Cytokines-adhesion molecules-invasive proteinases, the missing paracine/autocrine link in embryonic implantation

Simón, Carlos; Gimeno, María José Pena; Frances, Ana

doi:10.3109/09513599609116190

Cited by 24 publications

(41 citation statements)

References 4 publications

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“…The incoming blastocyst is already capable of secreting several parakrine signals (e.g. human chorionic gonadotropin (hCG), interleukin (IL)-1, and insulin-like growth factor (IGF)-2) that may modulate endometrial differentiation and function at the implantation site (Simon et al 1996;Tabibzadeh et al 1990;Tabibzadeh and Babaknia 1995). On the other hand, the endometrium is known to produce several cytokines and growth factors (e.g.…”

Section: The Embryo-endometrial Dialoguementioning

confidence: 99%

Is human chorionic gonadotropin directly involved in the regulation of human implantation?

Licht

Fluhr

Neuwinger³

et al. 2007

Molecular and Cellular Endocrinology

159

115

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Please cite this article as: Licht, P., Fluhr, H., Neuwinger, J., Wallwiener, D., Wildt, L., Is human chorionic gonadotropin directly involved in the regulation of human implantation? Molecular and Cellular Endocrinology (2007), doi:10.1016/j.mce.2006 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.A c c e p t e d M a n u s c r i p t A c c e p t e d M a n u s c r i p t 2 SummaryThe regulation of human implantation is not fully understood. HCG as one of the earliest embryonal signals may be a major regulator in the parakrine embryoendometrial communication. The expression of full-length hCG/LH-receptor mRNA could be demonstrated in human endometrium throughout the follicular and secretory phase of the menstrual cycle. In contrast, in early pregnancy decidua only truncated variants could be detected. To investigate direct effects of hCG on the human endometrium, an intrauterine microdialysis device was developed to measure parakrine mediators within the uterine cavity in vivo. Using this system, hCG was applied in the secretory phase and the endometrial response was evaluated. The administration of hCG (500 IU/ml) provoked a significant inhibition of intrauterine IGFBP-1 and M-CSF, while LIF, VEGF and MMP-9 were significantly stimulated.Taken together there appear to be multiple direct effects of hCG on the endometrium that precede the classical endocrine role of the hormone.

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Section: The Embryo-endometrial Dialoguementioning

confidence: 99%

Is human chorionic gonadotropin directly involved in the regulation of human implantation?

Licht

Fluhr

Neuwinger³

et al. 2007

Molecular and Cellular Endocrinology

159

115

View full text Add to dashboard Cite

show abstract

“…Much work on carbohydrates has identified several epitopes which are up-regulated in different species around the time of blastocyst attachment and which have in common numbers of glucosamine and fucose residues [74][75][76][77][78][79][80]. There is in addition emerging evidence that some integrins, cadherins and related receptors may be up-regulated in different membrane compartments in species so far examined which includes rodents, pigs, rabbits and humans during early pregnancy [14,63,[81][82][83][84][85]. Among these molecules, α v β 3 integrin appears to be particularly interesting and is either up regulated or becomes available due to the down regulation of MUC-1 in the plasma membrane of mouse, pig and human uterine epithelial cells during the receptive period [69,86,98].…”

Section: Common Behaviour Of Some Molecular Markers In the Plama Membmentioning

confidence: 99%

Uterine receptivity and the plasma membrane transformation

2004

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This review begins with a brief commentary on the diversity of placentation mechanisms, and then goes on to examine the extensive alterations which occur in the plasma membrane of uterine epithelial cells during early pregnancy across species. Ultrastructural, biochemical and more general morphological data reveal that strikingly common phenomena occur in this plasma membrane during early pregnancy despite the diversity of placental types-from epitheliochorial to hemochorial, which ultimately form in different species. To encapsulate the concept that common morphological and molecular alterations occur across species, that they are found basolaterally as well as apically, and that moreover they are an ongoing process during much of early pregnancy, not just an event at the time attachment, the term 'plasma membrane transformation' is suggested which also emphasises that alterations in this plasma membrane during early pregnancy are key to uterine receptivity. INTRODUCTIONContact between the plasma membrane of uterine epithelial cells and that of the trophoblast is a common beginning to implantation in most species studied so far. This is perhaps not surprising since uterine epithelial cells are the first site of contact between maternal and foetal tissue at the beginning of blastocyst attachment and implantation. The similarities in these early events of the uterine response during early pregnancy and placentation however, go further than mere contact between opposing surfaces. A now considerable body of evidence indicates that the behaviour of the plasma membrane of the uterine epithelial cells during early pregnancy has many common aspects across species ranging from viviparous lizards to human beings and that moreover, these similarities exist regardless of the placental type which ultimately develops. This review pays special attention to events at the cellular level in uterine epithelial cells and to the plasma membrane in particular, but does so within the wider context of uterine receptivity for implantation across species.

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“…A specific molecular cross-talk between embryo and endometrium has been reported during the human implantation process (5). Cytokines, such as IL-1, LIF, CSF-1, and IL-8, and their specific receptors, which are expressed in the endometrium and the embryo, are suggested to be involved therein (5)(6)(7).…”

mentioning

confidence: 99%

The Expression and Possible Roles of Chemokine CXCL11 and Its Receptor CXCR3 in the Human Endometrium

Hirota

Osuga

Koga

et al. 2006

The Journal of Immunology

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IFN-γ secreted by a human embryo and trophoblast cells during implantation is suggested to play an important role in implantation and pregnancy. In the present study, we explored expression and possible functions of CXCL11, a CXC chemokine strongly induced by IFN-γ, and its receptor CXCR3 in the human endometrium. Secreted CXCL11 protein was not detected in cultured endometrial stromal cells (ESC) but was detected in cultured endometrial epithelial cells (EEC). IFN-γ stimulated the protein levels of CXCL11 in a dose-dependent manner in EEC and ESC. CXCL11 secreted from EEC with 100 ng/ml IFN-γ was 220-fold of the control, and 100-fold as compared with that secreted from ESC with the same dose of IFN-γ. CXCR3 was expressed in EEC, ESC, and trophoblast cells. Addition of IFN-γ to EEC increased the chemotactic activity of its culture medium to trophoblast cells and T cells, and the effect was suppressed by immunoneutralization with Abs of three CXCR3 ligands, including anti-CXCL11 Ab. CXCL11 significantly increased BrdU incorporation of ESC, which was inhibited by a p42/44 MAPK pathway inhibitor PD98059. In contrast, CXCL11 significantly decreased BrdU incorporation and increased the release of lactate dehydrogenase and the positive staining of annexin V in EEC. These findings suggest that IFN-γ promotes implantation by stimulating EEC to produce CXCL11, which induces migration of trophoblast cells and T cells, proliferation of ESC, and apoptosis of EEC.

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Cytokines-adhesion molecules-invasive proteinases, the missing paracine/autocrine link in embryonic implantation

Cited by 24 publications

References 4 publications

Is human chorionic gonadotropin directly involved in the regulation of human implantation?

Is human chorionic gonadotropin directly involved in the regulation of human implantation?

Uterine receptivity and the plasma membrane transformation

The Expression and Possible Roles of Chemokine CXCL11 and Its Receptor CXCR3 in the Human Endometrium

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