Cytologic picture of Castleman′s disease: A report of two cases

Sudha, Ayyagari; Vivekanand, N

doi:10.4103/0970-9371.73306

Cited by 14 publications

(13 citation statements)

References 7 publications

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“…CD is a rare cause of lymphadenopathy which commonly involves the mediastinal and cervical nodes, and can be localized or multicentric [ 1 , 6 ]. There are two distinct histopathological variants of CD - hyaline vascular and plasma cell type.…”

Section: Discussionmentioning

confidence: 99%

“…FNAC, which is otherwise a well-established diagnostic modality for lymphadenopathies, lacks a clearly defined role in CD [ 5 ]. Only a few reports in the literature highlight the cytological features of hyaline vascular type of CD [ 1 - 3 , 5 ]. Plasma cell type has non-specific cytological features and is therefore extremely difficult to diagnose on cytology.…”

Section: Discussionmentioning

confidence: 99%

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Hyaline Vascular Type of Castleman Disease: Diagnostic Pitfalls on Cytology and Its Clinical Relevance

Singh¹,

Chowdhury²,

Pal³

et al. 2021

Cureus

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Castleman disease (CD) is an uncommon cause of lymphadenopathy. The role of fine-needle aspiration cytology (FNAC) as a diagnostic modality in this disease is not well established. Cytological features of CD have a considerable overlap with many reactive conditions. It has subtle morphological features; which if overlooked, may miss the diagnosis. A two-year-old girl presented with cervical lymphadenopathy. FNAC of the cervical lymph node showed features of granulomatous lymphadenitis. Excision biopsy revealed the hyaline vascular type of CD. Cytological smears were reviewed carefully and revealed indicators of CD. These included capillary fragments with adherent reactive lymphoid cells, plump endothelial cells and pale pink material admixed with germinal center cells. The collections of plump endothelial cells had been misinterpreted as granulomas previously. This report highlights the subtle cytomorphological pointers of CD. Careful scrutiny for these features could aid the cytologist in differentiating CD from other reactive and neoplastic disorders, thus avoiding cytodiagnostic pitfalls. This case study reiterates an important fact that for a lymph node lesion, histopathology plays a crucial role in differentiating mimickers and renders an accurate diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hyaline Vascular Type of Castleman Disease: Diagnostic Pitfalls on Cytology and Its Clinical Relevance

Singh¹,

Chowdhury²,

Pal³

et al. 2021

Cureus

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“…In our case, ultrasound and CT scan evoked the tuberculosis origin as a first diagnosis. Since cytological appearances vary depending on the type and extent of hyperplasia, fine needle aspiration cytology (FNAC) findings may not always be conclusive in all cases [ 13 ]. Even in our case, the two FNAC performed were non-contributive.…”

Section: Discussionmentioning

confidence: 99%

Castelman's disease of the neck: a case report and literature review

Korbi¹,

Jellali²,

Jguiri³

et al. 2020

Pan Afr Med J

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Castleman’s disease is a rare pathology, poorly understood. It is considered as a lymphoproliferative disorder, described for the first time in 1954, which may be confused with other causes of lymphadenopathy. We report in this paper the case of a young women presenting with left latero-cervical lymphadenopathy. All the investigations were negative except a large high-vascularized level II cervical lymphadenopathy. We performed a cervicotomy. The extemporaneous histological exam was non-contributive. We decided to perform a complete level II and III left cervical lymphadenectomy. The diagnosis of unicentric Castleman's disease was confirmed based on the final histological study of the specimen, and the absence of other cervical and extra-cervical lymphadenopathy. The patient is free of recurrence at the time of reporting this article.

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“…An excision biopsy maintains the germinal centre and the interfollicular zone which is essential for an accurate diagnosis. 9 Usually the hyaline vascular type of Castleman's disease is completely cured by excision biopsy (comprising most unicentric disease), with no known cases of recurrence documented in the literature. The plasma cell type showed one case of recurrence reported by Sanz et al in a case of Castleman's disease in the head and neck region.…”

Section: Discussionmentioning

confidence: 99%

Unicentric Castlemans disease presenting as a neck swelling: a case report

Ravishankar

Subramanian

2019

Int Surg J

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Castleman's disease is an uncommon entity which is characterized by lymphadenopathy either at a single focus or at multiple sites.Due to the similar clinical picture of other disorders including tuberculous lymphadenitis, lymphoma and other cases of generalized lymphadenopathy like AIDS a diagnosis of castlemans disease. The unicentric form may resemble any generalized swelling such as a lipoma. In this case we discussed an 18 yr old girl presenting with a large neck swelling in the posterior triangle which clinically resembled a lipoma. The CT showed a uniformly enhancing homogenous lesion. After an excision biopsy, the histopathology revealed it to be castleman's disease of the hyaline vascular type. The literature reveals that although rare castlemans disease can be unicentric or multicentric and can involve multiple sites including the axilla, mediastinum and retroperitoneum. Most cases of the unicentric disease are completely cured with an excision biopsy. The multicentric disease may need chemotherapy, radiation or immunomodulating drugs. In conclusion, one must keep a differential of castlemans disease in mind when presented with any case of lymphadenopathy.

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Cytologic picture of Castleman′s disease: A report of two cases

Cited by 14 publications

References 7 publications

Hyaline Vascular Type of Castleman Disease: Diagnostic Pitfalls on Cytology and Its Clinical Relevance

Hyaline Vascular Type of Castleman Disease: Diagnostic Pitfalls on Cytology and Its Clinical Relevance

Castelman's disease of the neck: a case report and literature review

Unicentric Castlemans disease presenting as a neck swelling: a case report

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