has been a significant increase in the number of such reports, indicating heightened level of suspicion among ophthalmologists. Compared to its pediatric counterpart, adult onset RB poses unique challenges in diagnosis and treatment. This article summarizes available literature on adult onset RB and its clinical and pathologic profile, genetics, association with retinocytoma, diagnostics, treatment, and outcomes.

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Section: Ancillary Studiesmentioning

confidence: 99%

Adult onset retinoblastoma

Sengupta

Pan

Khetan

2016

Indian J Ophthalmol

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“…The D-type of retinoblastoma is found more commonly in younger infants less than one year, but the U-type found more frequently in children aged two to four years (9). Notably, only a few cases of retinoblastoma in older children (>10 years of age) have been reported and the clinical diagnosis may be difficult (10). However, cytological aspiration can categorically diagnose suspected intraocular tumours of older children in whom clinical and non-invasive investigations have failed to establish the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Neural tumours of the head and neck

Chindia

Dimba²

2009

E Af Med Jrnl

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Objective: To document the pattern of occurrence of all primary neural tumours arising in the neck and craniofacial region over the period 1982 to 1991. Design: A retrospective study. Setting: Cancer Registry, Nairobi, Kenya. Results: Out of the 289 cases who were identified to have had whole body neural tumours, 225(77.8%) had the lesions distributed in the neck and craniofacial area. While 80% of the neoplasms located in this region were retinoblastomas (mainly occurring in the age group 0 to 4 years), other lesion types occurred in small numbers thus: neurofibromas comprised 12.4%, Schwannomas four per cent, neuroblastomas and neuromas each 0.4%; and extracranial gliomas 2.7%. Overall, the male to female ratio was 1:1 and the site distribution revealed that over 90% of the lesions afflicted the upper face. Conclusion: Neural tumours of the neck and craniofacial region appear generally rare in this population as has been shown elsewhere.

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“…1999). Performing a vitrectomy to identify the cause of a retinal mass without calcification in an 11‐year‐old child may be even more risky (Decaussin et al. 1998).…”

Section: Adverse Reactionsmentioning

confidence: 99%

Fine‐needle aspiration biopsy and other biopsies in suspected intraocular malignant disease: a review

Eide

Walaas

2009

Acta Ophthalmologica

125

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. Ocular oncologists require a strong indication for intraocular biopsy before the procedure can be performed because it carries a risk for serious eye complications and the dissemination of malignant cells. The purpose of this review is to evaluate the extent to which this restricted practice is supported by evidence from previous reports and to outline our main indications and contraindications. The different intraocular biopsy techniques in the anterior and posterior segment are discussed with a focus on our preferred method, fine‐needle aspiration biopsy (FNAB). In the literature, complications are typically under‐reported, which reduces the possibilities of evaluating the risks correctly and of making fair comparisons with other biopsy methods. In FNAB, the exact placement of the needle is critical, as is an accurate assessment of the size of the lesion. Fine‐needle aspiration biopsy is usually not a reliable diagnostic tool in lesions < 2 mm in thickness. It is very advantageous to have a cytopathologist present in the operating theatre or close by. This ensures adequate sampling and encourages repeated biopsy attempts if necessary. This approach reduces false negative results to < 3%. Adjunct immunocytochemistry is documented to increase specificity and is essential for diagnosis and management in about 10% of cases. In some rare pathological processes the diagnosis depends ultimately on the identification of specific cell markers. An accurate diagnosis may have a decisive influence on prognosis. The cytogenetic prognostications made possible after FNAB are reliable. Biopsy by FNA has a low complication rate. The calculated risk for retinal detachment is < 4%. Intraocular haemorrhage is frequently observed, but clears spontaneously in nearly all cases. Only a single case of epibulbar seeding of malignant cells at the scleral pars plana puncture site of transvitreal FNAB has been documented. Endophthalmitis has been reported and adequate standard preoperative preparation is obligatory. An open biopsy is still an option in the anterior segment, but has been abandoned in the posterior segment. Although vitrectomy‐based procedures are becoming increasingly popular, we recommend using FNAB as part of a stepwise approach. A vitrectomy‐assisted biopsy should be considered in cases where FNAB fails. In any adult patient with suspected intraocular malignancy in which enucleation is not the obvious treatment, the clinician should strive for a diagnosis based on biopsy. When the lesion is too small for biopsy or the risks related to the procedure are too great, it is reasonable to be reluctant to biopsy. The standards applied in the treatment of intraocular malignant diseases should be equivalent to those in other fields of oncology. Our view is controversial and contrary to opinion that supports current standards of care for this group of patients.

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Cytological aspiration of intraocular retinoblastoma in an 11-year-old boy

Cited by 10 publications

References 12 publications

Adult onset retinoblastoma

Adult onset retinoblastoma

Neural tumours of the head and neck

Fine‐needle aspiration biopsy and other biopsies in suspected intraocular malignant disease: a review

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