Cytologic Features of Hidradenoma in Fine Needle Aspiration Biopsies

Dubb, Michelle; Michelow, Pam

doi:10.1159/000325121

Cited by 15 publications

(14 citation statements)

References 6 publications

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“…They are often diagnosed on FNA but a precise diagnosis is usually made after excision biopsy and histopathologic evaluation. Occasionally, these cases are referred for FNAC by default for the investigation of a lesion in the skin or subcutaneous tissue [1]. The present study reaffirms that skin adnexal tumors are rare as they accounted for only of 0.22% of the total cases that presented for FNAC, and constituted only 3.5% of the cases with superficial skin swellings.…”

Section: Discussionsupporting

confidence: 80%

“…These syndromic adnexal tumors serve as the markers for internal malignancies and may also indicate an early incidence of malignancy [1]. …”

Section: Resultsmentioning

confidence: 99%

“…In the literature there are limited case reports describing the cytological features of nodular hidradenoma [7,8,9,10,11]. According to Dubb and Michelow [1], all the aspirate from nodular hidradenomas showed a distinct epithelial cell component arranged as clusters, sheets and tubules. Cytologically, these cells resembled ductal cells which were bland with round-to-oval nuclei, vesicular chromatin and small inconspicuous nucleoli.…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic Evaluation of Skin Adnexal Tumors by Fine-Needle Aspiration Cytology

Chand

Khare²,

Gupta³

et al. 2016

Acta Cytologica

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Background: The diagnosis of skin adnexal tumors is usually based on histopathology. However, fine-needle aspiration cytology (FNAC) can be of great help and shows a high degree of correlation to the final diagnosis. It is helpful in many situations where skin lesions are a manifestation of certain systemic syndromes and aids to the formation of precise treatment plans. Materials and Methods: This prospective study was carried out to assess the diagnosis of skin adnexal tumors based on FNAC and their comparison with histopathological diagnoses. There were 14 patients with FNAC and histopathological follow-up in whom a final diagnosis of skin adnexal tumor was made. The results of FNAC were compared with histopathological diagnoses for complete correlation, partial correlation (cases where an FNAC diagnosis of skin adnexal tumor was made but a precise diagnosis of the subtype was not possible) or no correlation (where FNAC failed to diagnose a skin adnexal tumor). Results: Among the 14 cases of skin adnexal tumor, there was total correlation between the FNAC diagnosis and final histopathological diagnosis in 8 cases (57.1%) and a partial correlation in 4 cases (28.5%). There was no correlation of the FNAC diagnosis with the histopathological diagnosis in only 2 cases (14.3%). Conclusions: FNAC is very useful in making a diagnosis of skin adnexal tumors and helps in the management of the patient.

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Section: Discussionsupporting

confidence: 80%

“…These syndromic adnexal tumors serve as the markers for internal malignancies and may also indicate an early incidence of malignancy [1]. …”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Diagnostic Evaluation of Skin Adnexal Tumors by Fine-Needle Aspiration Cytology

Chand

Khare²,

Gupta³

et al. 2016

Acta Cytologica

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“…Although the cytology of atypical hidradenomas has never previously been described, cytologic findings are well-characterized in both benign and malignant hidradenomas [14,15,16,27,28,29,30,31]. Aspirates of benign hidradenomas exhibit tissue fragments and clusters of polygonal-to-elongated cells with moderate amounts of basophilic-to-clear cytoplasm, well-defined cell borders and tubule formation with homogenous eosinophilic luminal secretions [14,15,27,28].…”

Section: Discussionmentioning

confidence: 99%

“…Aspirates of benign hidradenomas exhibit tissue fragments and clusters of polygonal-to-elongated cells with moderate amounts of basophilic-to-clear cytoplasm, well-defined cell borders and tubule formation with homogenous eosinophilic luminal secretions [14,15,27,28]. Indeed, some authors have contended that these cytomorphologic features are, in sum, specific to hidradenomas [30].…”

Section: Discussionmentioning

confidence: 99%

Atypical Hidradenoma Mimicking Primary Mammary Carcinoma on Breast Fine-Needle Aspiration: A Case Report with Long-Term Follow-Up

Rooper

Iding

Cuda³

et al. 2016

Acta Cytologica

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Background: Fine-needle aspiration (FNA) is well-established as an accurate technique for the diagnosis of palpable breast masses. While the differential diagnosis of such lesions usually focuses on benign or malignant mammary proliferations, a subset of breast neoplasms arises from skin and soft tissue. Skin adnexal neoplasms such as hidradenoma can pose a particular pitfall on breast FNA cytology (FNAC) as epithelial proliferations that are not of ductal or lobular origin. Case: A 59-year-old female presented with a superficial breast mass. FNAC revealed a hypercellular lesion with marked nuclear atypia that was highly suspicious for carcinoma. However, at partial mastectomy, the histological features of the tumor were consistent with atypical hidradenoma. Negativity for estrogen receptor (ER) and progesterone receptor (PR) confirmed the diagnosis. Eighteen years later, the patient remains free of recurrence or metastasis. Conclusions: This report offers the first description of findings of atypical hidradenoma on FNAC. In the breast, its high cellularity and nuclear atypia can mimic a primary mammary carcinoma on FNAC. Although breast and skin adnexal tumors show a immunohistochemical overlap, negative ER and PR stains in a low-grade tumor can suggest a nonmammary lesion. Skin adnexal neoplasms should be considered in the differential diagnosis of superficial breast tumors.

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Skin and Subcutis

Domański

Stanley

2013

Atlas of Fine Needle Aspiration Cytology

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Cytologic Features of Hidradenoma in Fine Needle Aspiration Biopsies

Cited by 15 publications

References 6 publications

Diagnostic Evaluation of Skin Adnexal Tumors by Fine-Needle Aspiration Cytology

Diagnostic Evaluation of Skin Adnexal Tumors by Fine-Needle Aspiration Cytology

Atypical Hidradenoma Mimicking Primary Mammary Carcinoma on Breast Fine-Needle Aspiration: A Case Report with Long-Term Follow-Up

Skin and Subcutis

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