2017
DOI: 10.1099/jmmcr.0.005079
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Cytolethal distending toxin-producing Escherichia coli strains causing severe diarrhoea in young Mexican children

Abstract: Introduction. Cytolethal distending toxins (CDTs), encoded by cdt genes, have DNase activity leading to cellular and nuclear distension, resulting in irreversible cell cycle arrest and apoptosis of target cells. cdt-positive Escherichia coli strains have been isolated from children with diarrhoea. There is, however, scant information on the prevalence and clinical presentation of diarrhoeal disease caused by these strains. Furthermore, toxin production of cdt-positive strains is rarely confirmed. We report fiv… Show more

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Cited by 12 publications
(8 citation statements)
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“…Our results revealed a low incidence of CDT-producing E. coli among human gastroenteritis patients. These findings are similar to larger studies on patients in Korea and Mexico, which yielded CDT E. coli prevalence of 2.7% of 336 patients and 1% of 1060 patients, respectively (4,18). Despite the low proportion of human cases of CDT-producing E. coli among these studies, our results indicate risk of CDT-producing E. coli from retail meats, food processing areas, and livestock.…”
Section: Discussionsupporting
confidence: 90%
“…Our results revealed a low incidence of CDT-producing E. coli among human gastroenteritis patients. These findings are similar to larger studies on patients in Korea and Mexico, which yielded CDT E. coli prevalence of 2.7% of 336 patients and 1% of 1060 patients, respectively (4,18). Despite the low proportion of human cases of CDT-producing E. coli among these studies, our results indicate risk of CDT-producing E. coli from retail meats, food processing areas, and livestock.…”
Section: Discussionsupporting
confidence: 90%
“…and compare it with the cdt of other bacterial species, and also identify the Klebsiella species by biochemical and molecular methods in this way to know what Klebsiella species is positive to pks or cdt. Notably, cdt was the most prevalent cyclomodulin in this study; despite the relationship between cdt and DNA damage, this toxin has also been related to serious cases of diarrhea in Mexican subjects due to E. coli [30,31]. However, we found an association of cdt with non-DECs, but recent work indicates that non-DECs with supplementary virulence genes have high levels of virulence, and are capable of producing diarrhea [32].…”
Section: Discussioncontrasting
confidence: 67%
“…Similarly, none of the samples of patients with IBS and gastroenteritis, and healthy people were positive for cdtB of E. coli and P. alcalifacience. In a study by Meza-Segura et al, out of 1306 young children with acute diarrhea, cdt encoding E. coli strains detected in 1% of the patients [34]. In another study, cdtB gene were found in 1.4% of 366 E. coli strains isolated from stool specimens of patients with acute diarrhea in Calcutta, India [35].…”
Section: Discussionmentioning
confidence: 96%