Cytologic distinctions between clinical groups using curette-probe compared to cytology brush

Assessment of Upper Respiratory Tract and Ocular Irritative Effects of Volatile Chemicals in Humans

“…Bryan and Bryan 296 described the use of a cotton-tipped applicator for directly sampling the superficial epithelial layer. Another method of sampling the superficial epithelium is by scraping either with a cytology brush (Cytobrush Plus; Medscand, MalmÖ, Sweden) 297 or with a plastic curette (Rhino-probe, ASI, Springville, UT). 298 Advantages of these methods include specificity of the sampling site (scraping the surface on the middle third of the inferior turbinate), minimal trauma with no need for anesthesia, ease of repetition, and adequacy of specimen at any age and in all nasal conditions.…”

Nasal Cytobrush Cytology

“…They considered PMN leukocytes in association with epithelial cells rather than as isolated clusters. 5 The presence of…”

“…[1][2][3][4][5] In 1 recent study, careful observation allowed evaluation of the presence of a specific hyperchromatic area in ciliated cells from healthy adults. This area, never seen in other cell types, is the supranuclear stria (SNS).…”

“…with a cytobrush. 1,4,5 This study was done to detect the degree of correlation between cytologic and clinical diagnoses of rhinopathies and to evaluate the SNS, which is observed in the majority of ciliated cells in normal, healthy adults.…”

Nasal allergen challenge studies of allergic rhinitis: a guide for the practicing clinician

“…54e57 Currently, there is no agreement on which method is superior. Lin et al 58 found that scraping samples differentiate those with symptoms of AR from controls better than the cytobrush based on leukocyte and eosinophil quantification. Baccarelli et al 55 used nasal brushing to find associations between nasal cell DNA methylation, markers of lung inflammation, and wheezing in children with asthma.…”