Cytologic and clinical features of NIFTP: Can we diagnose based on preoperative fine‐needle aspiration

Liang, Yan; Sethi, Shenon; Park, Ji-Weon

doi:10.1002/dc.24309

Cited by 13 publications

(15 citation statements)

References 25 publications

(26 reference statements)

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“…Although this rate is even lower than that of encap-PTC, it is still very high, indicating that most NIFTPs were suspected of being or diagnosed as malignant on cytology. Our results are similar to those of other studies in Japan [4,5], whereas studies from Western countries demonstrated lower rates of Be-V or -VI, i.e., from 23.7% to 45.9% [9]. The reasons for this discrepancy remain unknown.…”

Section: Discussionsupporting

confidence: 88%

See 1 more Smart Citation

Ultrasound findings of noninvasive follicular thyroid neoplasm with papillary-like nuclear features compared with those of follicular variant of papillary carcinoma and encapsulated papillary carcinoma: a single-institution study in Japan

et al. 2020

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Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a new entity adopted by the newest World Health Organization classification. It is differentiated from follicular variant papillary thyroid carcinoma (FVPTC) and regarded as non-malignant disease. Here, we compared the ultrasound findings of NIFTP (n = 40) with those of FVPTC (n = 94) and encapsulated PTC (encap-PTC) (n = 157). The NIFTP group showed benign findings on ultrasound significantly more frequently than the FVPTC group based on the Japan Society of Ultrasonics in Medicine criteria: a regular shape (p < 0.001), well edge definition (p = 0.007), smooth character (p < 0.001), isoechoic and homogeneous internal echoes (p < 0.001), lack of punctate microcalcification (p = 0.027), and a regular marginal hypoechoic zone (p < 0.001). Compared to encap-PTC, NIFTP has a significantly higher incidence of benign findings: isoechoic and homogeneous internal echoes (p < 0.001), lack of punctate microcalcification (p < 0.001), and a regular marginal hypoechoic zone (p = 0.004). Based on the ultrasound classification (USC) system at Kuma Hospital, no cases were classified as malignant (USC ≥3.5), but 55.4% of the FVPTCs and 53.5% of the encap-PTCs were diagnosed as malignancy. However, on cytology, the incidence of NIFTP classified as Bethesda-V or -VI (PTC) was very high at 86.9%. All patients underwent surgical treatment, but none of the NIFTP patients showed postoperative recurrence. Although avoiding surgery might be difficult because of the high incidence of malignant cytology, overtreatment (including extensive surgery) for NIFTP can be avoided by paying close attention to the lack of malignant findings on ultrasound.

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Section: Discussionsupporting

confidence: 88%

“…Several studies have compared NIFTP and FVPTC (non-NIFTP) from various aspects including ultrasonic and pathological findings [4][5][6][7][8][9][10][11][12][13][14][15][16]. On ultrasound, the rate of findings suspected of malignancy in NIFTP was reported to be lower than that in non-NIFTP [10,11,[13][14][15].…”

mentioning

confidence: 99%

Ultrasound findings of noninvasive follicular thyroid neoplasm with papillary-like nuclear features compared with those of follicular variant of papillary carcinoma and encapsulated papillary carcinoma: a single-institution study in Japan

et al. 2020

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“…We hold the opinion that the accurate recognition of NIFTP preoperatively should not only depend on cytopathological results by biopsy, but also referring to ultrasound findings for comprehensive analysis. As for cytopathological results, Bethesda categories 3 [atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS)], 4 [follicular neoplasm/suspicious for follicular neoplasm (FN/SFN)] and 5 (suspicious for malignancy) are the most frequent findings of NIFTP (7)(8)(9)(10). In terms of US presentation, NIFTP always shows less risk features than classical PTC and radiologists may prone to divide NIFTP into benign groups in previous researches (11)(12)(13).…”

Section: Original Articlementioning

confidence: 99%

Three ultrasound phenotypes of non-invasive follicular thyroid neoplasm with papillary-like nuclear features proposed for imaging-pathology analysis: single center experience

Liu¹,

Gao²,

Xia³

et al. 2021

Gland Surg

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Background: The terminology "non-invasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP) was introduced to reduce overtreatment of thyroid carcinomas with indolent behavior.However, limited literature discussed the sonographic features of the entity in depth. The objective of this study is to summarize sonographic subtypes of NIFTP for precise diagnosis.Methods: From January 2017 to June 2020, 13,531 consecutive patients underwent surgery for thyroid nodules were reviewed; 30 patients (0.22%) with 30 NIFTP were eligible for this retrospective observational study. We evaluated ultrasound features of all the lesions and distributed them into 3 major types of ultrasound appearance using pattern recognition. Systemic literature review concerning ultrasonography of NIFTP was also performed.Results: At sonography, all the NIFTP lesions were classified into three types: 19 (63.3%) were categorized into type A-oval and solid nodule without other high-suspicion features, 7 (23.3%) into type B-partially cystic mass without high-suspicion features, 4 (13.3%) into type C-hypoechoic solid nodule with highsuspicion features including irregular margins, microcalcifications, taller-than-wide shape.Conclusions: Three ultrasound patterns were proposed by us for ultrasound-cytopathology correlation analysis.

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“…After NIFTP was introduced as a new entity, many studies on the cytology of NIFTP have been published. Several studies on cytological diagnostic features showed that features related to NIFTP differ mainly from PTC cytopathology and to lesser extent from FVPTC cytopathology [ 67 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 ].…”

Section: Niftp: Cytopathology and Summary Of Cytological Studiesmentioning

confidence: 99%

Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): Tumour Entity with a Short History. A Review on Challenges in Our Microscopes, Molecular and Ultrasonographic Profile

et al. 2022

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Since Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) was introduced as a new thyroid tumour entity, many studies, and meta-analyses on diagnosing NIFTP have been published. NIFTP-revised histopathological criteria emerged in 2018. NIFTP is defined as a histological entity and its diagnosis requires a careful histological examination. Its molecular profile is similar to follicular-like tumours. Ultrasound features are unable to differentiate NIFTP. NIFTP is not a cytological diagnosis, but it influences the risk of malignancy in several categories of The Bethesda System for Reporting Thyroid Cytopathology terminology.

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Cytologic and clinical features of NIFTP: Can we diagnose based on preoperative fine‐needle aspiration

Cited by 13 publications

References 25 publications

Ultrasound findings of noninvasive follicular thyroid neoplasm with papillary-like nuclear features compared with those of follicular variant of papillary carcinoma and encapsulated papillary carcinoma: a single-institution study in Japan

Ultrasound findings of noninvasive follicular thyroid neoplasm with papillary-like nuclear features compared with those of follicular variant of papillary carcinoma and encapsulated papillary carcinoma: a single-institution study in Japan

Three ultrasound phenotypes of non-invasive follicular thyroid neoplasm with papillary-like nuclear features proposed for imaging-pathology analysis: single center experience

Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): Tumour Entity with a Short History. A Review on Challenges in Our Microscopes, Molecular and Ultrasonographic Profile

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