Cytokines modulate preimplantation development and pregnancy

Tartakovsky, Boris; Ben-Yair, Edith

doi:10.1016/0012-1606(91)90236-v

Cited by 104 publications

(52 citation statements)

References 26 publications

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“…uterine receptivity are not yet fully understood, considerable evidence indicates that soluble growth factors secreted by the uterine epithelium act directly on the embryo to control this process [4]. In turn, developing embryos have been shown to influence the production of a variety of cytokines that may act in an autocrine fashion or may act to modulate endometrial receptivity [5].…”

Section: Electronic Supplementary Materialsmentioning

confidence: 99%

“…The conditions for culturing pre-implantation embryos in vitro are known to differ from the in vivo environment of the female reproductive tract; in particular, in vitro culture systems are deficient in auto/paracrine factors necessary for optimal embryonic development. To overcome these deficiencies, researchers use chemically defined media containing growth factors or developed culture systems employing co-culturing with growth factor-releasing cells [4,6].…”

Section: Electronic Supplementary Materialsmentioning

confidence: 99%

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Stem cell factor/c-Kit signaling in in vitro cultures supports early mouse embryonic development by accelerating proliferation via a mechanism involving Akt-downstream genes

Lim

Eum

Lee

et al. 2010

J Assist Reprod Genet

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Purpose Stem cell factor (SCF)/c-Kit regulates the proliferation and survival of germ cells or stem cells; however, little is known about the role of SCF/c-Kit in preimplantation embryo development. Methods Using exogenous SCF supplementation and c-Kit siRNA injection, we investigated the role and mechanism of SCF/c-Kit in pre-implantation mouse embryos.Results Addition of soluble SCF to the culture medium improved blastocyst formation. c-Kit gene silencing reduced the rate of blastocyst formation and delayed embryonic development. The number of proliferating cells in c-Kit gene-silenced blastocysts decreased, whereas the number of apoptotic cells in blastocysts obtained from both experimental and the control groups was not affected. RT-PCR, immunostaining and western blotting revealed that proliferation-related Akt downstream targets were substantially affected by c-Kit gene silencing. Conclusion SCF/c-Kit signaling through Akt downstream targets is likely involved in mediating the cleavage and proliferation of blastomeres during mouse pre-implantation embryogenesis.

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Section: Electronic Supplementary Materialsmentioning

confidence: 99%

Section: Electronic Supplementary Materialsmentioning

confidence: 99%

Stem cell factor/c-Kit signaling in in vitro cultures supports early mouse embryonic development by accelerating proliferation via a mechanism involving Akt-downstream genes

Lim

Eum

Lee

et al. 2010

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…Rappolee et al Rizzino and Bowen-Pope, 1985Palmieri et al, 1992aParia and Dey, 1990Slager et al, 1993Tartakovsky and Ben-Yair, 1991Tartakovsky and Ben-Yair, 1991 is known that the membrane proteins of the apical surface of an epithelial layer become less laterally mobile after the formation of tight junctions. The EGF-receptors could contribute to the polarization of the outer blastomeres by their inability to move to all cell surfaces after the formation of tight junctions.…”

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confidence: 99%

Activities of growth factors in preimplantation embryos

Adamson

1993

J of Cellular Biochemistry

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The development of the mammalian preimplantation embryo in vitro occurs more slowly and less successfully compared to development in the uterus. The fact that it can occur at all in a defined protein-free medium suggests that the process is autonomous. Accumulated evidence indicates that a number of peptide growth facto-s contribute in an autocrine fashion to preimplantation development. Other growth factors are maternally derived and act in a paracrine manner on the embryo. Some of these factors such as insulin-related factors stimulate growth preferentially, but others such as epidermal growth factor (EGF) play more important roles in differentiation. Several cytokines appear to be implicated in peri-implantation events and in maternal-fetal interactions. At this stage, the data are mostly descriptive. Are all these different growth factors and receptors necessary for early development? Some implications of apparent redundancy of gene expression are discussed and future studies are predicted.

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“…Исследования на мышиных моде-лях показали, что это один из нескольких цитокинов, влияющих на развитие беременности на ранних сроках [162]. Вызывая экспрессию гена ЦОГ 2 на ранней стадии беременности [163], ФНО α контролирует ЦОГ и таким об-разом влияет на имплантацию бластоцисты, сосудистую проницаемость эндометрия и маточную децидуацию.…”

Section: л е к ц и я научно-практическая ревматология 2011 № 4 47-63unclassified

Drug therapy in patients with rheumatic diseases during pregnancy and lactation

Кошелева¹,

Насонов²

2011

rsp

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Cytokines modulate preimplantation development and pregnancy

Cited by 104 publications

References 26 publications

Stem cell factor/c-Kit signaling in in vitro cultures supports early mouse embryonic development by accelerating proliferation via a mechanism involving Akt-downstream genes

Stem cell factor/c-Kit signaling in in vitro cultures supports early mouse embryonic development by accelerating proliferation via a mechanism involving Akt-downstream genes

Activities of growth factors in preimplantation embryos

Drug therapy in patients with rheumatic diseases during pregnancy and lactation

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