Cytokines and organ transplantation. A review

Pirenne, Jacques; Pirenne-Noizat, F; Groote, D. De; Vrindts, Y; López, Miguel Fraile; Gathy, R.; Jacquet, Nicolas; Meurisse, Michel; Honoré, Pierre; Franchimont, P

doi:10.1016/0969-8051(94)90076-0

Cited by 16 publications

(10 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IFN-γ has been shown by others to be dichotomous in its roles in transplantation, being both a protective and pro-rejection factor (33, 34). IFN-γ production by splenic effector and graft infiltrating T cells is commonly used as a marker of effector priming to alloantigen, and we show that CXCR3 antagonism in cardiac allograft recipients depresses the frequency of donor-specific IFN-γ-producing CD8 T cells in the recipient spleen.…”

Section: Discussionmentioning

confidence: 99%

CXCR3 Antagonism Impairs the Development of Donor-Reactive, IFN-γ-Producing Effectors and Prolongs Allograft Survival

et al. 2009

View full text Add to dashboard Cite

Background Current immunosuppression regimens are highly toxic to transplant recipients and, in many cases, acute rejection episodes occur due to escape of donor-reactive lymphocytes from the immunosuppression. T cells are the mediators of acute, cell-mediated graft damage and are hypothesized to use the CXCR3 chemokine axis for migration into the allograft. In the current study, we investigated the effect of CXCR3 blockade using a non-peptide, small molecule inhibitor, AMG1237845, in murine cardiac allograft survival. Methods C57BL/6 (H-2b) mice received vascularized cardiac allografts from A/J (H-2a) donors and were treated with the CXCR3 antagonist. Histological and flow cytometric analyses were used to measure infiltration of leukocytes, and qRT-PCR and IFN-γ ELISPOT assays were used to measure donor-specific reactivity. Results CXCR3 antagonism modestly prolonged allograft survival compared to vehicle treatment, but at time-matched intervals post-transplant, neutrophil, CD8+, and CD4+ T cell infiltration was indistinguishable. While proliferation of donor-reactive naïve T cells was unaffected by CXCR3 antagonism, the frequency of IFN-γ-producing cells in the recipient spleen was significantly reduced by AMG1237845 treatment. CXCR3 blockade for 30 days synergized with short-term, low-dose anti-CD154 mAb to prolong survival past 50 days in 75% of grafts and past 80 days in 25% of the cases. Conclusions These results indicate that in synergy with co-stimulation blockade, CXCR3 is a viable therapeutic target to prevent acute graft rejection.

show abstract

Section: Discussionmentioning

confidence: 99%

CXCR3 Antagonism Impairs the Development of Donor-Reactive, IFN-γ-Producing Effectors and Prolongs Allograft Survival

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Although it has been reported that some cytokines has regulatory effects on cell adhesion molecule expression [14] and our previous works also has reported cigarette smoking could induce Ana-1 to release TNF-a and human umbilical vein endothelial cells (HUVECs) could increase expression of ICAM-1 after treated with the supernatant of Ana-1 challenged by cigarette smoking [15]. Since macrophages could secrete many kinds of cytokines including TNF-a, we would like to know which cytokines play more important role in this process.…”

Section: Introductionmentioning

confidence: 99%

Nicotine could augment adhesion molecule expression in human endothelial cells through macrophages secreting TNF-α, IL-1β

Wang

et al. 2004

International Immunopharmacology

View full text Add to dashboard Cite

“…The detection of cytokines and soluble immunological receptors in sera bears diagnostic relevance in many diseases. In specialized diagnostics, the evaluation of cytokine profiles can improve medical care and facilitate therapeutic decisions not only in diseases such as septicemia, tumors, and systemic inflammation (9) but also in postoperative monitoring of organ transplantation (28). The diagnostic application of these parameters, on the other hand, depends critically on the knowledge of normal serum values.…”

mentioning

confidence: 99%

Age-Dependent Levels of Select Immunological Mediators in Sera of Healthy Children

Sack

Burkhardt²,

Borte

et al. 1998

Clin Diagn Lab Immunol

View full text Add to dashboard Cite

Serum cytokine levels were measured in 275 healthy children of different ages (3 to 17 years). Interleukin-1 receptor antagonist (IL-1RA), soluble IL-2R (sIL-2R) (sCD25), IL-6, IL-8, tumor necrosis factor alpha (TNF-α), soluble TNF receptor type II (sTNF-RII) (sCD120b), gamma interferon (IFN-γ), soluble intercellular adhesion molecule 1 (sICAM-1) (sCD54), soluble E selectin (sE-selectin) (ELAM-1; sCD62E), sCD14, and neopterin were measured with commercial test kits. The mean levels of IL-1RA, sIL-2R, TNF-α, sICAM-1, sE-selectin, and sCD14 were higher than in healthy adults. In contrast, IFN-γ and IL-8 were hardly detectable in children and thereby significantly lower than in adults. In the case of TNF-α, sICAM-1, sE selectin, and sCD14, there was a high interindividual variability, apparently unrelated to disease. The profiles of some cytokines, i.e., IL-1RA, IL-6, and TNF-α, showed age-related increases that overlapped with known patterns of physical growth. Of note, sIL-2R and sE-selectin instead declined with time. Because of the remarkable age-dependent variability in healthy pediatric subjects, disease-related changes, as well as therapy-dependent alterations, should be considered with caution.

show abstract

Cytokines and organ transplantation. A review

Cited by 16 publications

References 18 publications

CXCR3 Antagonism Impairs the Development of Donor-Reactive, IFN-γ-Producing Effectors and Prolongs Allograft Survival

CXCR3 Antagonism Impairs the Development of Donor-Reactive, IFN-γ-Producing Effectors and Prolongs Allograft Survival

Nicotine could augment adhesion molecule expression in human endothelial cells through macrophages secreting TNF-α, IL-1β

Age-Dependent Levels of Select Immunological Mediators in Sera of Healthy Children

Contact Info

Product

Resources

About