Cytokines, thyroid diseases and thyroid cancer

Lumachi, Franco; Basso, Stefano M.M.; Orlando, Rocco

doi:10.1016/j.cyto.2010.03.005

Cited by 59 publications

(51 citation statements)

References 62 publications

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“…An anaplastic thyroid cancer cellline secretes high levels of IL6 (Chang et al 2003). Despite only a few results linking IL6 directly to thyroid cancer, IL6 may be important for the inflammatory microenvironment in thyroid carcinogenesis, and this microenvironment has already been proven to have an influence on DTC development and progression (Lumachi et al 2010, Cunha et al 2013.…”

Section: Inflammationmentioning

confidence: 99%

Obesity and thyroid cancer

Marcello,

Cunha,

Batista

et al. 2014

Endocrine Related Cancer

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Many studies have provided observational data on the association of obesity and thyroid cancers, but only few of them propose mechanisms that would permit a better understanding of the causal molecular mechanisms of this association. Considering that there is an increasing incidence of both obesity and thyroid cancers, we need to summarize and link recent studies in order to characterize and understand the contribution of obesity-related factors that might affect thyroid cancer development and progression. Adipose tissue is involved in many vital processes, including insulin sensitivity, angiogenesis, regulation of energy balance, activation of the complement system, and responses such as inflammation. Although these processes have their own molecular pathways, they involve the same molecules through which obesity and adipose tissue might exert their roles in carcinogenesis, not only affecting MAPK and PI3K or even insulin pathways, but also recruiting local inflammatory responses that could result in disease formation and progression. This review describes five important issues that might explain the link between excessive weight and thyroid cancer: thyroid hormones, insulin resistance, adipokines, inflammation, and sexual hormones.

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Section: Inflammationmentioning

confidence: 99%

Obesity and thyroid cancer

Marcello,

Cunha,

Batista

et al. 2014

Endocrine Related Cancer

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“…Among them, only LIF-mediated STAT3 signaling has been defined in detail. Recently, dysregulation of LIF and/or the LIF receptor (LIFR) has been reported in several human malignancies, including glioblastoma (21), thyroid cancer (22), rhabdomyosarcoma (23), pancreatic carcinoma (24,25), and breast cancer (26). However, the precise role of LIF in tumorigenesis remains largely unexplored.…”

Section: Introductionmentioning

confidence: 99%

Leukemia inhibitory factor promotes nasopharyngeal carcinoma progression and radioresistance

Liu¹,

et al. 2013

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Radioresistance of EBV-associated nasopharyngeal carcinoma (NPC) is associated with poor prognosis for patients with this form of cancer. Here, we found that NPC patients had increased serum levels of leukemia inhibitory factor (LIF) and that higher LIF levels correlated with local tumor recurrence. Furthermore, in vitro studies with NPC cells and in vivo xenograft mouse studies demonstrated that LIF critically contributes to NPC tumor growth and radioresistance. Using these model systems, we found that LIF treatment activated the mTORC1/p70S6K signaling pathway, enhanced tumor growth, inhibited DNA damage responses, and enhanced radioresistance. Treatment with either soluble LIF receptor (sLIFR), a LIF antagonist, or the mTOR inhibitor rapamycin reversed LIF-mediated effects, resulting in growth arrest and increased sensitivity to γ irradiation. Immunohistochemical (IHC) analyses of human NPC biopsies revealed that LIF and LIFR were overexpressed in tumor cells and that LIF expression correlated with the presence of the activated p-p70S6K. Finally, we found that the EBV-encoded protein latent membrane protein 1 (LMP1) enhances LIF production. Together, our findings indicate that LIF promotes NPC tumorigenesis and suggest that serum LIF levels may predict local recurrence and radiosensitivity in NPC patients.

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“…The technique "grafting printing" [22] uses a directing organic silane monolayer to create (OTS) microchannels, the deposition of an aldehyde-silane between the microchannels, followed by Py grafting. Finally, the Py was chemically polymerized.…”

Section: Microcontact Printing For Ppy Patterning 231 "Grafting Prmentioning

confidence: 99%