Cytokine profiles of bronchoalveolar lavage fluid in patients with pneumocystis pneumonia

Tasaka, Sadatomo; Kobayashi, Seiki; Kamata, Hirofumi; Kimizuka, Yoshifumi; Fujiwara, Hiroshi; Funatsu, Yohei; Mizoguchi, Kosuke; Ishii, Makoto; Takeuchi, Tsutomu; Hasegawa, Naoki

doi:10.1111/j.1348-0421.2010.00229.x

Cited by 18 publications

(19 citation statements)

References 31 publications

(43 reference statements)

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“…Community-acquired pneumonia is pneumonia acquired infectiously from normal social contact, as opposed to being acquired during hospitalization (termed hospital-acquired pneumonia). Increased serum HMGB1 level is caused by bacteria or virus in both community-acquired and hospital-acquired pneumonia (Achouiti et al, 2013; Angus et al, 2007; Entezari et al, 2012; Ito et al, 2011; Kosai et al, 2008; Sharma et al, 2013; Tasaka et al, 2010; van Zoelen et al, 2008; Zhou et al, 2011d). Both RAGE and TLR4 play roles in the regulation of HMGB1-mediated inflammatory response during pneumonia (Achouiti et al, 2013; Entezari et al, 2012; Ramsgaard et al, 2011).…”

Section: Hmgb1 and Diseasementioning

confidence: 99%

HMGB1 in health and disease

Kang

Chen

Zhang

et al. 2014

Molecular Aspects of Medicine

772

795

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Complex genetic and physiological variations as well as environmental factors that drive emergence of chromosomal instability, development of unscheduled cell death, skewed differentiation, and altered metabolism are central to the pathogenesis of human diseases and disorders. Understanding the molecular bases for these processes is important for the development of new diagnostic biomarkers, and for identifying new therapeutic targets. In 1973, a group of non-histone nuclear proteins with high electrophoretic mobility was discovered and termed High-Mobility Group (HMG) proteins. The HMG proteins include three superfamilies termed HMGB, HMGN, and HMGA. High-mobility group box 1 (HMGB1), the most abundant and well-studied HMG protein, senses and coordinates the cellular stress response and plays a critical role not only inside of the cell as a DNA chaperone, chromosome guardian, autophagy sustainer, and protector from apoptotic cell death, but also outside the cell as the prototypic damage associated molecular pattern molecule (DAMP). This DAMP, in conjunction with other factors, thus has cytokine, chemokine, and growth factor activity, orchestrating the inflammatory and immune response. All of these characteristics make HMGB1 a critical molecular target in multiple human diseases including infectious diseases, ischemia, immune disorders, neurodegenerative diseases, metabolic disorders, and cancer. Indeed, a number of emergent strategies have been used to inhibit HMGB1 expression, release, and activity in vitro and in vivo. These include antibodies, peptide inhbitiors, RNAi, anti-coagulants, endogenous hormones, various chemical compounds, HMGB1-receptor and signaling pathway inhibition, artificial DNAs, physical strategies including vagus nerve stimulation and other surgical approaches. Future work further investigating the details of HMGB1 localizationtion, structure, post-translational modification, and identifccation of additional partners will undoubtedly uncover additional secrets regarding HMGB1’s multiple functions.

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Section: Hmgb1 and Diseasementioning

confidence: 99%

HMGB1 in health and disease

Kang

Chen

Zhang

et al. 2014

Molecular Aspects of Medicine

772

795

View full text Add to dashboard Cite

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“…These studies suggest that the actual cause of the immunosuppression predisposing to the infection may have as much impact on the cytokine profile as the organism itself [23,24]. This latter study suggests that P. jiroveci infection is associated with reduced macrophages in alveoli and elevated IL-6.…”

mentioning

confidence: 51%

Severe Pneumonia in HIV-infected Infants–Clinical and Immunological Correlates. Trying to Improve Diagnosis and thereby Survival

Green¹

2013

J Antivir Antiretrovir

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“…These studies suggest that the actual cause of the immunosuppression predisposing to the infection may have as much impact on the cytokine profile as the organism itself. [26,27] This latter study suggests that P. jiroveci infection is associated with reduced macrophages in alveoli and elevated IL-6. However, IP-10 was not measured in that study.…”

Section: Discussionmentioning

confidence: 81%

Cytokine profile and clinical correlates in HIV-exposed infants with severe (hypoxic) pneumonia

Green

Terclanche²,

Becker³

et al. 2016

S Afr Res J

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Introduction. Severe pneumonia in infants who are HIV-infected is a common problem in many parts of the developing world, especially sub-Saharan Africa. What has been missing from previous studies of severe pneumonia in HIV-infected infants, however, is a description of the host inflammatory response and cytokine/chemokine profile that accompanies this disease.Objective. To describe the cytokine profiles associated with severe hypoxic pneumonia in HIV-infected infantsMethods. In a cohort of HIV-infected children diagnosed clinically with severe hypoxic pneumonia, paired serum and sputum cytokines were tested. A control group of HIV-infected children with bronchiectasis contributed matching controls.Results. A total of 100 infants (mean age 2.8 months) with a clinical diagnosis of severe hypoxic pneumonia were included in this study. IP-10 was markedly elevated in both sputum (mean 560.77pg/ml) and serum (mean 9091.14pg/ml), while IP-10 was elevated in serum (mean 39.55 pg/ml), with both these cytokines being significantly higher than in stable children with HIV-related bronchiectasis.Conclusion. This study of HIV-infected infants with severe hypoxic pneumonia suggests that IL-10 and IP-10 are associated with more severe lung disease. However, further investigation of this association is required.

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Cytokine profiles of bronchoalveolar lavage fluid in patients with pneumocystis pneumonia

Cited by 18 publications

References 31 publications

HMGB1 in health and disease

HMGB1 in health and disease

Severe Pneumonia in HIV-infected Infants–Clinical and Immunological Correlates. Trying to Improve Diagnosis and thereby Survival

Cytokine profile and clinical correlates in HIV-exposed infants with severe (hypoxic) pneumonia

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