Cytokine production in the infrapatellar fat pad: another source of cytokines in knee synovial fluids

Ushiyama, Toshio

doi:10.1136/ard.62.2.108

Cited by 194 publications

(145 citation statements)

References 22 publications

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“…The source of bFGF in the synovial fluid could stem from synovial cells and chondrocytes in local tissues (inflamed synovium, articular cartilage, subchondral bone) and extra-articular tissues. Previous studies have shown that bFGF is expressed in synovial cells, articular cartilage chondrocytes and infrapatellar fat pad in patients with OA [21,27,28]. Further studies are required to verify whether concentrations of bFGF in synovial fluid and plasma are related to local expression of bFGF in joint tissues.…”

Section: Discussionmentioning

confidence: 99%

Correlation between plasma and synovial fluid basic fibroblast growth factor with radiographic severity in primary knee osteoarthritis

Honsawek

Yuktanandana

Tanavalee

et al. 2011

International Orthopaedics (SICOT)

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Purpose The aim of this study was to investigate plasma and synovial fluid basic fibroblast growth factor (bFGF) levels in patients with primary knee osteoarthritis (OA) and to evaluate the correlation between bFGF levels and disease severity. Methods Thirty-five patients with knee OA and 15 healthy individuals were recruited into this study. Knee OA grading was performed according to the Kellgren-Lawrence classification. bFGF concentrations in both plasma and synovial fluid were determined using enzyme-linked immunosorbent assay. Results Plasma and synovial fluid bFGF levels in knee OA patients were significantly higher than in controls (P<0.001). Moreover, plasma and synovial fluid bFGF concentrations were positively correlated with radiographic severity (r0 0.535, P<0.001 and r00.570, P<0.001, respectively). Further analysis revealed that there was a positive correlation between plasma and synovial fluid bFGF levels (r00.674, P<0.001). Conclusions Plasma and synovial fluid bFGF levels were significantly increased in OA patients, and these elevated levels were positively correlated with radiographic severity.These findings indicate that bFGF levels may be a monitor of disease severity and could play an essential part in the pathophysiology of degenerative process in OA.

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Section: Discussionmentioning

confidence: 99%

Correlation between plasma and synovial fluid basic fibroblast growth factor with radiographic severity in primary knee osteoarthritis

Honsawek

Yuktanandana

Tanavalee

et al. 2011

International Orthopaedics (SICOT)

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“…This leads to differentiation into osteochondroma, which is however rare. 9 A study by Ushiyama et al 11 showed that this IFP has endocrine functions. It was found that cytokines involved in chondrocyte metabolism are produced in IFP, such as the basic fibroblast growth factor, vascular endothelial growth factor, tumor necrosis factor-alpha and interleukin-6.…”

Section: Discussionmentioning

confidence: 99%

“…Basic fibroblast growth factor and vascular endothelial growth factor, which have a specific mitogenic effect on endothelial cells, were identified to be also present in osteoarthritic cartilage tissue in humans. 11 They may change gene expression depending on environmental conditions. The IFP contains these root cells which can transform into adipocyte cells containing chylomicron and releasing leptin, chondrocyte cells synthesizing the cartilage matrix and osteoblast cells that mineralize, depending on environmental conditions.…”

Section: Discussionmentioning

confidence: 99%

Function of the Infrapatellar Fat Pad and Advanced Hoffa's Disease With Ossification

et al. 2014

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“…The infrapatellar fat pad contains nerve and immune cells (macrophages) capable of producing inflammatory and growth factors [7]. It may also contribute to the inflammatory processes in patellofemoral knee pain, knee osteoarthritis, and rheumatoid arthritis [1].…”

mentioning

confidence: 99%

CORR Insights®: The Effect of Infrapatellar Fat Pad Excision on Complications After Minimally Invasive TKA: A Randomized Controlled Trial

Bos

2013

Clin Orthop Relat Res

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Cytokine production in the infrapatellar fat pad: another source of cytokines in knee synovial fluids

Cited by 194 publications

References 22 publications

Correlation between plasma and synovial fluid basic fibroblast growth factor with radiographic severity in primary knee osteoarthritis

Correlation between plasma and synovial fluid basic fibroblast growth factor with radiographic severity in primary knee osteoarthritis

Function of the Infrapatellar Fat Pad and Advanced Hoffa's Disease With Ossification

CORR Insights®: The Effect of Infrapatellar Fat Pad Excision on Complications After Minimally Invasive TKA: A Randomized Controlled Trial

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