Cytokine profiles in axial spondyloarthritis

Madej, Marta; Nowak, Beata; Świerkot, Jerzy; Sokolik, Renata; Chlebicki, Arkadiusz; Korman, Lucyna; Woytala, Patryk; Lubiński, Łukasz; Wiland, Piotr

doi:10.5114/reum.2015.50551

Cited by 20 publications

(12 citation statements)

References 25 publications

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“…Potential contribution of the IL-23/IL-17 axis to IBD and spondyloarthritis pathology is supported by recent observations, reporting significantly increased concentrations and/or enhanced expression of the IL-23/IL-17 axis-associated cytokines in the sera [ 26 ] and synovial fluids of patients with spondyloarthritis as well as in the intestinal mucosa of IBD patients [ 11 , 12 ]. There is, however, discrepancy concerning association of IL-23 levels with clinical activity of spondyloarthritis [ 24 , 27 ].…”

Section: Discussionmentioning

confidence: 76%

Inflammatory bowel disease-related arthritis – clinical evaluation and possible role of cytokines

Dmowska-Chalaba¹,

Kontny²

2015

Reumatologia

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ObjectivesIn inflammatory bowel disease (IBD), characterized by chronic mucosal inflammation, rheumatic abnormalities ranging from arthralgia to spondyloarthritis (SpA) are the most common extraintestinal manifestations. The pathogenesis of IBD-related arthritis is unclear. In this study, we search for clinical and immunological differences between patients with IBD-associated spondyloarthritis and IBD patients without SpA symptoms.Material and methodsPatients with an established diagnosis of IBD, suffering from Leśniowski-Crohn disease (L-CD, n = 24) or ulcerative colitis (UC, n = 27), were enrolled in the study. Clinical evaluation of patients, based on medical history, blood tests, physical and radiological examinations, allowed two subgroups of patients to be established. One subgroup comprised patients fulfilling criteria for both IBD and SpA (IBD + SpA, n = 29), while the other included IBD patients with arthralgia only (IBD, n = 22). Serum concentrations of interleukins (IL-6, IL-10, IL-21, IL-22, IL-23) and interferon γ (IFN-γ) were measured by specific enzyme-linked immunosorbent assays (ELISA).ResultsPatients with IBD + SpA were characterized by shorter disease duration (3 vs. 9 years), higher frequency of HLA-B27 positivity (60.7% vs. 4.5%) and uveitis (20.7% vs. 0%), compared with the IBD subgroup. The serum concentrations of C-reactive protein (CRP) and tested cytokines did not differ between IBD + SpA and IBD patients, or between L-CD and UC groups. However, in the IBD + SpA subgroup there was weak to moderate positive correlation between serum concentrations of CRP and several cytokines (IL-6, IL-21, IFN-γ), and additional moderate positive correlation between serum concentrations of IL-23 and clinical activity of SpA. By contrast, in IBD subgroup a strong inverse correlation between serum concentrations of Interleukin 23 and CRP was found.ConclusionsIBD-related spondyloarthritis occurs relatively early, affects mostly HLA-B27(+) individuals, and is often accompanied by ocular involvement. In these patients several circulating cytokines are associated with systemic inflammation. IL-23 seems to be protective in IBD while detrimental in IBD-related spondyloarthritis.

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Section: Discussionmentioning

confidence: 76%

Inflammatory bowel disease-related arthritis – clinical evaluation and possible role of cytokines

Dmowska-Chalaba¹,

Kontny²

2015

Reumatologia

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“…Many studies have shown that various immune-related cells, via their secreting cytokines and molecules, may play crucial roles in AS pathogenesis ( Mei et al, 2011 ; Liu et al, 2015 ; Madej et al, 2015 ; Sveaas et al, 2015 ; Wang et al, 2016 ; Yang et al, 2016 ; Wang et al, 2018 ). These data indicate that both innate and adaptive immune cells are involved in AS pathogenesis.…”

Section: Immune Dysfunctions In Patients With Asmentioning

confidence: 99%

The Potential Role of Genetics, Environmental Factors, and Gut Dysbiosis in the Aberrant Non-Coding RNA Expression to Mediate Inflammation and Osteoclastogenic/Osteogenic Differentiation in Ankylosing Spondylitis

Liao

Tsai

Lai

et al. 2022

Front. Cell Dev. Biol.

