Cytologic Findings in Noninvasive Intraductal Papillary-Mucinous Carcinoma of the Pancreas

Shimizu, Michio; Hirokawa, Mitsuyoshi; Manabe, Toshiaki; Mikami, Yoshiki; Kanahara, Takuo; Miyake, Yasuyuki; Iwamoto, Sueharu; Tsunoda, Tsukasa

doi:10.1159/000330986

Cited by 21 publications

(22 citation statements)

References 3 publications

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“…No previous reports describe or focus on small papillary cohesive clusters and the cytoplasmic boundary in noninvasive IPMC, irrespective of whether these appeared in the cytologic photomicrographs, [6][7][8][9][10] except that nonloose cell clusters were described in a case report 7 on noninvasive IPMC. The small papillary cohesive clusters observed in this study were found admixed with outer protrusions and were associated with histologic papillary proliferation of IPMC.…”

Section: Discussionmentioning

confidence: 99%

“…The components of invasive IPMC resemble usual invasive ductal adenocarcinoma (IDA) or mucinous, noncystic carcinoma. 2,5 No detailed study of the cytologic diagnosis of invasion has been reported to date, although two reports 6,7 conclude that it is impossible to differentiate noninvasive IPMC and IDA. In the present study, we examined the cytologic features of IPMC with the aim of differentiating it from hyperplasia, invasive IPMC and invasive IDA.…”

Section: Objective: To Examine the Cytologic Features Of Noninvasive mentioning

confidence: 99%

“…Euchromatin was common in the present IPMC series but rare in IDA and hyperplasia. Euchromatin can be recognized in photomicrographs in three reports on IPMC, 6,8,10 but not in reports on IDA. 11,12,18 Thus, euchromatin and mainly small nuclei without anisocytosis appear to be characteristic of IPMC.…”

mentioning

confidence: 91%

“…None of the previously reported cytologic studies described the nuclear size in IPMC cases. [6][7][8][9][10]16,17 In IDA, large nuclei (> 15 µm in diameter) were observed with abundant frequency in most cases (95.8%). Cohen et al reported that nuclei > 15 µm in diameter were seen in 92% of adenocarcinoma smears; however, they were also seen in 28% of benign smears.…”

mentioning

confidence: 99%

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Cytologic Study of Noninvasive Intraductal Papillary-Mucinous Carcinoma of the Pancreas

Hara

Suda

Oyama³

2002

Acta Cytologica

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Section: Discussionmentioning

confidence: 99%

Section: Objective: To Examine the Cytologic Features Of Noninvasive mentioning

confidence: 99%

mentioning

confidence: 91%

mentioning

confidence: 99%

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Cytologic Study of Noninvasive Intraductal Papillary-Mucinous Carcinoma of the Pancreas

Hara

Suda

Oyama³

2002

Acta Cytologica

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“…The clinicopathologic fi ndings are important to determine the surgical strategy. Location of the lesion (main pancreatic duct type), and the presence of mural nodules are highly suggestive of malignancy [8] . Pancreatic juice cytology is also important for the preoperative diagnosis of IPMN.…”

Section: Introductionmentioning

confidence: 99%

Pancreatic juice cytology in IPMN of the pancreas

Yamaguchi

Nakamura²,

Shirahane

et al. 2005

Pancreatology

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Pancreatic juice cytology in the diagnosis of intraductal papillary mucinous neoplasm of the pancreas

Yamaguchi

Shirai

Ishihara

et al. 2005

Cancer

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BACKGROUND The examination of pancreatic juice cytology could hypothetically contribute to the establishment of a definite diagnosis of malignant intraductal papillary mucinous neoplasm of the pancreas (IPMN), but to the authors' knowledge, its significance has not been confirmed to date. The current study was conducted to assess the diagnostic value of pancreatic juice cytology in IPMN and to examine the usefulness of peroral pancreatoscopy (POPS) in sampling pancreatic juice. METHODS The study subjects were comprised of 103 patients with IPMN who underwent surgical resection of pancreatic tumors (adenoma in29 patients, borderline in17 patients, carcinoma in situ in 25 patients, and invasive carcinoma in 32 patients). Pancreatic juice was collected with a catheter in 71 patients and by POPS in 32 patients. Patients with pancreatic carcinoma (n = 81) and chronic pancreatitis (n = 76) also were investigated. RESULTS The cytologic diagnosis was found to be of nondiagnostic value in only one patient with an IPMN, whereas it was of no diagnostic value in 14 of the patients with pancreatic carcinoma (17.3%), a difference that was statically significant (P < 0.001). The location of the IPMN (either in the pancreas or the pancreatic ducts) was not found to significantly affect the diagnostic value of the test. The sensitivity for IPMN was 62.2% when pancreatic juice was collected by POPS, and was 38.2% when it was collected using a catheter. In the case of pancreatic carcinoma, the sensitivity of pancreatic juice cytology was found to be 25.4%, which was significantly lower than that for IPMN when the pancreatic juice was collected by POPS (P < 0.001). CONCLUSIONS Pancreatic juice cytology was found to have better diagnostic value in the patients with IPMNs compared with those with pancreatic carcinoma. POPS was found to be useful for the collection of pancreatic juice. Cancer 2005. © 2005 American Cancer Society.

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Cytologic Findings in Noninvasive Intraductal Papillary-Mucinous Carcinoma of the Pancreas

Cited by 21 publications

References 3 publications

Cytologic Study of Noninvasive Intraductal Papillary-Mucinous Carcinoma of the Pancreas

Cytologic Study of Noninvasive Intraductal Papillary-Mucinous Carcinoma of the Pancreas

Pancreatic juice cytology in IPMN of the pancreas

Pancreatic juice cytology in the diagnosis of intraductal papillary mucinous neoplasm of the pancreas

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