Cytologic Findings of Epithelioid Angiosarcoma of the Thyroid

Lin, Oscar; Gerhard, Renê; Siqueira, Sheila Aparecida Coelho; Castro, Inês

doi:10.1159/000326994

Cited by 37 publications

(33 citation statements)

References 22 publications

(18 reference statements)

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“…Most FNA descriptions of EAS and EHE in the literature are case reports or small case series [15,16,17,18,19,20,21,22,23,24,25], with the exception of one larger case series on EHE [26]. A cytomorphological study conducted by Liu and Layfield [27] described common features found in 11 AS, but this study did not exclusively examine EAS.…”

Section: Discussionmentioning

confidence: 99%

Cytopathologic Characteristics of Epithelioid Vascular Malignancies

et al. 2014

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Objectives: Epithelioid hemangioendothelioma (EHE) and epithelioid angiosarcoma (EAS) are rare vascular neoplasms that share many morphological characteristics on histology but demonstrate different clinical behavior. Given the many reported clinical and morphological features shared between EAS and EHE, we examined all cases of EAS and EHE diagnosed primarily on fine needle aspiration (FNA) at our three institutions that were confirmed by a tissue diagnosis. Study Design: A total of 29 cases from 25 patients were identified: 15 EHE from 11 patients and 14 EAS from 14 patients. Results: Many cytomorphological features existed on a spectrum that overlapped considerably between EAS and EHE cases. Common features between the two entities include epithelioid morphology and eccentrically placed nucleus. Intracytoplasmic lumens (ICL), a morphological feature that may suggest vascular origin, can be found in both entities but are not always present. Conclusions: Given the general absence of vascular cytomorphological features, such as ICL, the proper classification of these tumors depends on the successful use of immunoperoxidase markers such as factor VIII-related antigen, ERG, or CD31 as well as a high index of suspicion. The distinction between EAS and EHE on FNA alone is treacherous at best.

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Section: Discussionmentioning

confidence: 99%

Cytopathologic Characteristics of Epithelioid Vascular Malignancies

et al. 2014

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“…This degree of positivity is not meaningful to postulate an epithelial origin of these tumors. Furthermore, positivity has also been reported in nonepithelial tumors including synovial sarcoma, 34 epithelioid angiosarcoma, 33 and Wilms' tumor, the latter a neoplasm composed of primitivepluripotential cells. 35 Regarding CK20, we only found CK20 positive cells in two out of 13 MTsV and Skelton and Smith found minimal staining in the neoplasm they studied.…”

Section: Discussionmentioning

confidence: 96%

“…[29][30][31][32][33] The largest immunohistochemical analysis of MTsV reported by Branton and Tavassoli 1 found intense reactivity with AE1/3 in nine out of 10 MTsV, while another tumor only showed sparse reactivity in the stromal-like component that was by far the predominant and in some cases the only component in these tumors. Similar results have been reported by others.…”

Section: Discussionmentioning

confidence: 96%

Mixed tumors of the vagina: an immunohistochemical study of 13 cases with emphasis on the cell of origin and potential aid in differential diagnosis

et al. 2004

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“…Epithelioid angisarcoma (EAS) is a rare subtype of angiosarcoma, and only 18 reported cases exist in the literature describing the cytologic features of this tumor. [6][7][8][9][10][11][12][13][14][15][16] In this letter, such a rare case of EAS of the liver is described.…”

Section: To the Editorsmentioning

confidence: 99%