Cytokines in malignant lymphomas: Review and prospective evaluation

Hsu, Su-Ming; Waldron, James; Hsu, Pei-Ling; Hough, Aubrey J.

doi:10.1016/0046-8177(93)90183-h

Cited by 120 publications

(67 citation statements)

References 88 publications

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“…Another hypothesis suggests that ARF results from tubular injury and interstitial fibrosis caused by cytokines such as interleukin-1 and 6 and tumor necrosis factor-a and b released from lymphoma cells. 21 . In the kidneys, clinically significant malignant infiltration is very rare.…”

Section: Discussionmentioning

confidence: 99%

A Case of Acute Renal Failure Caused by Hodgkin's Lymphoma: Concurrent Membranous Glomerulonephritis and Interstitial HL-CD 20 Lymphoid Infiltration

et al. 2011

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Although acute renal failure developing due to malignancies is a frequent condition, malignant renal infiltration is rarely observed among these causes. Among all malignant diseases, the hematolymphoid malignancies are the most prone to renal infiltration. Other types involved in cases with lymphoma are glomerulopathies, including immune-complex glomerular diseases such as minimal change disease, membranous glomerulonephritis, membranoproliferative glomerulonephritis, and focal segmental glomerulosclerosis. We present herein the rare case of a 22-year-old male with both membranous glomerulonephritis and CD20 (+) lymphoid infiltration related to Hodgkin's lymphoma in the renal interstitial tissue, as detected on biopsy. The patient was treated with adriamycin, bleomycin, vinblastine, and dacarbazine protocol after pulse corticosteroid treatment, and a dramatic improvement in renal function was observed after 2 days of treatment. In this article, an exceptional renal involvement of Hodgkin's lymphoma is discussed in light of the related literature.

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Section: Discussionmentioning

confidence: 99%

A Case of Acute Renal Failure Caused by Hodgkin's Lymphoma: Concurrent Membranous Glomerulonephritis and Interstitial HL-CD 20 Lymphoid Infiltration

et al. 2011

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“…The similarity between NHL-TIL and reactive T cells presented in this study suggests that there are common mechanisms responsible for their state of anergy, namely, the inflammatory microenvironment. In reactive and B-NHL lymph nodes, a wide variety of cytokines has been identified (40)(41)(42)(43). IL-10 is produced by T cells, monocytes/macrophages, activated B cells, and malignant B-NHL cells (43,44).…”

Section: Discussionmentioning

confidence: 99%

CD3 hyporesponsiveness and in vitro apoptosis are features of T cells from both malignant and nonmalignant secondary lymphoid organs.

Agrawal¹,

Marquet²,

Delfau‐Larue³

et al. 1998

J. Clin. Invest.

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“…The autopsy showed similar histological features and immunophenotypic profiles in the biopsied lymph node and other tissues. The maintenance of the T-cell-rich pattern in multiple lesions may suggest the stimulatory effects of cytokines secreted by the neoplastic B-cells (7)(8)(9). The lesions were also rich in histiocytes as well as T-cells.…”

Section: Case Reportmentioning

confidence: 94%

An Autopsied Case of T-Cell Rich B-Cell Lymphoma with General Involvement.

et al. 1995

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Autoptic findings of a 77-year-old man with T-cell-rich B-cell lymphoma (TCRBCL)showed predominant infiltration of reactive T-cells with a minority population ofneoplastic B-cells in liver, spleen, pancreas, adrenal gland, stomach, small intestine and heart, as well as, lymph node. DNA studies demonstrated dual rearrangement in the T-cell receptor beta (TCRB), immunoglobulin heavy chain J region (IgJH) and kappa light chain J region (IgjK) genes. (Internal Medicine 34: 243-246, 1995)

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Cytokines in malignant lymphomas: Review and prospective evaluation

Cited by 120 publications

References 88 publications

A Case of Acute Renal Failure Caused by Hodgkin's Lymphoma: Concurrent Membranous Glomerulonephritis and Interstitial HL-CD 20 Lymphoid Infiltration

A Case of Acute Renal Failure Caused by Hodgkin's Lymphoma: Concurrent Membranous Glomerulonephritis and Interstitial HL-CD 20 Lymphoid Infiltration

CD3 hyporesponsiveness and in vitro apoptosis are features of T cells from both malignant and nonmalignant secondary lymphoid organs.

An Autopsied Case of T-Cell Rich B-Cell Lymphoma with General Involvement.

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