Cytokines and chemokines systemic levels are related to dialysis adequacy and creatinine clearance in patients with end-stage renal disease undergoing hemodialysis

Silva, Robson E.; Santos, Eliziária Cardoso dos; Justino, Patrícia B I; Santos, Margarida P; Galdino, Giovane; Gonçalves, Reggiani Vilela; Novaes, Rômulo Dias

doi:10.1016/j.intimp.2021.108154

Cited by 7 publications

(4 citation statements)

References 61 publications

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“…With similar preoperative coagulation and complement activation markers in PTA and SPK recipients, a pre-existing increased thrombogenicity in PTA compared to SPK recipients appears unlikely, even if the platelet dysfunction associated with uremia could be protective for SPK recipients ( 32 ). The higher absolute cytokine concentrations found in SPK compared to PTA recipients can be caused by chronic inflammation precipitated by chronic kidney disease and hemodialysis, together with a decreased renal clearance ( 33 , 34 ).…”

Section: Discussionmentioning

confidence: 99%

Thromboinflammatory response is increased in pancreas transplant alone versus simultaneous pancreas-kidney transplantation and early pancreas graft thrombosis is associated with complement activation

et al. 2023

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BackgroundPancreas transplant alone (PTA) recipients are more affected by pancreas graft thrombosis, and graft loss compared to simultaneous pancreas-kidney (SPK) recipients. The pathophysiology is unknown, but an increased immune response has been suggested in the PTA recipients. In this observational study, we compared perioperative thromboinflammation between PTA (n=32) and SPK (n=35) recipients, and between PTA recipients with (n=14) versus without (n=18) early graft thrombosis.MethodsWe measured C-reactive protein (CRP), plasma markers of activated coagulation and complement, and cytokines preoperatively and daily during the first postoperative week.ResultsPreoperatively, coagulation and complement activation markers were comparable between PTA and SPK recipients, while cytokine concentrations were higher in SPK recipients (TNF, IL-8, IP-10, MCP-1, MIP-1α; all p<0.05). On the first postoperative day, PTA recipients had higher coagulation activation, measured as thrombin-antithrombin complex (TAT), than SPK recipients (p=0.008). In the first postoperative week, PTA recipients showed higher relative cytokine release (IL-6, IL-8, G-CSF, IP-10, MCP-1, and MIP-1α; all p<0.05) while SPK recipients showed higher absolute cytokine concentrations (TNF, IL-1ra, IL-8, MIP-1α, and IL-4; all p<0.05). PTA and SPK recipients showed similar terminal complement complex (TCC, sC5b-9) activation. On the first postoperative day, TCC (OR 1.2 [95% CI 1.0-1.5] for 0.1 CAU/ml increase, p=0.02) and CRP (OR 1.2 [95% CI 1.0-1.3] for 10 mg/L increase, p=0.04) were associated with an increased risk of early graft thrombosis. TCC was specific for graft thrombosis, while CRP increased with several complications. PTA recipients with compared to those without graft thrombosis had higher TCC pre- (p=0.04) and postoperatively (p=0.03).ConclusionThe relative increase in postoperative thromboinflammatory response was more pronounced in PTA recipients. Complement activation was associated with an increased risk of graft thrombosis. This study indicates that innate immune activation rather than elevated levels may affect early postoperative pancreas graft thrombosis.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/NCT01957696, identifier NCT01957696

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Section: Discussionmentioning

confidence: 99%

Thromboinflammatory response is increased in pancreas transplant alone versus simultaneous pancreas-kidney transplantation and early pancreas graft thrombosis is associated with complement activation

et al. 2023

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“…While another study found that there was no significant correlation between CCL2 levels with total cholesterol, HDL-c, LDL-c, VLDL-c, non-HDL fraction, or triglycerides [29]. On the other hand, a significant positive correlation was found between CCL2 and creatinine [37].…”

Section: Discussionmentioning

confidence: 93%

Study the Association between Dyslipidemia and CCL2 in Patients Undergoing Hemodialysis

M.Awadallah

Ahmad

.A.

