Cytokine signature in chronic fatigue syndrome

Reply to Roerink et al: Methods for recruitment, serum separation, and storage were the same for patients and controls

“…Roerink et al (1) raise important and potential methodological biases that could have accounted for our finding regarding elevated TGF-β levels in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) (2). Here, we provide additional information as requested by Roerink et al (1) that supports that the elevation of TGF-β in patients with ME/CFS is most likely to be rooted in the biology of ME/CFS and not due to methodological issues.…”