Cytokines and Inflammatory Recruitment in NASH: Experimental and Human Studies

Li, Zhiping; Diehl, Anna Mae

doi:10.1002/9780470987438.ch10

Cited by 3 publications

(6 citation statements)

References 40 publications

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“…In conclusion, our study showed that the degree of liver fibrosis was significantly correlated with age, TNF-α and type IV collagen concentrations. The level of HA and type IV collagen could differentiate between mild fibrosis (stages 1-2) and advanced fibrosis (stages [3][4]. Further prospective studies with larger samples are needed.…”

Section: Resultsmentioning

confidence: 99%

“…Immunological mechanisms have an important role in the pathogenesis of NASH. Studies both in human and animal models have shown the role of pro‐inflammatory cytokines in causing hepatic injury 3 . The pathogenesis involved increased tumor necrosis factor‐α (TNF‐α) which was found in obese patients and contributed to the development of insulin resistance.…”

Section: Introductionmentioning

confidence: 99%

“…Studies both in human and animal models have shown the role of pro-inflammatory cytokines in causing hepatic injury. 3 The pathogenesis involved increased tumor necrosis factor-α (TNF-α) which was found in obese patients and contributed to the development of insulin resistance. The production of TNF-α is believed to be the first event in liver injury, triggering the production of other cytokines that recruit inflammatory cells, destroy hepatocytes and initiate a healing response, including fibrogenesis.…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic value of a group of biochemical markers of liver fibrosis in patients with non‐alcoholic steatohepatitis

Lesmana¹,

Hasan²,

Budihusodo³

et al. 2009

J of Digest Diseases

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OBJECTIVE: The objectives of this study were to investigate the use of non‐invasive biochemical markers to evaluate the severity of liver fibrosis in patients with non‐alcoholic steatohepatitis (NASH). METHODS: This was a cross‐sectional study of patients with histopathologically confirmed NASH between January 2005 and December 2006. The patients’ characteristics were recorded and the body mass index was calculated for each patient. All patients underwent ultrasound‐guided liver biopsy and a fibrosis assessment was performed using the Brunt criteria. The non‐invasive laboratory markers measured were insulin resistance, tumor necrosis factor (TNF‐α), type IV collagen and hyaluronic acid (HA). RESULTS: Thirty patients were recruited, of whom 18 (60%) were men. Their mean age was 45 ± 13.9 (18–71) years. About 83% of patients had fibrosis stage 1–2. In bivariate analysis, age, TNF‐α and type IV collagen concentrations showed a weak but significant correlation with the fibrosis stage. When the patients were grouped into mild fibrosis (stages 1–2) and advanced fibrosis (stages 3–4), the mean concentrations of HA and type IV collagen were significantly higher in those with advanced fibrosis than those with mild fibrosis (180.8 ± 49.63 vs 543.6 ± 360.45 ng/mL; for HA; P = 0.026 and 125.3 ± 32.11 vs 288.0 ± 171.22 ng/mL for type IV collagen; P = 0.010). CONCLUSION: Our study showed that the degree of liver fibrosis was significantly correlated with age, TNF‐α and type IV collagen concentrations. The level of HA and type IV collagen could differentiate between mild (F1–2) and advanced fibrosis (F3–4).

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Diagnostic value of a group of biochemical markers of liver fibrosis in patients with non‐alcoholic steatohepatitis

Lesmana¹,

Hasan²,

Budihusodo³

et al. 2009

J of Digest Diseases

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show abstract

“…Included in the spectrum of NAFLD are the relatively benign ‘simple steatosis’ and the more progressive ‘nonalcoholic steatohepatitis’ (NASH), the latter which may lead to cirrhosis in 15–25% of patients 3–6 . The pathogenesis of NASH is thought to be a multistep process in which steatosis (due to insulin resistance in most cases) is the initial step, and oxidative stress and cytokine mediated inflammation/apoptosis are important subsequent steps 7,8 . Among the various cytokines implicated in the pathogenesis of NASH, tumor necrosis factor alpha (TNFα) has received the greatest attention, and there is growing clinical evidence to support a pathophysiological role for this cytokine in NASH.…”

Section: Introductionmentioning

confidence: 99%

“…In contrast to genetically obese rodents, MCD rodents are neither leptin/leptin receptor deficient or obese, and they develop steatohepatitis rather than simple steatosis 30–32 . Leptin deficiency and obesity may influence the cytokine environment 7 and thus, potentially, hepatic sensitivity to LPS. It is therefore of interest to establish the effects of LPS in the MCD model of steatohepatitis in which leptin deficiency and obesity are absent.…”

Section: Introductionmentioning

confidence: 99%