Cytokine Response to Diet and Exercise Affects Atheromatous Matrix Metalloproteinase-2/9 Activity in Mice

Abstract

plaque, even if the animals remained on a high fat diet and plaque growth was not attenuated. 5 The study suggested that circulating adiponectin and soluble vascular cell adhesion molecule-1 (sVCAM-1) might be related to the reduced MMP activity in atheromas, but the mechanisms for this effect were not known. The present study aims to address the mechanisms leading to this observation, relating the MMP-modulating effect of diet and exercise to cytokine homeostasis. We also considered body mass and visceral fat amount, which could be affected by diet and exercise, and ultimately contribute to obesity-related re-A theromatous matrix metalloproteinase (MMP) activity is related to plaque vulnerability and rupture, the final common pathway for the thromboembolic complications of atherosclerosis, such as ischemic stroke or myocardial infarction. 1-4 Identifying the principal factors that affect atheromatous MMP activity may help predict and prevent these events.Using an MMP-activatable protease reporter, we previously described that 10-weeks of treadmill exercise reduced in vivo atheromatous MMP-2/9 activity in Apolipoprotein-E (ApoE) knock-out (ApoE −/− ) mice with pre-existing Background: The aim of this study is to identify the principal circulating factors that modulate atheromatous matrix metalloproteinase (MMP) activity in response to diet and exercise.

Tumor‐Targeting Glycol Chitosan Nanoparticles for Cancer Heterogeneity

“…Several reviews have provided more detailed characterization of GC. [ 15,17 ] Importantly, the amine groups of GC remain unaffected for future modification while GC retains uniquely appealing features of chitosan such as their biocompatibility, nontoxicity, and biodegradability ( Figure ). These amine groups in the backbone of hydrophilic GC facilitate the introduction of various hydrophobic moieties to GC, which is a crucial characteristic for the development of self‐assembled nanoparticles that are potentially satisfied for drug delivery applications.…”