Cytokines and Lymphoma

Abstract

Currently lymphoma is mainly treated with combination chemotherapy, hematopoietic stem cell transplantation, immunotherapy, and new targeted therapy, but treatment-related drug resistance, recurrence, extranodal and central infiltration, and leukemic transformation are still clinical problems that need to be solved urgently. Studies have shown that cytokines are expressed to varying degrees in lymphoma patients, which are significantly related to the progression of lymphoma, poor prognosis, chemotherapy response, and drug resistance. It has been confirmed that interleukin 6 (IL-6) and IL-10 are highly expressed in all types of lymphoma, and IL-10 is highly expressed in cerebrospinal fluid of central nervous system lymphoma, and both of them indicate poor prognosis. This review discusses the role of cytokines in the development and potential treatment of lymphoma.