Cytokine Responses to LTP Induction in the Rat Hippocampus: A Comparison of In Vitro and In Vivo Techniques

Jankowsky, Joanna L.; Derrick, Brian E.; Patterson, Paul H.

doi:10.1101/lm.32600

Cited by 89 publications

(60 citation statements)

References 48 publications

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“…Further, we have observed that the IL-6 gene is also over expressed during in vivo and in vitro LTP [5,6]. Other laboratories have confirmed these results [7]. More recently, we have detected that IL-1 receptor antagonist (IL-1ra) but not TNFa, is induced during LTP in freely moving rats (manuscript submitted).…”

Section: Increased Neuronal Activity Results In Il-1 and Il-6 Expressmentioning

confidence: 62%

Central and Peripheral Cytokines Mediate Immune-Brain Connectivity

Besedovsky¹,

Rey²

2010

Neurochem Res

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The immune system is a homeostatic system that contributes to maintain the constancy of the molecular and cellular components of the organism. Immune cells can detect the intrusion of foreign antigens or alteration of self-components and send information to the central nervous system (CNS) about this kind of perturbations, acting as a receptor sensorial organ. The brain can respond to such signals by emitting neuro/endocrine signals capable of affecting immune reactivity. Thus, the immune system, as other physiologic systems, is under brain control. Under disease conditions, when priorities for survival change, the immune system can, within defined limits, reset brain-integrated neuro-endocrine mechanisms in order to favour immune processes at the expenses of other physiologic systems. In addition, some cytokines initially conceived as immune products, such as IL-1 and IL-6, are also produced in the "healthy" brain by glial cells and even by some neurons. These and other cytokines have the capacity to affect synaptic plasticity acting as mediators of interactions between astrocytes and pre- and post-synaptic neurons that constitute what is actually defined as a tripartite synapse. Since the production of cytokines in the brain is affected by peripheral immune and central neural signals, it is conceivable that tripartite synapses can, in turn, serve as a relay system in immune-CNS communication.

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Section: Increased Neuronal Activity Results In Il-1 and Il-6 Expressmentioning

confidence: 62%

Central and Peripheral Cytokines Mediate Immune-Brain Connectivity

Besedovsky¹,

Rey²

2010

Neurochem Res

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“…A considerable body of experimental and clinical evidence suggests that IL-1β, IL-6, and TNF-α are induced by seizure activity and that these cytokines contribute to the formation of structural changes, such as neuronal damage and gliosis, after sustained seizure activity (49)(50)(51). Interestingly, in patients with recent generalized tonic-clonic seizures, the IL-6 level was selectively elevated in cerebrospinal fluid (CSF) and plasma without any change in IL-1β and TNF-α levels (52), and the elevated plasma IL-6 level was correlated with peripheral blood leukocyte counts and CRP (53).…”

Section: Discussionmentioning

confidence: 99%

High-Sensitivity C-Reactive Protein as an Associate of Clinical Subsets and Organ Damage in Systemic Lupus Erythematosus

Lee

Singh

Link

et al. 2008

Seminars in Arthritis and Rheumatism

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Objective-C-reactive protein (CRP) may play an anti-inflammatory role during the acute phase of inflammation, and is also used as a marker of inflammation associated with cardiovascular disease. In the present study, we investigated the association between high-sensitivity CRP (hsCRP) and systemic lupus erythematosus (SLE) manifestations, autoantibodies, and organ damage.Methods-In this cross-sectional study, 610 SLE patients from a prospective cohort had more than one hsCRP measurement. Organ damage was assessed using the Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) Damage Index. Multiple linear regression models were used to adjust for age, gender, ethnicity, disease duration, body mass index, education, disease activity, current prednisone dose, statin use, and estrogen use.Results-After adjusting for confounders, hsCRP was associated with myocarditis, cardiac murmur, interstitial pulmonary fibrosis, pulmonary hypertension, gastrointestinal lupus manifestations, and anemia. Anti-dsDNA antibodies and lupus anticoagulant were associated with hsCRP in unadjusted models, and these associations remained significant after adjustment for confounders. hsCRP levels were significantly higher in patients with pulmonary, musculoskeletal, and endocrine damage, and a total SLICC Damage Index score ≥1. After adjustment, hsCRP was associated with pulmonary, musculoskeletal, and total damage, but no longer with endocrine damage.Conclusions-hsCRP is associated with a broad range of clinical features and organ damage in SLE, particularly in the pulmonary and musculoskeletal systems. This association holds true independent of sociodemographic, disease activity, and treatment factors, and may be useful to identify high-risk SLE patients who would benefit from additional screening and surveillance studies.

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“…Furthermore, it must be noted that cytokines interact in a network where the function of one cytokine can be modified, modulated or substituted by others [42]. It has been hypothesized that IL-6 has an opposite role to IL-1 in synaptic plasticity and LTP maintenance, by inducing negative feedback and inhibiting the effects of IL-1 on LTP maintenance [6,38] and/or by curtailing synaptic improvement at neighboring synapses [43].…”

Section: Id Patients Controlsmentioning

confidence: 99%

Involvement of IL-6 and IL-1 receptor antagonist on intellectual disability

et al. 2014

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Imbalances in the regulation of pro-inflammatory cytokines have been increasingly correlated with several neurodevelopmental disorders and their role in neuronal development is being investigated. To assess the possible influence of cytokines on the onset of intellectual disability (ID), we studied the polymorphisms of thirteen proinflammatory cytokine genes in 81 patients and 61 healthy controls. We demonstrated a significant association of interleukin-6 (IL-6) single-nucleotide polymorphism (SNP) (-174 G/C and nt565 G/A), and interleukin-1 receptor antagonist (IL-1RA) (Mspa-I 11100) SNP with ID. Moreover, the IL-6 SNPs is an unfavorable genetic predisposition for females. The evaluation of circulating levels of IL-6 and IL-1RA showed that the serum concentrations of IL-6 were significantly higher in ID patients than in controls. These data suggest that functional cytokine gene polymorphisms may influence the development of ID.

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Cytokine Responses to LTP Induction in the Rat Hippocampus: A Comparison of In Vitro and In Vivo Techniques

Cited by 89 publications

References 48 publications

Central and Peripheral Cytokines Mediate Immune-Brain Connectivity

Central and Peripheral Cytokines Mediate Immune-Brain Connectivity

High-Sensitivity C-Reactive Protein as an Associate of Clinical Subsets and Organ Damage in Systemic Lupus Erythematosus

Involvement of IL-6 and IL-1 receptor antagonist on intellectual disability

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