Cytokine receptors and hematopoietic differentiation

Robb, Lorraine

doi:10.1038/sj.onc.1210756

Cited by 137 publications

(113 citation statements)

References 83 publications

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“…Cytokines play an important role during the development of hematopoietic cells, by supporting proliferation, survival, or lineage commitment (26). Only few cytokines are described that are required for the development and maintenance of ILCs under steady-state conditions.…”

mentioning

confidence: 99%

Flt3 Ligand Regulates the Development of Innate Lymphoid Cells in Fetal and Adult Mice

Baerenwaldt

Burg

Kreuzaler

et al. 2016

The Journal of Immunology

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Flt3 ligand (Flt3L) promotes survival of lymphoid progenitors in the bone marrow and differentiation of dendritic cells (DCs), but its role in regulating innate lymphoid cells (ILCs) during fetal and adult life is not understood. By using Flt3L knockout and transgenic mice, we demonstrate that Flt3L controls ILC numbers by regulating the pool of α4β7− and α4β7+ lymphoid tissue inducer cell progenitors in the fetal liver and common lymphoid progenitors in the bone marrow. Deletion of flt3l severely reduced the number of fetal liver progenitors and lymphoid tissue inducer cells in the neonatal intestine, resulting in impaired development of Peyer’s patches. In the adult intestine, NK cells and group 2 and 3 ILCs were severely reduced. This effect occurred independently of DCs as ILC numbers were normal in mice in which DCs were constitutively deleted. Finally, we could show that administration of Flt3L increased the number of NKp46− group 3 ILCs in wild-type and even in Il7−/− mice, which generally have reduced numbers of ILCs. Taken together, Flt3L significantly contributes to ILC and Peyer’s patches development by targeting lymphoid progenitor cells during fetal and adult life.

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mentioning

confidence: 99%

Flt3 Ligand Regulates the Development of Innate Lymphoid Cells in Fetal and Adult Mice

Baerenwaldt

Burg

Kreuzaler

et al. 2016

The Journal of Immunology

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“…The different mature hematopoietic cells are usually classified in lymphoid and myeloid lineages. They are regulated by distinct cytokines acting on multipotential progenitors and their committed offspring [12,13] (Fig. 1).…”

Section: Regulation Of Erythropoiesismentioning

confidence: 99%

Linking anemia to inflammation and cancer: The crucial role of TNFα

Buck

Morceau

Grigorakaki

et al. 2009

Biochemical Pharmacology

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Erythropoiesis is considered as a multistep and tightly regulated process under the control of a series of cytokines including erythropoietin (Epo). Epo activates specific signaling pathways and leads to activation of key transcription factors such as GATA-1, in order to ensure erythroid differentiation. Deregulation leads to a decreased number of red blood cells, a hemoglobin deficiency, thus a limited oxygen-carrying capacity in the blood. Anemia represents a frequent complication in various diseases such as cancer or inflammatory diseases. It reduces both quality of life and prognosis in patients. Tumor necrosis factor alpha (TNFα) was described to be involved in the pathogenesis of inflammation and cancer related anemia. Blood transfusions and erythroid stimulating agents (ESAs) including human recombinant Epo (rhuEpo) are currently used as efficient treatments. Moreover, the recently described conflicting effects of ESAs in distinct studies require further investigations on the molecular mechanisms involved in TNFα-caused anemia. The present study aims to evaluate the current knowledge and the importance of the effect of the proinflammatory cytokine TNFα on erythropoiesis in inflammatory and malignant conditions.

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“…9,55 Membrane-associated receptors and integrins are numerous, and their role in hematopoiesis is a field of investigation under constant flux that has regularly been reviewed in detail. 51,[56][57][58][59][60][61][62][63][64][65][66][67][68][69][70] We will briefly highlight major points of interest for several of the most studied receptors below and in Table 1.…”

Section: Regulation Of Expression Via Cell Membrane Proteinsmentioning

confidence: 99%

Gene expression changes in normal haematopoietic cells

Lionberger¹,

Stirewalt²

2009

Best Practice & Research Clinical Haematology

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The complexity of the healthy hematopoietic system is immense, and as such, one must understand the biology driving normal hematopoietic expression profiles when designing experiments and interpreting expression data that involves normal cells. This chapter seeks to present an organized approach to the use and interpretation of gene profiling in normal hematopoiesis and broadly illustrates the challenges of selecting appropriate controls for high-throughput expression studies.

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Cytokine receptors and hematopoietic differentiation

Cited by 137 publications

References 83 publications

Flt3 Ligand Regulates the Development of Innate Lymphoid Cells in Fetal and Adult Mice

Flt3 Ligand Regulates the Development of Innate Lymphoid Cells in Fetal and Adult Mice

Linking anemia to inflammation and cancer: The crucial role of TNFα

Gene expression changes in normal haematopoietic cells

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