Cytologic Grading of Fine Needle Aspirates of Breast Carcinoma by Private Practice Pathologists

Rs, Cajulis; Rg, Hessel; Frias‐Hidvegi, Denise; Guo, Yu

doi:10.1159/000332518

Cited by 10 publications

(13 citation statements)

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“…The inter observer and the intra observer reproducibilities are the key factors in any grading system [14]. Because the neoadjuvant therapy, which includes the preoperative chemotherapy and Tamoxifen, is becoming increasingly common for the treatment of early breast cancer, it is desirable to grade the tumours before surgery, so that the most appropriate medical regimens can be selected [15].…”

Section: Resultsmentioning

confidence: 99%

The Cytological Grading of Malignant Neoplasms of The Breast and Its Correlation With The Histological Grading

Vasudev¹

2013

JCDR

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Background and Objectives: Breast carcinoma is one of the leading causes of malignancy in females. The diagnosis of breast carcinoma is often made by fine needle aspiration cytology. Nuclear grading is an important prognostic factor. It is important to grade breast carcinomas, which will provide valuable information to the treating oncologists to plan their management. The purpose of this study was to compare the cytological grading and typing with the histological grading and typing and the regional lymph node metastasis.Methodology: This retrospective and prospective study was done on 60 cases with malignant and suspicious diagnoses on FNAC, which had histopathological correlations, from January 2004 to December 2007. The cytological grading was done by Robinson's Method and the histopathological grading was done by the modified Scarff Bloom Richardson method. Cytological and histological typings were also done. The statistical analysis was done by using the SPSS software: The Chi square test was used and a contingency tale analysis (cross tabs procedure) was also done. Results:The cytohistological grading correlation was accurate in 7 cases (100%) of grade 1, 22 cases (71%) of grade 3 and 9 cases (42.9%) of grade 2 cancers. The accuracy was 62.7% (P < 0.001). A higher cytological grade was associated with a nodal metastasis. (cc : 0.399, P < .006) The cytological typing was accurate in 44 cases out of the 60 cases. Interpretation and Conclusion:The cytological grade correlated well with the histological grading accuracy (62.7%) and a higher grade was associated with a nodal metastasis (P < 0.006), Hence the cytological grading and typing should be routinely incorporated in the cytology reports and they can be of great value in guiding the choice of the treatment protocols.Vidya VasudeV, Rangaswamy R., geethamani V. InTROduCTIOnBreast cancer is the second most common malignancy in females in India [1]. Recent studies have shown that the incidence of breast cancer is increasing and shifting towards the younger age group [2]. Hence, any breast lump, whether it is benign or malignant, is a source of anxiety for the patient as well as for the treating doctor [3].Breast cancer is a malignant disease with a heterogenous prognosis. Evaluation of the possible prognostic parameters is a growing interest. Assessment of the biological aggressiveness of the cancer without removing it, would be valuable.The value of the histological typing and grading has been well established [4]. Because the neoadjuvant therapy has become increasingly popular as the primary medical treatment of breast cancer, much attention is being focused on grading the tumours, based on the FNA cytology. Such a grading would allow the assessment of the tumour in situ and so the most suitable treatment could be selected before the primary surgery. Also, the morbidity which is associated with the overtreatment of low grade tumours could be avoided [5].FNAB is not only helpful in the diagnosis and the further planning of the treatment, but it is ...

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Section: Resultsmentioning

confidence: 99%

The Cytological Grading of Malignant Neoplasms of The Breast and Its Correlation With The Histological Grading

Vasudev¹

2013

JCDR

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“…Os critérios nucleares mais úteis e comumente utilizados nos sistemas de graduação são a comparação do tamanho do núcleo da célula tumoral com o linfócito maduro ou hemácia, o número de mitoses, a presença e a proeminência de nucléolo e a anisonucleose 17 . O presente trabalho teve como objetivos: aplicar classificações citológicas de graduação tumoral e nuclear nas PAAF e compará-las com os métodos de graduação tumoral e nuclear utilizados na histologia para identificar aquelas que mais concordam com esses graus nos respectivos preparados histológicos.…”

