Cytologic features of needle aspiration of ovarian sex cord tumor with annular tubules: Report of two cases and literature review

Abstract

Sex cord tumor with annular tubules (SCTAT) is a rare ovarian tumor with characteristic microscopic morphologic features. Diagnosis most often is based on examination of tissue specimens. Cytologic features of this tumor rarely have been described in the English literature. Herein, we report cytologic findings of cyst aspiration fluid in two cases of SCTAT, with cyto-histologic correlation.

Incidental finding of sex cord tumor with annular tubules in ovary associated with Peutz-Jeghers syndrome

“…Sex cord tumors with annular tubules, on the other hand, represent <1% of all sex cord tumors and typically occur in patients in their third or fourth decade of life. [1] This tumor was first reported by Scully in 1970, who described its characteristic histology and association with Peutz-Jeghers syndrome (PJS). [1,5] Sex cord tumors with annular tubules show tubules with Sertoli cells arranged around one or more hyaline bodies.…”

“…[1] This tumor was first reported by Scully in 1970, who described its characteristic histology and association with Peutz-Jeghers syndrome (PJS). [1,5] Sex cord tumors with annular tubules show tubules with Sertoli cells arranged around one or more hyaline bodies. In patients with Peutz-Jeghers syndrome, these tubules may be scattered and mixed with normal ovarian tissue rather than forming a distinct mass.…”

“…[10] Clinical presentations include irregular menstruation, hyperestrinism, the presence of a mass and abdominal/pelvic pain, and in young people there may be sexual precocity. [1,10] The vast majority of patients with SCTAT and PJS also have gastrointestinal polyposis and mucocutaneous melanin pigmentation. [10] Most ovarian SCTAT are benign.…”

“…Sex cord tumor with annular tubules (SCTAT) is a rare type of sex cord stromal tumor, which differs from other tumors in its histomorphology. [1] Approximately one third of SCTAT are associated with Peutz-Jeghers syndrome (PJS). [1,2] PJS is a rare autosomal dominant disease with no gender preference, [3] characterized by multiple hamartomatous polyps in the gastrointestinal tract associated with mucocutaneous melanic pigmentation.…”

“…[1] Approximately one third of SCTAT are associated with Peutz-Jeghers syndrome (PJS). [1,2] PJS is a rare autosomal dominant disease with no gender preference, [3] characterized by multiple hamartomatous polyps in the gastrointestinal tract associated with mucocutaneous melanic pigmentation. Patients with PJS have an increased risk of other neoplasms involving the gastrointestinal tract, breast, female genital tract, testis, and pancreas.…”