Cytokine profiles in cord blood in relation to prenatal traffic‐related air pollution: The NELA cohort

García-Serna, Azahara M; Martín‐Orozco, Elena; Jiménez‐Guerrero, Pedro; Hernández‐Caselles, Trinidad; Pérez‐Fernández, Virginia; Cantero‐Cano, Esther; Muñoz-García, María; Molina‐Ruano, María Dolores; Rojo‐Atenza, Encarna; García‐Marcos, Luis; Morales, Eva; Candel-Torralba, M. E.; García‐Marcos, Luis; Gimenez-Banon, M. J.; Martínez-Torres, Antonela; Sánchez-Solís, Manuel Rolandi; Nieto, Anı́bal; Prieto-Sánchez, María T; Sánchez-Ferrer, María Luisa; Fernanez-Palacios, L.; Gomez-Gomez, V. P.; Martínez‐Graciá, Carmen; Peso-Echarri, Patricia; Ros-Berruezo, G.; Santaella‐Pacual, M; Gázquez, Antonio; Larqué, Elvira; Pastor-Fajardo, M. T.; Sánchez-Campillo, María; Serrano-Munuera, A.; Zornoza-Moreno, Matilde; Adomnei, E; Arense-Gonzalo, J. J.; Mendiola, Jaime; Navarro-Lafuente, Fuensanta; Torres-Cantero, A. M.; Salvador-García, Carme; Segovia-Hernández, M.; Yagüe-Guirao, Genoveva; Valero-Guillén, P. L.; Aviles-Plaza, F. V.; Cabezas‐Herrera, Juan; Martínez‐López, Alicia; Martínez-Villanueva, Miriam; Noguera-Velasco, José Antonio; Franco-Garcia, A.; Garcia‐Serna, AM; Norte-Muñoz, Maria; Cánovas, Manuel Sánchez; Diego, Teresa De; Pastor, JM; Sola-Martínez, R. A.; Esteban-Gil, A.; Fernández‐Breis, JT; Alcántara, M. V.; Hernández, Sandra; Lopez-Soler, Concepción

doi:10.1111/pai.13732

Cited by 13 publications

(12 citation statements)

References 53 publications

(112 reference statements)

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“…Weng et al showed that abnormal mitochondrial respiratory chain metabolism also leads to impairment of invariant natural killer T cell (iNKT) preactivation and reduced T cell receptor (TCR) signaling ( 33 ). This is consistent with the reports of neonatal immune deficiency due to air pollution exposure ( 34 ). The current study demonstrated that Uqcrfs1 protein expression was diminished after environmental exposure to waterfall forest aerosols, further weakening the electron transport activity.…”

Section: Discussionsupporting

confidence: 93%

Effects of short-term waterfall forest aerosol air exposure on rat lung proteomics

Zhu¹,

Zhao²,

Zhu³

et al. 2022

Ann Transl Med

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Background: Chronic exposure to airborne microparticles has been shown to increase the incidence of several chronic diseases. Previous studies have found that waterfall forest aerosols contribute to a diminished immune stress response in patients with asthma. However, the specific effects of short-term waterfall forest aerosol exposure on lung proteins have not been fully elucidated.Methods: This study used liquid chromatography-tandem mass spectrometry (LC-MS) to analyze changes in protein expression in the lungs of rats exposed to short-term waterfall forest aerosol environments. Specific protein markers were identified using bioconductivity analysis screening and validated using immunohistochemistry.Results: Waterfall forest aerosol environment exposure on day 5 downregulated the expression of the classical inflammatory pathway nuclear factor κB (NF-κB) signaling pathway. As the waterfall forest aerosol environment increased due to the duration of exposure, it was involved in oxidative phosphorylation and then hormone signaling in lung cells from the very beginning. In contrast, at day 15 of exposure, there is an effect on the regulation of the immune-related high-affinity IgE receptor pathway. In addition, iron-sulfur Rieske protein (Uqcrfs1), mitochondrial Tu translation elongation factor (Tufm) and ribosomal protein L4 (Rpl4) were identified as possible bioindicators for the evaluation of air quality.Conclusions: These results provide a comprehensive proteomic analysis that supports the positive contribution of a good air quality environment to lung health.

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Section: Discussionsupporting

confidence: 93%

Effects of short-term waterfall forest aerosol air exposure on rat lung proteomics

Zhu¹,

Zhao²,

Zhu³

et al. 2022

Ann Transl Med

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show abstract

“…Although statistically not significant, the recent epidemiological study from García-Serna et al 5 found that odds of detectable concentration of IL-17F tended to be decreased in the cord blood of infants exposed to higher air pollution during the pregnancy. Thus, the mouse model data, 3 our data from human infants as well as data from García-Serna et al 5 potentially reflect a suppressive effect on IL-17a levels during mouse and human immune system development, respectively. We speculate that not all life stages are equally influenced and some life stages, such as the perinatal period, are more susceptible due to the immaturity of the immune system.…”

Section: E T T E R T O T H E E D I T O R Ambient Prenatal Air Polluti...mentioning

confidence: 81%

Ambient prenatal air pollution exposure is associated with low cord blood IL‐17a in infants

Gorlanova

Oller

Marten

et al. 2023

Pediatric Allergy Immunology

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“…On the basis of the prior knowledge obtained from previous scientific literature, additional covariates were further selected for statistical analysis . Ultimately, maternal age, education level, passive smoking, income, gestational age at delivery, BMI before pregnancy, and parity were included in the models as final covariates.…”

Section: Discussionmentioning

confidence: 99%

Gestational Exposure to Ambient Particulate Matter Alters Neonatal Cytokines

Zhang

et al. 2022

Environ. Sci. Technol. Lett.

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The role of maternal exposure to fine particulate matter (PM 2.5 ) in the development of the fetal immune system remains unclear. A total of 482 mother−infant pairs were included in our longitudinal birth cohort study. Maternal PM 2.5 exposure during the first trimester was assessed, and 27 neonatal cytokines were detected. This study was designed to evaluate the effects of maternal PM 2.5 exposure on fetal immune system development and to identify the most heavily weighted component. Negative associations were observed between maternal PM 2.5 exposure and neonatal IL7 [β = −0.

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Cytokine profiles in cord blood in relation to prenatal traffic‐related air pollution: The NELA cohort

Abstract: and Fondos FEDER. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Cited by 13 publications

References 53 publications

Effects of short-term waterfall forest aerosol air exposure on rat lung proteomics

Effects of short-term waterfall forest aerosol air exposure on rat lung proteomics

Ambient prenatal air pollution exposure is associated with low cord blood IL‐17a in infants

Gestational Exposure to Ambient Particulate Matter Alters Neonatal Cytokines

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