Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma

History of infections and vaccinations and risk of lymphoid neoplasms: does influenza immunization reduce the risk?

“…7 Repeated vaccinations could imbalance in the regulation and expression of Th1 and Th2 cytokines towards a Th1 thought to be protective against cancer. A shift in the balance of the Th1/Th2 response may play a role in aetiology of LNs as suggested by Holly et al 8 This hypothesis is also supported by recent findings that genetic variation in two key genes of Th2 pathway (IL-10, IL-4) could be associated with NHL.…”

The non-Hodgkin lymphomas: A review of the epidemiologic literature

“…The positive association with genetic variation in IL10 was also found independently in one of the US studies included in the pooled analysis. 482 Genes involved in the folate metabolism and transport pathway, which affects DNA synthesis and methylation, have been examined in a few NHL case-control studies. [483][484][485][486] Although results are not entirely consistent, findings from these studies suggest that genetic variation in methionine synthase and thymidylate synthase are associated with risk of NHL.…”

Gene polymorphisms in Toll-like receptors, interleukin-10, and interleukin-10 receptor alpha and lymphoma risk

“…26 Some studies have suggested a role of genetic variants in IL10 in lymphoma aetiology and prognosis. [27][28][29][30] We hypothesized that these factors at the interphase between environment and immune system and important players in inflammatory processes are implicated in lymphomagenesis. Specifically, within our populationbased case-control study on lymphoid neoplasms involving 710 case-control pairs 5,8 we have explored the contribution of putative functional polymorphisms in TLR1, TLR2, TLR4, TLR5, TLR9, IL10 and interleukin-10 receptor alpha (IL10RA) to inter-individual differences in the susceptibility to lymphoma and lymphoma subtypes ( Table 2).…”