Section: Métodos: a Avaliação Da Concordância Cito-histológica Foi Reunclassified

“…Os sistemas que utilizam duas categorias são considerados simples e práticos, obtendo melhor reprodutibilidade intra e interobservador, além de melhor discriminação terapêutica e prognóstica 9,17 . Nesse estudo, os dois sistemas apresentaram maior concordância.…”

Section: Materiais E Métodosunclassified

“…Alguns estudos têm mostrado que a graduação citológica nos esfregaços de carcinoma de mama correlaciona-se bem com a graduação histológica, sendo altamente reprodutível 7,[8][9][10][11][12][13][14][15][16] . Contudo, a graduação citológica de PAAF de mama não é rotineiramente utilizada 17 . Devido ao fato de terapia neoadjuvante ser utilizada como tratamento primário para carcinoma de mama, a graduação tumoral em aspirados citológicos pode ser útil nos casos de pacientes que receberão radioterapia, quimioterapia e/ou terapia hormonal como tratamento primário 7 .…”

Section: Introductionunclassified

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Sistemas de graduação para carcinoma de mama: estudo comparativo da concordância cito-histológica

Dantas¹,

Santos²,

Filho³

2003

Rev. Bras. Ginecol. Obstet.

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A graduação histológica, a infiltração estromal linfoplasmocitária, a invasão vascular, linfática e sanguínea e a infiltração perineural são alguns dos aspectos morfológicos descritos como de importância prognóstica. Dentre estes, o grau histológico tem sido demonstrado como excelente indicador prognóstico [2][3][4] . A avaliação dos parâmetros morfológicos de significado prognóstico tem sido realizada em espécimes de biópsia incisional ou de exérese de nódulos palpáveis. Os meios diagnósticos vêm-se

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“…This is because of categorizing the breast lesions is limited to benign or malignant groups and no further cytomorphological findings are included in the cytology report to grade the breast cancers. There are several cytological grading methods like Hunt's cytological grading (HCG), Modified Black grading (MBG) and Robinson's cytological grading (RCG) to grade breast cancer [7][8][9] . Masood et al has come out with a unique method (Masood cytology index -MCI) [10] of delineating neoplastic lesions of breast into benign, borderline and malignant breast lesions on FNA smears in lieu with histopathological grading (Table 1).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Breast Neoplastic Lesions by Different Cytology Grading Methods

Rekha¹,

Nandini²

2015

SJCM

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Abstract:Introduction: With the increase in the awareness of breast cancer among women, cases of lump in the breast has increased in outpatient department. Fine needle aspiration cytology (FNAC) is the easy, quick and cost effective technique of evaluating breast lump. Objective: The present study, evaluated and compared the modified Masood's cytology index (MCI) with various other cytology grading methods and histopathology. Result: Modified MCI has over all concordance rate of 86%, sensitivity of 86%, specificity of 50%, positive predictive value (PPV) of 93% and negative predictive value (NPV) of 30%. Multiple regression analysis revealed an r 2 value of 60%, which was significant. The p-value of anisonucleosis, nucleoli and chromatin pattern were 0.001, 0.05 and 0.02 respectively, which was significant (p-value less than 0.05). Conclusion: Modified MCI will help the cytopathologist to accurately delineate both benign and malignant neoplastic breast lesions into respective categories. This in turn will help the treating surgeon to plan the treatment modality of the patients with lump in the breast. The study recommends that modified MCI method to be routinely incorporated for evaluation of all lump in the breast.

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Cytologic Grading of Fine Needle Aspirates of Breast Carcinoma by Private Practice Pathologists

Cited by 10 publications

References 6 publications

The Cytological Grading of Malignant Neoplasms of The Breast and Its Correlation With The Histological Grading

The Cytological Grading of Malignant Neoplasms of The Breast and Its Correlation With The Histological Grading

Sistemas de graduação para carcinoma de mama: estudo comparativo da concordância cito-histológica

Evaluation of Breast Neoplastic Lesions by Different Cytology Grading Methods

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