Cytokine profiling of prostatic fluid from cancerous prostate glands identifies cytokines associated with extent of tumor and inflammation

Fujita, Kazutoshi; Ewing, Charles M.; Sokoll, Lori J.; Elliott, Debra J.; Cunningham, Mark D.; Marzo, Angelo M. De; Isaacs, William B.; Pavlovich, Christian P.

doi:10.1002/pros.20755

Cited by 51 publications

(39 citation statements)

References 32 publications

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“…these results are consistent with previous studies that found that plasma levels of tnF-α, Il-10 and Il-18 are increased in advanced-stage Hcc (36-41). similar results have also been reported for advanced-stage gastric cancer (42-45) and prostate cancer (46). these previous results combined with our present results strongly indicate that higher levels of plasma tnF-α, Il-10 and Il-18 correlate to a poor prognosis in cancer patients.…”

Section: Discussionsupporting

confidence: 92%

Altered cytokine levels and increased CD4+CD57+ T cells in the peripheral blood of hepatitis C virus-related hepatocellular carcinoma patients

et al. 2011

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+ αβtcr + cells (cD57 + t cells), showed a significant inverse correlation with pB-IFn-γ-producing capability. the present results suggest that an increase in cD4 + cD57 + t cells controls the capability of pB to produce the antitumor cytokine IFn-γ and that pB-IFn-γ production is impaired with Hcc tumor progression. IntroductionHepatocellular carcinoma (HCC) is the fifth most common cancer in men and the eighth most common cancer in women worldwide. Hcc is highly prevalent in patients with chronic liver diseases resulting mainly from hepatitis B virus (HBV) or hepatitis c virus (HcV) infection, and its incidence is now increasing. In Japan, Hcc is the third most common cause of mortality, and the most frequent cause of Hcc is chronic infection with HcV (1,2 A b b re vi a t i o n s:A lt, a la n i n e t r a n s a m i n a s e; A F p, α

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Section: Discussionsupporting

confidence: 92%

Altered cytokine levels and increased CD4+CD57+ T cells in the peripheral blood of hepatitis C virus-related hepatocellular carcinoma patients

et al. 2011

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“…The massive secretion of IL-6 in the pancreas of ENO1-vaccinated mice (data not shown) may explain the increase of Th17 rather than FoxP3 ϩ cells. 24 Th17 cells recruit neutrophils and eosinophils, 25 also present in pancreatic tumor lesions from empty-vaccinated mice (data not shown), and this native immune response partly impeded tumor progression, particularly at the beginning; indeed, at 24 weeks of age, both empty-and ENO1-vaccinated mice presented a lower percentage of transformed pancreatic ducts compared with untreated mice. However, only the combination of the innate and acquired immune responses induced by ENO1 vaccination was able to significantly delay tumor progression.…”

Section: Pancreasmentioning

confidence: 92%

Vaccination With ENO1 DNA Prolongs Survival of Genetically Engineered Mice With Pancreatic Cancer

et al. 2013

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See Covering the Cover synopsis on page 862. BACKGROUND & AIMS:Pancreatic ductal adenocarcinoma (PDA) is an aggressive tumor, and patients typically present with late-stage disease; rates of 5-year survival after pancreaticoduodenectomy are low. Antibodies against ␣-enolase (ENO1), a glycolytic enzyme, are detected in more than 60% of patients with PDA, and ENO1-specific T cells inhibit the growth of human pancreatic xenograft tumors in mice. We investigated whether an ENO1 DNA vaccine elicits antitumor immune responses and prolongs survival of mice that spontaneously develop autochthonous, lethal pancreatic carcinomas. METHODS:We injected and electroporated a plasmid encoding ENO1 (or a control plasmid) into Kras G12D /Cre (KC) mice and Kras G12D /Trp53 R172H /Cre (KPC) mice at 4 weeks of age (when pancreatic intraepithelial lesions are histologically evident). Antitumor humoral and cellular responses were analyzed by histology, immunohistochemistry, enzyme-linked immunosorbent assays, flow cytometry, and enzyme-linked immunosorbent spot and cytotoxicity assays. Survival was analyzed by Kaplan-Meier analysis. RESULTS: The ENO1 vaccine induced antibody and a cellular response and increased survival times by a median of 138 days in KC mice and 42 days in KPC mice compared with mice given the control vector. On histologic analysis, the vaccine appeared to slow tumor progression. The vaccinated mice had increased serum levels of anti-ENO1 immunoglobulin G, which bound the surface of carcinoma cells and induced complement-dependent cytotoxicity. ENO1 vaccination reduced numbers of myeloid-derived suppressor cells and T-regulatory cells and increased T-helper 1 and 17 responses. CONCLU-SIONS: In a genetic model of pancreatic carcinoma, vaccination with ENO1 DNA elicits humoral and cellular immune responses against tumors, delays tumor progression, and significantly extends survival. This vaccination strategy might be developed as a neoadjuvant therapy for patients with PDA.

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“…ICAM-1 has an important role in enhancing T cell killing via cell-cell adhesion to lymphocyte function-associated antigen (LFA)-1 and by directly co-stimulating activated T cells (Garnett et al, 2004;Baluna et al, 2006). PCa cells express ICAM-1 and VCAM-1 and in tissue areas of high lymphocyte and neutrophil accumulation the expression of ICAM-1 is significantly elevated (Fujita et al, 2008;Rokhlin & Cohen, 1995). These data suggest that ICAM-1 upregulation by IR may facilitate immune responses by recruiting lymphocytes and macrophages to the tumour site.…”

Section: Irradiated Tumour Cells Become Sensitive To Immune Cell Attackmentioning

confidence: 99%

“…IL-12 is secreted by mature DC and macrophages and required for IFN and TNF production from T cells and mediates a Th1-type immune response. Adenovirus-derived IL-12 plus RT significantly increased local antitumour and systemic antimetastatic effects in a preclinical model of metastatic PCa when compared to either treatment alone (Fujita et al, 2008). This antimetastatic activity is due to the antitumoural activities of natural killer (NK) cells.…”

Section: Pre-clinical Modelsmentioning

confidence: 99%

Combination of Immunotherapy & Radiotherapy for the Treatment of Prostate Cancer

Tabi¹,

Spary²,

Staffurth³

2011

Prostate Cancer - Diagnostic and Therapeutic Advances

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Cytokine profiling of prostatic fluid from cancerous prostate glands identifies cytokines associated with extent of tumor and inflammation

Cited by 51 publications

References 32 publications

Altered cytokine levels and increased CD4+CD57+ T cells in the peripheral blood of hepatitis C virus-related hepatocellular carcinoma patients

Altered cytokine levels and increased CD4+CD57+ T cells in the peripheral blood of hepatitis C virus-related hepatocellular carcinoma patients

Vaccination With ENO1 DNA Prolongs Survival of Genetically Engineered Mice With Pancreatic Cancer

Combination of Immunotherapy & Radiotherapy for the Treatment of Prostate Cancer

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