Cytokines and Evolution: In Vitro Effects of IL-1α, IL-1β, TNF-α and TNF-β on an Ancestral Type of Stress Response

Ottaviani, Enzo; Caselgrandi, Eva; Franceschi, Claudio

doi:10.1006/bbrc.1995.1185

Cited by 51 publications

(34 citation statements)

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“…Therefore, the behaviour of PDGF-AB and TGF-ßl with regard to CRH is similar to that observed with cytokines [3,4]. Indeed, using the same experimental approach, IL-2 was able to elicit the release of biogenic amines from hemocytes, but this response was significantly reduced when the hemolymph was incubated with CRH after pre-incubation with IL-2.…”

Section: Discussionsupporting

confidence: 68%

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Effect of PDGF and TGF‐β on the release of biogenic amines from invertebrate immunocytes and their possible role in the stress response

1997

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PDGF-AB and TGF-ßl intervene in molluscan stress response, the former inhibiting and the latter inducing the release of norepinephrine and epinephrine from hemocytes. These amines are down-regulated even when TGF-ßl is added to hemolymph pre-incubated with PDGF-AB. The opposite behaviour is observed if the growth factors are reversed. The dopamine response is not affected in either case, even after the addition of CRH or ACTH. After pre-incubation with PDGF-AB or TGFßl in the presence of CRH or ACTH, norepinephrine and epinephrine release falls. These findings suggest that when the interaction is between growth factors, the order of combination is crucial, while in cases where the interaction is between growth factors and other peptides, such as CRH and ACTH, the order is of no importance.© 1997 Federation of European Biochemical Societies.

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Section: Discussionsupporting

confidence: 68%

“…Furthermore, studies on the relationship between cytokines and biogenic amine release have shown that, as in vertebrates, cytokines are also involved in invertebrate stress response [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Effect of PDGF and TGF‐β on the release of biogenic amines from invertebrate immunocytes and their possible role in the stress response

1997

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“…A similar competition has been proposed for other cytokines, i.e. IL-la, IL-lß, TNF-a and TNF-ß, which are also able to influence stress response (Ottaviani et al, 1995a). From these findings, another important evolutive aspect of cytokine physiology emerges, i. e. the high promiscuity of cytokine receptors.…”

Section: Role Of Cytokines and Growth Factorssupporting

confidence: 66%

“…From these findings, another important evolutive aspect of cytokine physiology emerges, i. e. the high promiscuity of cytokine receptors. Indeed, it has been demonstrated that mammalian cytokine receptors are multi-subunit in structure, so explaining their functional redundancy if a signal transducing receptor component is shared by different receptor subunits (Miyajima et al, 1992;Taga & Kishimoto, 1992;Kondo et al, 1993;Noguchi et al, 1993;Russell et al, 1993)-These discoveries on the promiscuity among receptors for cytokines and neuropeptides, such as CRH (Ottaviani et al, 1994b(Ottaviani et al, , 1995a, could represent one of the evolutionary bases to explain the cross-talk between the immune and neuroendocrine systems at molecular level.…”

Section: Role Of Cytokines and Growth Factorsmentioning

confidence: 99%

Presence and role of cytokines and growth factors in invertebrates

Ottaviani

Franchini

Kletsas

et al. 1996

Italian Journal of Zoology

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Available data from our and other laboratories on the presence and biological functions of cytokine-and growth factor-like molecules in invertebrates are reviewed. It appears that IL-1α-, IL-1ß-, IL-2-, IL-6-, TNF-α-like molecules and haemokinin are present in several cell types from molluscs, insects, annelids, echinodems and tunicates. In most cases, these molecules are present in cells with phagocytic activity and they modulate cell motility. PDGF-, TGF-ß-, EGF-and NGF-like molecules, growth promoting factors and the hemolymph trophic factor are present in several cell types from molluscs, insects and annelids. These molecules are probably involved in the control of cell proliferation. Both cytokines and growth factors appear to be highly ancestral and biologically very important molecules, as evident from their continuous presence from invertebrates to vertebrates. It also appears that cytokines are functionally conserved molecules, which during evolution have also maintained their pleiotropicity, redundancy in mode of action and the promiscuity of their receptors.

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“…Until now, with respect to cytokines, the examination of immune-neuroendocrine interactions in fish has been limited to the use of mammalian recombinant cytokines and cytokine antibodies (Balm et al 1995, Ottaviani et al 1995, Balm 1997). However, due to differences in sequence homologies, mammalian cytokine reagents may not necessarily behave in the same way (if at all) as the corresponding fish molecules, a premise exemplified by the absence of a cortisol response to murine IL-1 in tilapia (Balm et al 1995, Balm 1997.…”

Section: Discussionmentioning

confidence: 99%

Recombinant interleukin-1 beta activates the hypothalamic-pituitary-interrenal axis in rainbow trout, Oncorhynchus mykiss

Holland

Pottinger²,

Secombes

2002

Journal of Endocrinology

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The present study provides the first direct evidence that implicates fish cytokines as the effector molecules by which the immune system signals the neuroendocrine system and activates the hypothalamic-pituitary-interrenal stress axis. I.p. injections of trout recombinant interleukin-1 (rIL-1 ) or E. coli lipopolysaccharide (LPS), at concentrations known to induce immune/inflammatory responses in vivo (0·1-0·6 nmol/kg and 1·3 mg/kg respectively), significantly elevated plasma cortisol levels in a dose-and/or time-dependent manner. However, in contrast to general stress responses in fish, under the conditions employed in this study, no specific treatment effects on plasma glucose levels could be demonstrated. The trout IL-1 peptides (P1 and P3), which are homologous to receptor-binding sequences of human IL-1 , failed to influence the prevailing cortisol concentration even though an equivalent dose has been found to have immunostimulatory properties in vivo. Blockade of endogenous ACTH release by administration of the synthetic glucocorticoid dexamethasone prevented the rIL-1 /LPS-mediated elevation of plasma cortisol, suggesting that IL-1 and LPS modulate cortisol secretion via effects at the level of the hypothalamic-pituitary axis. These data indicate that, with respect to IL-1 , cytokine signalling between the immune and neuroendocrine systems in mammals appears to be conserved in lower vertebrates.

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Cytokines and Evolution: In Vitro Effects of IL-1α, IL-1β, TNF-α and TNF-β on an Ancestral Type of Stress Response

Cited by 51 publications

References 0 publications

Effect of PDGF and TGF‐β on the release of biogenic amines from invertebrate immunocytes and their possible role in the stress response

Effect of PDGF and TGF‐β on the release of biogenic amines from invertebrate immunocytes and their possible role in the stress response

Presence and role of cytokines and growth factors in invertebrates

Recombinant interleukin-1 beta activates the hypothalamic-pituitary-interrenal axis in rainbow trout, Oncorhynchus mykiss

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