Cytologic and immunocytochemical findings of anaplastic large cell lymphoma

Ng, Wai-Kuen; Ip, Philip; Choy, Carolyn; Collins, Robert J.

doi:10.1002/cncr.10922

Cited by 51 publications

(15 citation statements)

References 82 publications

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“…Neutrophil rich variant have large number of neutrophils admixed with tumor cells. [158] In the present case, the presence of characteristic hallmark cells, plamacytoid cells, cytoplasmic blebbing, doughnut cell, hand mirror cell, sparse lymphoglandular bodies, and apoptotic cells were helpful in the diagnosis on imprint cytology.…”

Section: Discussionmentioning

confidence: 58%

“…However, the presence of characteristic hallmark cells, lymphoglandular bodies, and cytoplasmic budding favors a diagnosis of cutaneous anaplastic large cell lymphoma. [18]…”

Section: Discussionmentioning

confidence: 99%

“…Melanoma cells demonstrate nuclear positivity for S-100 protein and are negative for CD 30 and other lymphoid markers. [89]…”

Section: Discussionmentioning

confidence: 99%

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Imprint cytology facilitating the diagnosis of primary cutaneous anaplastic large cell lymphoma of iliac fossa

Singh

Gupta²,

Tekta³

2012

J Cytol

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Primary cutaneous anaplastic large cell lymphoma (C-ALCL) is a form of cutaneous T-cell lymphoma that is characterized by solitary nodules and plaques. In this report, the authors present an unusual case of a 59-year-old male with a solitary ulcerofungative mass in the left iliac fossa clinically masquerading as sqaumous cell carcinoma. The imprint smears of the lesion had characterstic morphological features which helped in the diagnosis. Subsequently, the imprint cytology correlated well with the histopathology and immunohistochemical studies highlighting its utility as simple, rapid, and easy test.

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Section: Discussionmentioning

confidence: 58%

“…However, the presence of characteristic hallmark cells, lymphoglandular bodies, and cytoplasmic budding favors a diagnosis of cutaneous anaplastic large cell lymphoma. [18]…”

Section: Discussionmentioning

confidence: 99%

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Imprint cytology facilitating the diagnosis of primary cutaneous anaplastic large cell lymphoma of iliac fossa

Singh

Gupta²,

Tekta³

2012

J Cytol

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“…The same low-power features are typical of many cALCLs, in which lymphocytes may aggregate around and within small vessels and endothelial lined spaces. 7 Higher-power findings, for example recognition of the horseshoe-or kidney bean-shaped ''hallmark cells'' of anaplastic large cell lymphoma (ALCL), that were present in our case (Figure 2), in retrospect, could have added more insight into the tumor type prior to immunohistochemical workup. Many of the cytologic features of ALCL, however, such as rounded or wreathlike cells, angulated basophilic nucleoli, abundant amphophilic cytoplasm, and numerous mitoses, 7,8 are also seen in melanoma.…”

Section: Report Of a Casementioning

confidence: 72%

“…Melanoma is, in fact, a well described consideration in the cytomorphologic differential diagnosis of ALCL. 7 It seems clear that, even with the observation of hallmark cells, in this case, concern for melanoma would persist, and immunohistochemistry would have been requested.…”

Section: Report Of a Casementioning

confidence: 98%

Anaplastic Large Cell Lymphoma: A Potential Pitfall in the Differential Diagnosis of Melanoma

Pulitzer

Brady

Blochin

et al. 2013

Archives of Pathology &Amp; Laboratory Medicine

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The diagnosis of metastatic melanoma can be complicated by absent characteristic cytology, melanin, or antigen expression in a suspect tumor, putting the pathologist at risk for incorrectly diagnosing recurrent melanoma while missing a second malignancy. We report a 69-year-old man with a history of acral melanoma, metastatic to inguinal nodes, presenting with an ipsilateral thigh nodule. Histology showed a proliferation of pleomorphic cells in the dermis and subcutis, suspicious for melanoma. S100, Melan-A, and HMB-45 immunohistochemistry were negative. However, microphthalmia-associated transcription factor and CD117 labeled the neoplasm, prompting consideration of a late metastatic melanoma with loss of antigen expression. Subsequent immunolabeling for CD4, CD43, and CD30 and clonal T-cell gene rearrangements enabled the correct diagnosis of cutaneous anaplastic large cell lymphoma. This case illustrates a pitfall in evaluating tumors in patients with known metastatic melanoma, and emphasizes the need for broad-spectrum immunohistochemistry in cases that are not clear-cut.

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Cytomorphologic examination of anaplastic large cell lymphoma by fine-needle aspiration cytology

Rapkiewicz

Wen

Şen

et al. 2007

Cancer

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BACKGROUND. The cytomorphology of anaplastic large cell lymphoma (ALCL) is distinctive yet variable. To the authors' knowledge, to date only small case series have described the cytologic findings noted in patients with ALCL. The current series is the largest case series presented to date to retrospectively review the cytomorpholgic findings noted in patients with ALCL, with specific attention paid to those with anaplastic lymphoma kinase (ALK)-negative ALCL.METHODS. Over a 13-year period, the available Diff-Quik cytology smears and surgical excision specimens taken from patients with ALCL were evaluated. Different clinical and morphologic parameters were evaluated, including ALK status. RESULTS. A total of 37 cases were retrieved and evaluated, 19 of which had both cytology and surgical pathology specimens available for review. ALK-negative ALCL cytology smears were found to have a high number of anaplastic cells compared with ALK-positive cases. The hallmark cells in the ALK-negative cases were not classic. CONCLUSIONS.ALCL can be diagnosed accurately by fine-needle aspiration cytology (FNAC) alone when aided by immunocytochemistry in ALK-positive cases.Ancillary studies should be anticipated such that material for cell block preparation and molecular studies is taken at the time of FNAC. The results of the current study demonstrate the varied FNAC morphology of ALCL. The presence of severe pleomorphism and anaplasia was found to correlate with ALK-negative status.

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Cytologic and immunocytochemical findings of anaplastic large cell lymphoma

Cited by 51 publications

References 82 publications

Imprint cytology facilitating the diagnosis of primary cutaneous anaplastic large cell lymphoma of iliac fossa

Imprint cytology facilitating the diagnosis of primary cutaneous anaplastic large cell lymphoma of iliac fossa

Anaplastic Large Cell Lymphoma: A Potential Pitfall in the Differential Diagnosis of Melanoma

Cytomorphologic examination of anaplastic large cell lymphoma by fine-needle aspiration cytology

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