Cytokine Therapy in Eye Disease

Expression of TNF-α, IL-1β, and IFN-γ in Staphylococcus epidermidis slime-positive experimental endophthalmitis is closely related to clinical inflammatory scores

“…Judging from results concerning other inflammatory processes [4,8], it would be reasonable to theorize a role of inflammatory cytokines in that condition. Cytokines are polypeptides that act as intercellular messengers [19,24], playing an important role in mediating the processes of inflammation and repair. Macrophages, lymphocytes, natural killers, and other immune cells, even endothelial cells, participate in the secretion of numerous signal molecules [9,26], which, in turn, recruit more inflammatory cells and regulate host immune responses to an injury or antigen invasion [20].…”

Vogt‐Koyanagi‐Harada disease associated with interferon alpha‐2b/ribavirin combination therapy

“…Being female and Latina, the patient fits the characteristic VKH profile. Both interferon and ribavirin can induce a TH1‐type response, the milieu associated with both VKH and experimental autoimmune uveoretinitis [10,19,20,48]. IFN‐alpha may also alter the expression of MHC class II antigens, another characteristic associated with the development of VKH disease [10,35].…”

Application of TNF-alpha inhibitors in treatment of uveitis associated with ankylosing spondylitis

“…Инфликсимаб с высокой специфичностью блокирует как циркулирующий, так и фиксированный на клеточных мембранах ФНОα. Впервые инфликсимаб применили для лечения увеита при ББ, о чем было сообщено в публикациях японских и греческих авторов [7,8]. Позднее появились работы об успешном применении инфликсимаба в лечении АС с проявлениями увеита [9,10].…”