Cytokinin Activity of 4-Aminopyridopyrimidines toward the Growth of Tobacco Callus

Novel Benzenesulfonate Scaffolds with a High Anticancer Activity and G2/M Cell Cycle Arrest

“…More recently, we investigated the p53 stabilizing agent CP-31398 ( Figure 1 I) as a foundation for styrylquinazoline multi-kinase inhibitors [ 15 ]. During our work on 4-anilinoquinazolines, we found that its synthetic availability through tosylates is more effective than the direct substitution of 4-chloroderivative, which is used more often in the literature [ 16 , 17 , 18 ]. Moreover, the intermediate tosylates that were generated during the synthetic procedure were resistant to hydrolysis in a water environment, which prompted us to test their activity on a panel of cancer cells.…”

Preparation and structure-activity relationships of 4-substituted amino-2-methylpyrido[3,4-d]pyrimidines as cytokinin analogs

“…In our research for developing new cytokinin analogs of non-purine type, we studied syntheses and biological activities of a series of pyridopyrimidines and found that 4-(isopentylamino)-and 4-(benzylamino)pyrido [3,4-d]pyrimidine were weakly active and the replacement of the 2-hydrogen with a methyl group increased the activity in an Amaranthus betacyanin bioassay (Nishikawa et al, 1986a). Additionally, our later studies revealed that the unsubstituted 4-anilino derivative la exhibited a moderate cytokinin activity in a tobacco callus bioassay (Nishikawa et al, 1994). These results suggested that modification at the 2-and 4-positions of the heteroaromatic ring might further enhance the activity.…”