Cytokine profile in the synovial fluid of patients with temporomandibular joint disorders: A systematic review

Kellesarian, Sergio Varela; Al‐Kheraif, Abdulaziz A.; Vohra, Fahim; Ghanem, Alexis; Malmström, Hans; Romanos, Georgios E.; Javed, Fawad

doi:10.1016/j.cyto.2015.11.005

Cited by 76 publications

(88 citation statements)

References 38 publications

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“…High levels of pro-inflammatory cytokines have been found in synovial fluid from OA patients and several models of cartilage degradation (Goldring and Otero, 2011[15]; Kellesarian et al, 2016[26]). Among these cytokines, IL-1β is highly over-expressed in the cartilage as well as in the synovial tissue while the expression of IL-1Rα, a receptor antagonist of the IL-1 family (Jotanovic et al, 2012[22]).…”

Section: Discussionmentioning

confidence: 99%

Schisandrae Fructus ethanol extract ameliorates inflammatory responses and articular cartilage damage in monosodium iodoacetate-induced osteoarthritis in rats

Jeong

Kim

Choi

et al. 2017

EXCLI Journal; 16:Doc265; ISSN 1611-2156

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Section: Discussionmentioning

confidence: 99%

Schisandrae Fructus ethanol extract ameliorates inflammatory responses and articular cartilage damage in monosodium iodoacetate-induced osteoarthritis in rats

Jeong

Kim

Choi

et al. 2017

EXCLI Journal; 16:Doc265; ISSN 1611-2156

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“…Raised levels of cytokines in the synovial fluid such as interleukin (IL)-6, tumour necrosis factor (TNF)-a, IL-1b, IL-8, and IFN-c have been associated with inflammation in patients with TMJ ID, [34] which may have something to do with pain and OA occurrence in TMJ. Certainly, clinical symptoms such as pain, locking, and limitation in mouth-opening are also important for the treatment of TMJ ID, which have not been investigated in this study and need further research.…”

Section: Discussionmentioning

confidence: 99%

Does condylar height decrease more in temporomandibular joint nonreducing disc displacement than reducing disc displacement?

Chen²,

Cai³

et al. 2016

Medicine

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The aim of the study was to compare condylar height changes of anterior disc displacement with reduction (ADDwR) and anterior disc displacement without reduction (ADDwoR) in temporomandibular joint (TMJ) quantitatively, to get a better understanding of the changes in condylar height of patients with anterior disc displacement who had received no treatment, and to provide useful information for treatment protocol. This longitudinal retrospective study enrolled 206 joints in 156 patients, which were divided into ADDWR group and ADDwoR group based on magnetic resonance imaging examination. The joints were assessed quantitatively for condylar height at initial and follow-up visits. Also, both groups were further divided into 3 subgroups according to age: <15 years group, 15 to 21 years group, and 22 to 35 years group. Paired t test and independent t test were used to assess intra- and intergroup differences. The average age of the ADDwR group was 19.65 years with a mean of 9.47 months’ follow-up. The follow-up interval of the patients with ADDwoR was 7.96 months, with a mean age of 18.51 years. Condylar height in ADDwoR tended to decrease more than those in ADDwR, especially during the pubertal growth spurt and with the presence of osteoarthrosis, meaning ADDwoR could cause a severe disturbance in mandibular development. Thus, an early disc repositioning was suggested to avoid decrease in condylar height.

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“…[30] Raised cytokine interleukin-8 production capacity is positively associated with severity of depressive disorders. [31] Both TMD and depressive disorders are related to higher levels of cytokines.…”

Section: Discussionmentioning

confidence: 99%

Dysthymia increases the risk of temporomandibular disorder

Lin

et al. 2016

Medicine

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Numerous studies have investigated the relationship between depression and temporomandibular disorders (TMD), but the conclusions remain vague. The aim of this study was to examine the causal effect between depression and TMD.The reporting of this study conforms to the STROBE statement. In this retrospective cohort study, all samples were recruited from a representative subdataset of 1 million insured persons for the year 2005 Longitudinal Health Insurance Database, who were randomly selected from all beneficiaries enrolled in the National Health Insurance program of Taiwan. We used a propensity score and stratified 926,560 patients into 2 groups (propensity1 = 588,429 and propensity2 = 338,131) and 4 cohorts (propensity1 with depression = 18,038, propensity1 without depression = 570,391, propensity2 with depression = 38,656, propensity2 without depression = 299,475) to detect the development of TMD among the depressive and nondepressive patients between 2004 and 2013.The positive correlative factors of TMD included female, total number of times seeking medical advice (TTSMA) for anxiety state, TTSMA for generalized anxiety disorder, TTSMA for mandible fracture, and TTSMA for unspecified anomaly of jaw size. The propensity2 group was represented by elder and female-predominant patients who used more psychiatric health resources. Among 3 types of depression, only dysthymia (so-called chronic depression) had a causal impact on TMD in the propensity 2 group. In the propensity 2 group, the hazard ratio of dysthymia for TMD measured by Cox's regression was 1.64 (95% confidence interval 1.28–2.09), after adjusting for demographic factors, psychiatric comorbidities, and maxillofacial confounders. The first-onset mean time of TMD as the consequence of dysthymia was 3.56 years (sd = 2.74, min = 0.08, median = 2.99, max = 9.73).This study demonstrates that dysthymia increases the risk of TMD in elderly and female-predominant patients who use more psychiatric health resources.

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Cytokine profile in the synovial fluid of patients with temporomandibular joint disorders: A systematic review

Cited by 76 publications

References 38 publications

Schisandrae Fructus ethanol extract ameliorates inflammatory responses and articular cartilage damage in monosodium iodoacetate-induced osteoarthritis in rats

Schisandrae Fructus ethanol extract ameliorates inflammatory responses and articular cartilage damage in monosodium iodoacetate-induced osteoarthritis in rats

Does condylar height decrease more in temporomandibular joint nonreducing disc displacement than reducing disc displacement?

Dysthymia increases the risk of temporomandibular disorder

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