Cytological and Immunohistochemical Diagnosis of Canine Transmissible Venereal Tumours

Chandravathi, T.; Kumar, Amit; Reddy, Y. Narasimha; Samatha, V.

doi:10.29005/ijcp.2017.9.2.169-171

Cited by 2 publications

(4 citation statements)

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“…Malignant tumors had numerous, smaller and irregular AgNORs, dispersed throughout the nucleus whereas benign tumors had large, round, sharply defined and few AgNOR dots confined to the nucleoli. These findings were in accordance with the findings made by Crocker et al [24], Chandravathi et al [25] and Veena et al [26]. In contrary, Sandhya et al [25] observed small, homogenously stained, regular AgNORs in benign tumors (papillomas) and large irregular dots or bizzare clusters in malignant tumors (SqCC).…”

Section: Discussionsupporting

confidence: 79%

“…These findings were in accordance with the findings made by Crocker et al [24], Chandravathi et al [25] and Veena et al [26]. In contrary, Sandhya et al [25] observed small, homogenously stained, regular AgNORs in benign tumors (papillomas) and large irregular dots or bizzare clusters in malignant tumors (SqCC). Variations in the size and number of the AgNOR dots might depend on the stage of the cell cycle, the transcriptional and metabolic activity of the cell or the number of NOR-bearing chromosomes in the karyotype [27].…”

Section: Discussionsupporting

confidence: 79%

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Nucleolar Organizer Region Count, PCNA and Ki-67 Indices are Diagnostic Markers of Malignancy and Cell Proliferation Rate in Bovine Lymphosarcoma

PJ¹,

Sujatha²

2016

J Veterinar Sci Technol

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Lymphoid tumors comprise one of the most common groups of tumors in domestic animals. Lymphosarcoma is expressed as a specific multicentric form in calvesupto six months of age (sporadic) and in adult cattle (enzootic); and as thymic form in young cattle. Eight calves of both sexes aged below six months were necropsied in the department of veterinary Pathology, college of Veterinary Science, Tirupati. During necropsy impression smears, represented tissue samples were collected for Cytopathology, histopathology, AgNOR count and immunohistochemical studies. Cytological smears revealed lymphocytes, prolymphocytes and lymphoblasts with anaplastic changes. Histopathologically, partial to complete obliteration of architecture due to the replacement of normal tissue by lymphoblastic cells in lymphnodes and other visceral organs. The mean AgNOR count of the lymphosarcoma was 4.25 and it appear as a round to irregular, dark brown to black dots of varying sizes in the nuclei. Positive expression of PCNA and Ki67 was noticed in lymphnode, liver, kidney and lung was observed. The labeling index of PCNA and Ki-67 expression and distribution of immunopositive cells may be helpful in the early diagnosis and prognosis of malignant tumors. Hence, AgNOR, PCNA and Ki-67 indices can be used as reliable markers of cell proliferation and malignancy.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 79%

Nucleolar Organizer Region Count, PCNA and Ki-67 Indices are Diagnostic Markers of Malignancy and Cell Proliferation Rate in Bovine Lymphosarcoma

PJ¹,

Sujatha²

2016

J Veterinar Sci Technol

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“…The patient data including breed, age, sex, anatomical location of the tumor, size, and ulcerations in tumor was noted. FNAC was conducted for the non-ulcerated suspected masses as per Cowell et al (2007) [12] with the help of a fine needle (22G) and the impression smears of the superficial ulcerated mass were made following staining with Giemsa stain (Thangathurai et al, 2008) [41] . Cytologically, smears were analyzed under optical microscope and CTVT cells are characterized on the basis of predominant cell type as described by Amaral et al (2007) [15] as lymphocytoid, plasmacytoid, mixed forms.…”

Section: Methodsmentioning

confidence: 99%

“…CTVT (Canine Transmissible Venereal Tumour) is one of the most important round-cell tumours in dogs. Other names for CTVT include sticker tumour, infectious sarcoma, transmissible lymphosarcoma, and venereal granuloma (Thangathurai et al, 2008) [41] . Using this tumor, Novinsky reported the first successful experimental tumour transplant (Murgia et al, 2006) [30] .…”

Section: Introductionmentioning

confidence: 99%

An epidemiological study and Cytomorphological characterization of canine transmissible venereal tumor (CTVT)

Srivastav,

Prabhu,

Gangwar

et al. 2024

Int. J. Adv. Biochem. Res.

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The contagious venereal tumour also known as canine transmissible venereal tumor (CTVT) is most often found in dogs that live in close proximity to one another or in stray and wild canines who engage in unrestricted sexual behavior. This study aimed to investigate the epidemiological aspects of CTVT and its characterisation based on the cytomorphology. A total of 118 tumorous samples from dogs were collected at the Veterinary Clinical Complex (VCC), DUVASU, Mathura, and studied in the Department of Veterinary Pathology, DUVASU, and Mathura. The distribution of CTVT in terms of age, sex, and breed was evaluated. CTVT accounted for 38.13% of all tumours in dogs, with predominant occurrences in females (68.9%), non-descript breeds (44.45%), and dogs aged between 2-8 years (73.34%). Genital presentations comprised 77.77% of cases, with extragenital regions also affected. Cytological examination revealed various forms of CTVT, including lymphocytoid, plasmacytoid, and mixed forms, with lymphocytoid forms primarily localized in genital locations. Plasmacytoid forms were prevalent in extragenital sites, particularly in dogs over 7 years of age. Histopathological examination exhibited sheets of round to ovoid tumorous cells, mitotic figures, and hyperchromatic nuclei with sparse fibrous stroma. This study underscores the significance of epidemiology and cytology in understanding the diagnosis of Canine Transmissible Venereal Tumor (CTVT).

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Cytological and Immunohistochemical Diagnosis of Canine Transmissible Venereal Tumours

Cited by 2 publications

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Nucleolar Organizer Region Count, PCNA and Ki-67 Indices are Diagnostic Markers of Malignancy and Cell Proliferation Rate in Bovine Lymphosarcoma

Nucleolar Organizer Region Count, PCNA and Ki-67 Indices are Diagnostic Markers of Malignancy and Cell Proliferation Rate in Bovine Lymphosarcoma

An epidemiological study and Cytomorphological characterization of canine transmissible venereal tumor (CTVT)

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