Cytokines and nitric oxide in case of bronchial asthma

The research objective is to determine the state of endothelium-dependent and endothelium-independent vasodilatation in patients with coronary heart disease (CHD) associated with chronic obstructive pulmonary disease (COPD).Material and methods. In the cross-sectional study included 122 patients with CHD associated with COPD: 68 people of them are patients with stable angina without acute coronary events in history and 54 patients with acute ST segment elevation myocardial infarction (STEMI). Comparison group comprised 53 patients with stable angina and 51 patients after STEMI without concomitant COPD. Patients were included if they met the following inclusion criteria: male, age <60 years, verified forms of CHD (stable angina, STEMI), documented with COPD without exacerbation and forced expiratory volume in 1 second > 30% in the groups with CHD and COPD. Arterial endothelial function was tested with high-resolution ultrasonography: brachial artery diameter was measured at rest, after flow increase (which causes endothelium-dependent dilatation), and after administration of sublingual nitroglycerin (an endothelium-independent dilator).Results. We found that endothelial dysfunction in patients with acute and chronic forms of CHD in combination with COPD are more pronounced than in isolated CHD.Conclusion. Expressed depression functional vascular reserve in patients with CHD associated with COPD, should be taken into account when conducting individualized therapy of these patients.

show abstract

Endothelial Dysfunction in Stable Angina and Myocardial Infarction Combined With Chronic Obstructive Pulmonary Disease

Попова

Терентьева

Долгополова

et al. 2015

Bûll. sib. med.

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Cytokines and nitric oxide in case of bronchial asthma

Abstract: Complex interactions between nitric oxide and cytokines of atopic inflammation are presented. The effects of interleukin-4 on nitric oxide synthesis, immunoregulatory properties of nitric oxide and its influence on Th1/Th2 balance are described.

Cited by 1 publication

References 35 publications

Endothelial Dysfunction in Stable Angina and Myocardial Infarction Combined With Chronic Obstructive Pulmonary Disease

Endothelial Dysfunction in Stable Angina and Myocardial Infarction Combined With Chronic Obstructive Pulmonary Disease

Contact Info

Product

Resources

About