Cytologic Features of Sinus Histiocytosis with Massive Lymphadenopathy

Sinus histiocytosis with lymphadenopathy - a case report

“…The morphological feature of smears of affected lymph node in a patient with SHML includes a histiocytic proliferation with presence of large histiocytes showing fine vacuoles in the cytoplasm and large vesicular nuclei. The phagocytosis of lymphocytes and plasma cell (emperipolesis) is characteristic 11 . The background population predominantly consists of lymphocytes, plasma cells, and neutrophils.…”

Crush Cytology of Rosai-Dorfman Disease of the Central Nervous System

“…However, many authors also commented on the nuclear atypia of the RDD histiocytes, which included nuclear enlargement, nuclear hyperchromatism and nucleolar prominence when compared with the usual histiocytes. 21,24,27,28,30,32,35 CNS RDD is difficult for the pathologist to diagnose, especially during an intraoperative consultation, because it is very difficult to discern the atypical nuclear features and lymphophagocytosis of RDD histiocytes on frozen section slides. Recent progress in cytology has proven the usefulness of crush preparations in cytologic diagnosis, especially in the field of neuropathology.…”

Fine Needle Aspiration Cytology of Dermatopathic Lymphadenitis

“…Rosai-Dorfmann disease often demonstrates the distinguishing finding of lymphophagocytosis (emperypolesis), which can help to identify the lesion when found (Table I). 17 Cytologically, the interdigitating reticulum (IRCs) of DL demonstrate a striking morphologic similarity to LCs in normal skin as well as in LH. These cells also share an identical immunohistochemical phenotype with LCs, both staining positive with CD1a and S-100 protein.…”