et al. 2023

Benha Journal of Applied Sciences

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Background: Chronic kidney disease (CKD) is becoming a major public health problem worldwide, with a high prevalence in developing countries. C-C Motif Chemokine Ligand 2 (CCL2), also known as monocyte chemotactic protein-1 (MCP-1) can be produced by a variety of cells, reaching increased levels in dyslipidemic patients.Aim: The present study was to identify the relation between dyslipidemia and CCL2 in patients undergoing hemodialysis.Subjects and methods: This case-control study was conducted on 80 subjects: 60 hemodialyzed patients who were recruited from the Nephrology Department and Renal Dialysis Unit at Benha University Hospital and 20 apparently healthy controls. All participants were subjected to full history taking, complete clinical examination, and laboratory investigations including lipid profile and CCL2 were measured. The association between CCL2 levels and dyslipidemia was investigated using linear regression, adjusted for classic and non-classical CVD risk factors.Results: A significant association was observed between CCL2 levels and dyslipidemia (P˂0.001), even after adjustment for possible confounding variables, such as age and gender (P=0.001), as well as, predictor after adjustment with body mass index, diabetes mellitus, HD time, and urea (P˂0.001). Conclusion: Our study suggests that CCL2 levels may contribute to the development of cardiovascular disease in HD patients by promoting dyslipidemia. Through a better understanding of this pathogenesis, new therapeutic targets could be discovered to reduce cardiovascular complications for these patients.

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“…Second, reduced spKt/V has been shown to be associated with toxins accumulation and potentially indicates the systemic inflammatory stress determined by increased CRP levels, up-regulation of proinflammatory cytokines and chemokines, and downregulation of anti-inflammatory cytokines. 14,20,27 Chronic inflammation is a well-documented characteristic in patients on HD, often stemming from various factors like the accumulation of uremic toxins, oxidative stress, and constant exposure to dialysis membranes, among others. 33 Intriguingly, in the context of COVID-19, chronic inflammation at baseline may have a somewhat paradoxical effect, potentially offering a degree of protection against severe outcomes in patients undergoing HD.…”

Section: Discussionmentioning

confidence: 99%

“…11 Falling below the recommended spKt/V of 1.2 has been associated with persistent chronic inflammation and increased oxidative stress, factors that may potentially amplify the inflammatory response triggered by a COVID-19 infection. 14,15 This, in turn, could contribute to the emergence of long-term COVID symptoms in patients undergoing HD.…”

Section: Introductionmentioning

confidence: 99%

Hemodialysis dose and long-term COVID-19 outcomes – a retrospective cohort study

Stepanova,

Rysyev,

Snisar

2024

Eur J Clin Exp Med

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Introduction and aim. Long-term outcomes of COVID-19 pose a global challenge, particularly impacting individuals with un derlying health conditions, including those who have undergone hemodialysis (HD). The study aimed to investigate the rela tionship between preexisting dialysis dose, measured by single pool Kt/V (spKt/V), and long-term outcomes of COVID-19 in patients undergoing HD. Material and methods. Demographic, clinical, and laboratory parameters following COVID-19 recovery, and long-term out comes, including the presence of COVID-19 sequelae, hospitalization, and all-cause mortality during a year after COVID-19 were retrospectively analyzed. Results. Out of the 195 patients included, there were 108 males (55.4%) and 87 females (44.6%), with a median age of 56 (44-63) years and a dialysis duration of 49 (31.3–85.2) months. Patients with spKt/V<1.4 had a significantly increased risk of long-term COVID-19 sequelae (HR 9.1, 95% CI: 3.4; 24.6), hospitalization (HR 7.6, 95% CI: 3.9; 14.6), and all-cause mortality (HR 8.5, 95% CI: 2.9; 25.8) within one year after COVID-19 recovery compared with those with spKt/V≥1.4. spKt/V cutoff point of ≤1.3 emerged as a significant risk factor for one-year hospitalization and mortality within our cohort. Conclusion. Suboptimal dialysis dose, as indicated by spKt/V < 1.4, is associated with adverse long-term COVID-19 outcomes in patients undergoing HD. Optimizing dialysis adequacy may mitigate these risks. Further research is needed to validate these f indings and explore interventions to improve outcomes in this vulnerable population.

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Cytokines and chemokines systemic levels are related to dialysis adequacy and creatinine clearance in patients with end-stage renal disease undergoing hemodialysis

Cited by 7 publications

References 61 publications

Thromboinflammatory response is increased in pancreas transplant alone versus simultaneous pancreas-kidney transplantation and early pancreas graft thrombosis is associated with complement activation

Thromboinflammatory response is increased in pancreas transplant alone versus simultaneous pancreas-kidney transplantation and early pancreas graft thrombosis is associated with complement activation

Study the Association between Dyslipidemia and CCL2 in Patients Undergoing Hemodialysis

Hemodialysis dose and long-term COVID-19 outcomes – a retrospective cohort study

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