Cytokine Response, Tract-Specific Fractional Anisotropy, and Brain Morphometry in Post-Stroke Cognitive Impairment

Кулеш, А. А.; Дробаха, В. Е.; Куклина, Е. М.; Nekrasova, I. V.; Shestakov, V. V.

doi:10.1016/j.jstrokecerebrovasdis.2018.02.004

Cited by 46 publications

(27 citation statements)

References 26 publications

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“…Inflammation played a crucial role in cognitive deficits (5–7); for instance, an elevated level of interleukin (IL)−6 was found to be associated with impaired executive function following stroke (8). And has also been implicated in Alzheimer's disease, serum IL-6 is negatively correlated with general cognitive functioning (9).…”

Section: Introductionmentioning

confidence: 99%

Elevated Serum Levels of Inflammation-Related Cytokines in Mild Traumatic Brain Injury Are Associated With Cognitive Performance

et al. 2019

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Mild traumatic brain injury (mTBI) is the most common neurological insult and leads to long-lasting cognitive impairments. The immune system modulates brain functions and plays a key role in cognitive deficits, however, the relationship between TBI-induced changes in inflammation-related cytokine levels and cognitive consequences is unclear. This was investigated in the present study in two cohorts of individuals within 1 week of mTBI (n = 52, n = 43) and 54 matched healthy control subjects. Patients with mTBI were also followed up at 1 and 3 months post-injury. Measures included cognitive assessments and a 9-plex panel of serum cytokines including interleukin (IL)-1β, IL-4, IL-6, IL-8, IL-10, IL-12, chemokine ligand 2 (CCL2), interferon-γ (IFN-γ), and tumor necrosis factor-α (TNF-α). The contribution of cytokine levels to cognitive function was evaluated by multivariate linear regression analysis. The results showed that serum levels of IL-1β, IL-6, and CCL2 were acutely elevated in mTBI patients relative to controls; CCL2 level was remained high over 3 months whereas IL-1β and IL-6 levels were declined by 3 months post-injury. A high level of CCL2 was associated with greater severity of post-concussion symptoms (which survived in the multiple testing correction); elevated IL-1β was associated with worse working memory in acute phase (which failed in correction); and acute high CCL2 level predicted higher information processing speed at 3 months post-injury (which failed in correction). Thus, acute serum cytokine levels are useful for evaluating post-concussion symptoms and predicting cognitive outcome in participants with mTBI.

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Section: Introductionmentioning

confidence: 99%

Elevated Serum Levels of Inflammation-Related Cytokines in Mild Traumatic Brain Injury Are Associated With Cognitive Performance

et al. 2019

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“…The results of the ROC curve showed that the possibility of predicting epilepsy recurrence by IL-6 was 70% [28]. Besides, IL-6 levels were also associated with the development of poststroke cognitive impairment ,patients with higher levels of IL-6 had lower MMSE scores three months after stroke [29].…”

Section: Interleukinmentioning

confidence: 97%

Advances in the Development of Biomarkers for Poststroke Epilepsy

Liang

Zhang

Geng

2021

BioMed Research International

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Stroke is the main cause of acquired epilepsy in elderly people. Poststroke epilepsy (PSE) not only affects functional recovery after stroke but also brings considerable social consequences. While some factors such as cortical involvement, hemorrhagic transformation, and stroke severity are associated with increased seizure risk, so far that remains controversial. In recent years, there are an increasing number of studies on potential biomarkers of PSE as tools for diagnosing and predicting epileptic seizures. Biomarkers such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), glutamate, and S100 calcium-binding protein B (S100B) in blood are associated with the occurrence of PSE. This review is aimed at summarizing the progress on potential biomarkers of PSE.

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“…Для прогнозирования восстановления речи после инсульта определенную ценность имеет изучение интегральности дугообразного пучка [10]. В предыдущих исследованиях мы определяли роль нарушения микроструктуры различных проводников в развитии постинсультных когнитивных нарушений (КН) [11,12].…”

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“…Показатели FA ЦП достигают пика лишь к 42 годам, что объясняет его важность для формирования когнитивных и эмоциональных навыков в течение жизни и позволяет рассматривать в качестве одного из маркеров церебрального резерва [23,22]. В нашей предыдущей работе показано, что в остром периоде ИИ пациенты с дизрегуляторными и смешанными КН отличаются от больных с нормальным когнитивным статусом, в том числе со снижением показателей FA контралатерального ЦП [11]. Ранее C. Santiago и соавт.…”

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Role of cerebral reserve assessed using diffusion-weighted magnetic resonance imaging in determining the rehabilitation potential of acute ischemic stroke

Кулеш

Дробаха

Sobyanin

et al. 2019

RJTAO

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Fractional anisotropy (FA) estimated using diffusion tensor magnetic resonance imaging (dMRI) is considered as a promising biomarker in ischemic stroke (IS). The basis of this study is the assumption that the assessment of FA indices for different white matter tracts will be able to predict the main aspects of the rehabilitation potential even without determining the structural and functional bases of these influences.Objective: to study the diagnostic significance of changes in FA indices to assess various aspects of the rehabilitation potential in acute IS.Patients and methods. Examinations were made in 100 patients with IS and in 10 individuals without stroke and cognitive impairment. All the patients underwent dMRI and assessments of rehabilitation potential indicators on days 3 and 10 of the disease and at discharge.Results and discussion. The indices of FA of the ipsilateral upper longitudinal and cingulum bundles, FA and the size of an infarct focus, asymmetry of FA of the cingulum bundle (rFA), corticospinal tract (at the level of the knee of the internal capsule and bridge) and the anterior limb of the internal capsule, as well as the FA of the splenium and knee of the internal capsule of the intact hemisphere are of the most value for the functional outcome of acute IS. The microstructure of these zones determines the state of most rehabilitation domains. With respect to global outcome, the integrity of the associative tracts of the affected hemisphere is more valuable than the microstructure of the intact hemisphere and rFA. The tracts of the intact hemisphere are of particular importance for the restoration of complex rehabilitation spheres, such as cognitive status and daily living and social skills, which is necessary to ensure patient independence.Conclusion. The FA indices of the tracts under study seem to be a clinically acceptable biomarker of various aspects of the rehabilitation potential in acute IS.

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Cytokine Response, Tract-Specific Fractional Anisotropy, and Brain Morphometry in Post-Stroke Cognitive Impairment

Cited by 46 publications

References 26 publications

Elevated Serum Levels of Inflammation-Related Cytokines in Mild Traumatic Brain Injury Are Associated With Cognitive Performance

Elevated Serum Levels of Inflammation-Related Cytokines in Mild Traumatic Brain Injury Are Associated With Cognitive Performance

Advances in the Development of Biomarkers for Poststroke Epilepsy

Role of cerebral reserve assessed using diffusion-weighted magnetic resonance imaging in determining the rehabilitation potential of acute ischemic stroke

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