CYTOKINE PRODUCTION IN LINOMIDE-TREATED NOD MICE AND THE POTENTIAL ROLE OF A Th1/Th2 SHIFT ON AUTOIMMUNE AND ANTI-INFLAMMATORY PROCESSES

Weiss, Lola; Barak, Vivian; Zeira, Michael; Abdul-Hai, Ali; Raibstein, Israel; Reich, Shoshana; Hirschfeld, Esther; Gross, David J.; Slavin, Shimon

doi:10.1006/cyto.2002.1956

Cited by 24 publications

(25 citation statements)

References 37 publications

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“…Peritoneal macrophages were then harvested, and aliquots of the culture medium were subjected to ELISA analysis of IL-4, IL-10, IL-12, interferon-gamma (IFN-γ ) and TNF-α, as described [46].…”

Section: Cytokine Assaymentioning

confidence: 99%

“…Spleen lymphocytes (2.5-5.0 × 10 6 cells/mL) cultured in 75 mL flasks were stimulated for 24 h with rIL-2 (6000 IU/mL) in the absence and presence of heparanase in RPMI 1640 medium supplemented with 10% fetal calf serum (FCS). The culture supernatant was then subjected to ELISA analysis of IL-4, IL-10, IL-12, IFN-γ and TNF-α, as described [46].…”

Section: In Vitro Assaymentioning

confidence: 99%

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Heparanase prevents the development of type 1 diabetes in non‐obese diabetic mice by regulating T‐cell activation and cytokines production

Bitan

Weiss

Zeira

et al. 2008

Diabetes Metabolism Res

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Section: Cytokine Assaymentioning

confidence: 99%

Section: In Vitro Assaymentioning

confidence: 99%

Heparanase prevents the development of type 1 diabetes in non‐obese diabetic mice by regulating T‐cell activation and cytokines production

Bitan

Weiss

Zeira

et al. 2008

Diabetes Metabolism Res

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“…Body weight, water intake, and blood glucose of experimental mice (x l s) [17,18]. Low MG doses restored the CD4/CD8 ratio toward normal level by increasing the number of CD4 + lymphocyte subsets.…”

Section: Discussionmentioning

confidence: 99%

Effect of aSiraitia grosvenori extract containing mogrosides on the cellular immune system of type 1 diabetes mellitus mice

Xiang-yang¹,

Chen

Liu

et al. 2006

Mol. Nutr. Food Res.

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The purpose of this study was to observe the islet changes of pancreas in insulin-dependent diabetes mellitus (IDDM) mice in comparison to normal mice after application of an extract from Siraitia grosvenori fruits containing mogrosides, in particular, mogroside V. We hypothesized that mogroside extract (MG) attenuates the severity of alloxan-induced IDDM by effects on the immune system. Our data show that IDDM mice exhibited significant injury to pancreatic islets cells, which were atrophic. In addition, alloxan induced a notable increase in the expression of CD8+ lymphocytes to form a dramatic decrease in CD4+/CD8+ ratio (while CD4+ was unchanged). MG, administered to normal and experimental diabetic mice for 4 wk, effectively attenuated the early clinical symptoms, biochemical abnormalities, and pathological damages in pancreatic islets. Furthermore, at low dose, MG regulated the immune imbalance observed in alloxan-induced IDDM mice by up-regulating the CD4+ T-lymphocyte subsets and CD4/CD8 ratio, and altering the intracellular cytokine profiles. The expression of the pro-inflammatory Th1 cytokines: IFN-gamma, TNF-alpha in splenic lymphocytes was altered toward a beneficial Th2 pattern. MG therapy had no effect on normal mice, except that low dosage MG could up-regulate the IL-4 expression levels. The results revealed that MG exhibited antidiabetic effects presumably due to the presence of mogrosides.

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“…It has been shown to be effective in preventing clinical and histologic manifestations of autoimmunity in murine models of collagen type II-induced arthritis [1], experimental allergic encephalomyelitis (EAE) [2][3][4][5], experimental autoimmune neuritis (EAN) [6], and autoimmune insulitis and diabetes in non-obese diabetic (NOD) mice [7][8][9]. Linomide has also been found to prevent systemic lupus erythematosus (SLE)-like disease in MRL/lpr and NZB/NZW mice [10,11].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of linomide on lipopolysaccharide-induced proinflammatory cytokine tumor necrosis factor-alpha production in RAW264.7 macrophages through suppression of NF-κB, p38, and JNK activation

Xiao¹,

Zhou²,

Zhang³

et al. 2007

Immunology Letters

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CYTOKINE PRODUCTION IN LINOMIDE-TREATED NOD MICE AND THE POTENTIAL ROLE OF A Th1/Th2 SHIFT ON AUTOIMMUNE AND ANTI-INFLAMMATORY PROCESSES

Cited by 24 publications

References 37 publications

Heparanase prevents the development of type 1 diabetes in non‐obese diabetic mice by regulating T‐cell activation and cytokines production

Heparanase prevents the development of type 1 diabetes in non‐obese diabetic mice by regulating T‐cell activation and cytokines production

Effect of aSiraitia grosvenori extract containing mogrosides on the cellular immune system of type 1 diabetes mellitus mice

Inhibitory effect of linomide on lipopolysaccharide-induced proinflammatory cytokine tumor necrosis factor-alpha production in RAW264.7 macrophages through suppression of NF-κB, p38, and JNK activation

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