Cytokines in adenoviral disease in children: Association of interleukin-6, interleukin-8, and tumor necrosis factor alpha levels with clinical outcome

Mistchenko, Alicia; Díez, Roberto A.; Mariani, Ana Lía; Robaldo, Julio F.; Maffey, Alberto; Bayley-Bustamante, Guillermo; Grinstein, S

doi:10.1016/s0022-3476(05)81360-5

Cited by 124 publications

(89 citation statements)

References 32 publications

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“…22,28 Vast arrays of cytokine and chemokine networks (those implicated include tumor necrosis factor-␣, IL-2, IL-8, RAN-TES [regulated upon activation, normal T-cell expressed and secreted], platelet-derived growth factor, transforming growth factor, and fibroblast growth factor) are activated, perpetuating an inflammatory response. 29,30 In the investigation of pathogenic mechanisms involved in adenovirus infection, Mistchenko et al 31 found that high serum values for IL-6, IL-8, and tumor necrosis factor-␣ are associated with severity of adenovirus infection. We previously showed a significantly elevated percentage of neutrophils in BAL fluid from children with BO following adenovirus or Mycoplasma infection.…”

Section: Discussionmentioning

confidence: 99%

Bronchoalveolar Cellularity and Interleukin-8 Levels in Measles Bronchiolitis Obliterans

Koh

Jung

Koh

et al. 2007

Chest

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Section: Discussionmentioning

confidence: 99%

Bronchoalveolar Cellularity and Interleukin-8 Levels in Measles Bronchiolitis Obliterans

Koh

Jung

Koh

et al. 2007

Chest

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“…Além disso, o aumento de IL-6, IL-8 e TNF-α esteve associado à maior gravidade da infecção por adenovírus 32 .…”

Section: Patogeniaunclassified

Post-infectious bronchiolitis obliterans in children

Champs

Lasmar²,

Camargos³

et al. 2011

J Pediatr (Rio J)

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Objective: To review publications about the main features of postinfectious bronchiolitis obliterans and its history, etiology, epidemiology, risk factors, pathogenesis, histological findings, clinical presentation, complementary tests, diagnostic criteria, differential diagnosis, treatment and prognosis.Sources: Non-systematic review of MEDLINE and LILACS databases and selection of 66 most relevant studies. Summary of the findings:In the post-infectious bronchiolitis obliterans there is an insult to respiratory epithelial cells, and its clinical severity is associated with the degree of lesion and inflammation. Diagnosis is made according to clinical signs and symptoms, by exclusion of main differential diagnoses and with the aid of complementary tests. High resolution CT, particularly images obtained during inspiration and expiration, provide information for the evaluation of the small airways. Pulmonary function tests show fixed airway obstructions and marked decrease of FEF 25-75% . Treatment has not been definitely established, and corticoids have been administered as pulse therapy or by inhalation of high doses of steroids. However, data about its efficacy are scarce in the literature. Long-term prognosis is variable, and there might be either clinical improvement or deterioration into respiratory insufficiency and death.Conclusion: Post-infectious bronchiolitis obliterans is a disease with a high morbidity rate; it should be treated by a multidisciplinary team, and patients should be followed up for a long period of time.J Pediatr (Rio J). 2011;87(3):187-198: Bronchiolitis obliterans, diagnosis, spirometry, CT, child. ResumoObjetivo: Revisar os trabalhos publicados sobre os principais aspectos da bronquiolite obliterante pós-infecciosa, relacionados com sua história, etiologia, epidemiologia, fatores de risco, patogenia, alterações histológicas, manifestações clínicas, exames complementares, critérios diagnósticos, diagnóstico diferencial, tratamento e prognóstico. Fonte dos dados:Realizou-se uma revisão não sistemática nas bases de dados MEDLINE e LILACS, selecionando-se 66 referências mais relevantes. Síntese dos dados:Na bronquiolite obliterante pós-infecciosa ocorre lesão do epitélio respiratório, e a gravidade clínica está relacionada aos diferentes graus de lesão e ao processo inflamatório. O diagnóstico baseia-se no quadro clínico, na exclusão dos principais diagnósticos diferenciais e no auxílio dos exames complementares. A tomografia computadorizada de alta resolução, principalmente com imagens em inspiração e expiração, possibilta a avaliação das pequenas vias aéreas. As provas de função pulmonar caracterizam-se por padrão obstrutivo fixo com redução acentuada do FEF 25-75% . O tratamento não está bem estabelecido, e o uso de corticoides tem sido preconizado em forma de pulsoterapia ou por via inalatória em elevadas doses, no entanto, os dados da literatura a respeito de sua eficácia ainda são escassos. O prognóstico a longo prazo é variável, podendo haver melhora clínica ou evolução par...

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“…However, overproduction of certain proinflammatory mediators such as TNF, IL-6 and IL-8 can be harmful. In infections of lower respiratory tract such a mediator "storm" elicits symptoms analogous to septic shock caused by Gram-negative bacteria [2].…”

Section: Importance Of Ad-induced Adaptive and Innate Responses In VImentioning

confidence: 99%

“…They can be grown to high titers, can be genetically manipulated to accept large pieces of foreign DNA, and infect many different cell types and tissues with high efficiency [1]. However, adenovirus infection and particularly the entry stages elicit a strong innate immune response, which affects the course of adenoviral disease in patients, and also the therapeutic efficiency of recombinant vectors [2,3]. Understanding how these innate responses are generated is of key importance for the treatment of adenovirus disease and vector applications.…”

Section: Introductionmentioning

confidence: 99%

Adenovirus-triggered innate signalling pathways

Fejér¹,

Freudenberg²,

Greber³

et al. 2011

European Journal of Microbiology and Immunology

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Adenoviruses are important infectious agents and also emerging vectors in different biomedical applications. These viruses elicit a strong innate and adaptive immune response, which influences both the course of disease and the success of the applied vectors. Several Toll-like Receptor (TLR)-dependent and -independent mechanisms contribute to these responses. Understanding of the involved viral and cellular factors is crucial for the treatment of various adenovirus diseases and the optimal design of adenovirus vector applications. Here we summarize our current understanding of the complex nature of adenovirus-induced innate immune mechanisms.

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Cytokines in adenoviral disease in children: Association of interleukin-6, interleukin-8, and tumor necrosis factor alpha levels with clinical outcome

Cited by 124 publications

References 32 publications

Bronchoalveolar Cellularity and Interleukin-8 Levels in Measles Bronchiolitis Obliterans

Bronchoalveolar Cellularity and Interleukin-8 Levels in Measles Bronchiolitis Obliterans

Post-infectious bronchiolitis obliterans in children

Adenovirus-triggered innate signalling pathways

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