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Ankylosing spondylitis (AS) or radiographic axial spondyloarthritis is a chronic immune-mediated rheumatic disorder characterized by the inflammation in the axial skeleton, peripheral joints, and soft tissues (enthesis, fascia, and ligament). In addition, the extra-skeletal complications including anterior uveitis, interstitial lung diseases and aortitis are found. The pathogenesis of AS implicates an intricate interaction among HLA (HLA-B27) and non-HLA loci [endoplasmic reticulum aminopeptidase 1 (ERAP1), and interleukin-23 receptor (IL23R), gut dysbiosis, immune plasticity, and numerous environmental factors (infections, heavy metals, stress, cigarette smoking, etc.) The latter multiple non-genetic factors may exert a powerful stress on epigenetic regulations. These epigenetic regulations of gene expression contain DNA methylation/demethylation, histone modifications and aberrant non-coding RNAs (ncRNAs) expression, leading to inflammation and immune dysfunctions. In the present review, we shall discuss these contributory factors that are involved in AS pathogenesis, especially the aberrant ncRNA expression and its effects on the proinflammatory cytokine productions (TNF-α, IL-17 and IL-23), T cell skewing to Th1/Th17, and osteoclastogenic/osteogenic differentiation. Finally, some potential investigatory approaches are raised for solving the puzzles in AS pathogenesis.

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“…In the pathogenesis of AS, the dysregulation of the immune system can result in changes of mediators secreted by various immune cells, further causing the disturbance in bone metabolism (Madej et al, 2015; Sveaas et al, 2015). Immune cells, in particular of T cells, B cells, macrophages, and dendritic cells (DCs), are considered to be key factors of bone homeostasis (de Koning et al, 2018), which affects differently in the pathological progress of AS, as described in the following paragraphs.…”

Section: Osteoimmunological Mechanism Of Asmentioning

confidence: 99%

Osteoimmunological insights into the pathogenesis of ankylosing spondylitis

Liu

Yuan

Zhang

et al. 2021

Journal Cellular Physiology

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Ankylosing spondylitis (AS) is inflammatory arthritis predominantly affecting the spine, which is involved in the disorders of both immune and skeletal systems. The exact pathogenesis of AS is not fully understood. Osteoimmunology is a new subject of study in inflammatory arthritis, in particular the pathogenic events involved in the crossregulation of both skeletal and immune systems. In this review, we discuss osteoimmunological and pathological changes of AS in the spine that are characterized by altered osteogenesis and osteolytic bone destruction, accompanied by the changes of the immune system. It was revealed that bone cells like mesenchymal stem cells, osteoblast, and osteoclast in crossing talking with immune cells such as T cells, B cells coregulate to the pathogenesis of AS. Further, an array of cytokines and molecules expressed by both skeletal and immune systems contribute to these complex interplays. Understanding the cellular and molecular mechanisms underlying the pathogenesis of AS will lay a foundation for the exploration of the potential new treatment to AS.

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Cytokine profiles in axial spondyloarthritis

Cited by 20 publications

References 25 publications

Inflammatory bowel disease-related arthritis – clinical evaluation and possible role of cytokines

Inflammatory bowel disease-related arthritis – clinical evaluation and possible role of cytokines

The Potential Role of Genetics, Environmental Factors, and Gut Dysbiosis in the Aberrant Non-Coding RNA Expression to Mediate Inflammation and Osteoclastogenic/Osteogenic Differentiation in Ankylosing Spondylitis

Osteoimmunological insights into the pathogenesis of ankylosing spondylitis

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