Cytokine pattern in very early rheumatoid arthritis favours B cell activation and survival

Moura, Rita A; Cascão, Rita; Perpétuo, I.P.; Canhão, Helena; Sousa, E; Mourão, AF; Polido-Pereira, Joaquim; Queiróz, M Viana; Rosário, H S; Souto-Carneiro, M M; Graça, Luís

doi:10.1186/1479-5876-8-s1-p33

Cited by 15 publications

(26 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…APRIL shares similar functions with BAFF, but the precise biological role of APRIL in immune cell development and regulation requires further clarification [6][7][8]. The results on serum BAFF levels in our patients with RA did not fit completely with those of previous studies [29,30]. In fact, we observed an increase in BAFF levels in RA patients as compared to AS and HC, although this increase was not significant.…”

Section: Discussioncontrasting

confidence: 38%

“…As discussed above, high levels of these soluble factors have been described in patients with RA [29] or very early RA [30] or in other autoimmune diseases [29,31,32]. Since BAFF levels per B cell have been determined in murine models to be critical in autoreactive B cell survival [14,15], and a decrease in B cells characterized patients with RA, it seems more relevant to evaluate the BAFF/B cell ratio rather than circulating BAFF.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Peripheral Blood B cell Subsets and BAFF/APRIL Levels and their Receptors are Disturbed in Rheumatoid Arthritis but not in Ankylosing Spondylitis

Laheurte¹

2013

J Clin Cell Immunol

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 38%

Section: Discussionmentioning

confidence: 99%

Peripheral Blood B cell Subsets and BAFF/APRIL Levels and their Receptors are Disturbed in Rheumatoid Arthritis but not in Ankylosing Spondylitis

Laheurte¹

2013

J Clin Cell Immunol

View full text Add to dashboard Cite

“…To beter understand the relevance of BAFF/BAFF receptor system in the complex pathobiology of RA with direct involvement in both early stages and disease progression, we emphasized several aspects regarding cell networking and BAFF inluences, BAFF levels, and BAFF receptor expression in RA [2,4,[15][16][17][18][19][20][21][22][23][24].…”

Section: Baff and Baff Receptors In Rheumatoid Arthritismentioning

confidence: 99%

“…Abundant BAFF levels further support a positive feedback from B-lymphocytes, the BAFF/ BAFF-R signaling being an important stimulator of B-cell proliferation, survival, and activation, with subsequent dysregulated B-cell functioning, with synthesis of various cytokines, and autoantibodies [1][2][3][4][14][15][16][17][18][19][20][21][22][23][24].…”

Section: Neutrophils Macrophages Dendritic Cells and B-lymphocyte mentioning

confidence: 99%

“…Dysregulated BAFF/BAFF receptor signaling is clearly a trigger for autoimmunity in particular setings as is the case of systemic lupus erythematosus and RA [1,2,4,5,[15][16][17][18][19][20][21][22][23][24]. To beter understand the relevance of BAFF/BAFF receptor system in the complex pathobiology of RA with direct involvement in both early stages and disease progression, we emphasized several aspects regarding cell networking and BAFF inluences, BAFF levels, and BAFF receptor expression in RA [2,4,[15][16][17][18][19][20][21][22][23][24].…”

Section: Baff and Baff Receptors In Rheumatoid Arthritismentioning

confidence: 99%

See 1 more Smart Citation

BAFF System in Rheumatoid Arthritis: from Pathobiology to Therapeutic Targets

Ancuţa¹,

Pomirleanu²,

Mihailov³

et al. 2017

New Developments in the Pathogenesis of Rheumatoid Arthritis

View full text Add to dashboard Cite

Recent advances in understanding the multifaceted pathobiology of rheumatoid arthritis have highlighted the pivotal role and continuing crosstalk between activated immune cells, pro-inlammatory cytokines, and matrix-degrading mediators, promoting chronic inlammation as well as irreversible tissue damage within an autoimmune background.B cells are widely recognized as leading players in immune-mediated pathology based on their ability to produce not only diferent paterns of autoantibodies and driving cyto-

show abstract

The role of BAFF and APRIL in rheumatoid arthritis

Shabgah

Sarabi

Tavakkol‐Afshari

et al. 2019

Journal Cellular Physiology

View full text Add to dashboard Cite

Development and activation of B cells quickly became clear after identifying new ligands and receptors in the tumor necrosis factor superfamily. B cell–activating factor (BAFF) and a proliferation‐inducing ligand (APRIL) are the members of membrane proteins Type 2 family released by proteolytic cleavage of furin to form active, soluble homotrimers. Except for B cells, ligands are expressed by all such immune cells like T cells, dendritic cells, monocytes, and macrophages. BAFF and APRIL have two common receptors, namely TNFR homolog transmembrane activator and Ca2+ modulator and CAML interactor (TACI) and B cell–maturation antigen. BAFF alone can also be coupled with a third receptor called BAFFR (also called BR3 or BLyS Receptor). These receptors are often expressed by immune cells in the B‐cell lineage. The binding of BAFF or APRIL to their receptors supports B cells differentiation and proliferation, immunoglobulin production and the upregulation of B cell–effector molecules expression. It is possible that the overexpression of BAFF and APRIL contributes to the pathogenesis of autoimmune diseases. In BAFF transgenic mice, there is a pseudo‐autoimmune manifestation, which is associated with an increase in B‐lymphocytes, hyperglobulinemia, anti‐single stranded DNA, and anti‐double‐stranded DNA antibodies, and immune complexes in their peripheral blood. Furthermore, overexpressing BAFF augments the number of peripheral B220+ B cells with a normal proliferation rate, high levels of Bcl2, and prolonged survival and hyperactivity. Therefore, in this review article, we studied BAFF and APRIL as important mediators in B‐cell and discussed their role in rheumatoid arthritis.

show abstract

Cytokine pattern in very early rheumatoid arthritis favours B cell activation and survival

Cited by 15 publications

References 0 publications

Peripheral Blood B cell Subsets and BAFF/APRIL Levels and their Receptors are Disturbed in Rheumatoid Arthritis but not in Ankylosing Spondylitis

Peripheral Blood B cell Subsets and BAFF/APRIL Levels and their Receptors are Disturbed in Rheumatoid Arthritis but not in Ankylosing Spondylitis

BAFF System in Rheumatoid Arthritis: from Pathobiology to Therapeutic Targets

The role of BAFF and APRIL in rheumatoid arthritis

Contact Info

Product

Resources

About