Cytokines and Mucosal Immune Responses to Helicobacter pylori

Crabtree, Jean E.; Shallcross, T M; Heatley, R. V.; Wyatt, J I

doi:10.1007/978-3-642-77486-7_32

Cited by 11 publications

(13 citation statements)

References 45 publications

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“…Decreased local immune responses may also be relevant, because in a previous study, we found a total absence of B cells in the gastric mucosa of patients with CVID and gastritis 30. It has also been suggested that IgA plays a major defensive role in the gastric juice, by inhibiting H pylori motility and adhesion and neutralising the toxins produced 31. Although a normal antibody response does not appear to be able to eradicate H pylori ,6 it could be argued that the absence of IgA in patients with CVID does contribute to the pathogenicity of H pylori .…”

Section: Discussionmentioning

confidence: 99%

Gastric pathology in patients with common variable immunodeficiency

Zullo¹,

Romiti

Rinaldi

et al. 1999

Gut

111

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Background/Aims-Common variable immunodeficiency (CVID) is an immunological disorder characterised by defective antibody production. Patients with CVID have a high risk of gastric cancer. It has been suggested that gastric cancer results from an interaction between environmental factors and a genetic predisposition. The role of Helicobacter pylori as an environmental factor in gastric carcinogenesis is of current interest. Moreover, p53 gene mutations have been reported in gastric cancer. This study focuses on the gastric pathology of patients with CVID and correlation with H pylori infection. Methods-Thirty four consecutive dyspeptic patients with CVID (mean age 49.6 years, range 14-72; 17 men) were included in the study. An upper gastrointestinal endoscopy was performed and biopsy specimens were taken from the antrum, incisura angularis, and gastric body. Biopsies were used for histological assessment, to identify the presence of H pylori, and to evaluate p53 overexpression. Results-H pylori infection was detected in 14/34 (41%) patients. Chronic active gastritis involving both antrum and body was observed more frequently in H pylori positive (79%) than H pylori negative (20%) patients (p = 0.001). Similarly, a histological feature of multifocal atrophic gastritis was found more frequently in infected (50%) than uninfected patients (10%) (p = 0.012). In addition, one case of gastric adenocarcinoma and another of notable dysplasia were observed in the H pylori positive group. Overexpression of p53 was found in six (18%) patients, including one with normal gastric mucosa. Conclusions-It can be hypothesised that both H pylori and p53 alterations play a role in the gastric carcinogenesis of patients with CVID. (Gut 1999;45:77-81)

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Section: Discussionmentioning

confidence: 99%

Gastric pathology in patients with common variable immunodeficiency

Zullo¹,

Romiti

Rinaldi

et al. 1999

Gut

111

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“…The vast majority of individuals who are colonized with Helicobacter pylori remain infected despite the development of vigorous immune responses to the bacterium (5). For this reason, it is generally assumed that host immune responses are ineffective in clearing the infection.…”

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confidence: 99%

Effect of Low-Dose Antigen Exposure on Development of Immunity to Helicobacter pylori Infection in Mice

Radcliff

Ferrero

2001

Infect Immun

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“…Many ELISA kits for detection of H. pylori antibodies are available and have reportedly provided highly reliable results in Western countries (Evans et al, 1989;Crabtree et al, 1991;Jensen et al, 1993;Schembri et al, 1993;Marchildon et al, 1996;Wilcox et al, 1996;Meijer et al, 1997;Leung et al, 1999;Raymond et al, 1999). However, diagnostic accuracy of kits made in Western countries has been reported to be lower in Chinese patients (Leung et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of serological kits for Helicobacter pylori infection with the same assay system but different antigens in a Japanese patient population

Obata

Kikuchi

Miwa

et al. 2003

Journal of Medical Microbiology

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Helicobacter pylori infection is thought to be a causal risk factor for gastric carcinoma. Recently, diagnostic accuracy of serological kits for H. pylori infection that were made in Western countries has been reported to be lower when used among Oriental populations. Diagnostic accuracy of two serological kits [HM-CAP and HM-CAP with antigens extracted from clinically isolated Japanese H. pylori strains (J-HM-CAP)] was investigated in 440 samples from a Japanese patient population by using the 13 C-urea breath test as gold standard. According to the original optimal cut-off value, HM-CAP provided 87·5 % sensitivity and 84·8 % specificity with 86·8 % accuracy and J-HM-CAP provided 95·5 % sensitivity and 81·9 % specificity with 92·3 % accuracy. This study suggests that antigens from HM-CAP are satisfactory for examining a Japanese patient population, but that using local antigens improves accuracy.

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Cytokines and Mucosal Immune Responses to Helicobacter pylori

Cited by 11 publications

References 45 publications

Gastric pathology in patients with common variable immunodeficiency

Gastric pathology in patients with common variable immunodeficiency

Effect of Low-Dose Antigen Exposure on Development of Immunity to Helicobacter pylori Infection in Mice

Diagnostic accuracy of serological kits for Helicobacter pylori infection with the same assay system but different antigens in a Japanese patient population

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