Cytokine Network of Eutopic and Ectopic Endometrium in Women with Adenomyosis

Sotnikova, N. Yu.; Анциферова, І.В.; Малышкина, А. И.

doi:10.1034/j.1600-0897.2002.01040.x

Cited by 48 publications

(33 citation statements)

References 16 publications

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“…Adenomyosis, ectopic endometrium within the myometrium, is characterized by unique patterns of cytokine balance when compared with normal endometrium. 36 Adenomyosis is known to have increased secretions of interferon (IFN)-a, IFN-c, tumor necrosis factor (TNF)-a, and interleukin (IL)-10. 36,37 Increased level of these cytokines may potentially augment the cancer-immune system (IFN-a and IFN-c), anti-tumor effect via enhancing apoptosis (TNF-a), and anti-inflammatory cytokine production (IL-10), resulting in protective effects to endometrial cancer progression.…”

Section: Discussionmentioning

confidence: 99%

“…36 Adenomyosis is known to have increased secretions of interferon (IFN)-a, IFN-c, tumor necrosis factor (TNF)-a, and interleukin (IL)-10. 36,37 Increased level of these cytokines may potentially augment the cancer-immune system (IFN-a and IFN-c), anti-tumor effect via enhancing apoptosis (TNF-a), and anti-inflammatory cytokine production (IL-10), resulting in protective effects to endometrial cancer progression. [38][39][40][41] Adenomyosis is also known to have decreased secretions of various cytokines such as IL-1b, IL-8, and epidermal growth factor (EGF).…”

Section: Discussionmentioning

confidence: 99%

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Significance of Adenomyosis on Tumor Progression and Survival Outcome of Endometrial Cancer

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Significance of Adenomyosis on Tumor Progression and Survival Outcome of Endometrial Cancer

et al. 2014

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“…Yang et al (32) reported that abnormal secretion of IL-6 and IL-8 from endometrial stromal cells may have a role in the formation of ectopic islands in adenomyosis. Furthermore, the role of EGF, VEGF and TGF-β implicated in inflammation, angiogenesis and the pathophysiology of endometriosis has been well established (36)(37)(38). Cell invasion is a vital hallmark of tumor formation and progression.…”

Section: Discussionmentioning

confidence: 99%

Berberine inhibits the LPS‑induced proliferation and inflammatory response of stromal cells of adenomyosis tissues mediated by the LPS/TLR4 signaling pathway

et al. 2017

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Abstract.A previous study by our group has demonstrated that lipopolysaccharide (LPS) induces adenomyosis through stimulating inflammatory cell proliferation and invasive growth of stromal cells via Toll-like receptor 4 (TLR4) signaling. The present study aimed to investigate the effects of berberine (BBR) on LPS-induced ectopic endometrial stromal cells (EESCs) isolated from patients with adenomyosis. The viability of EESCs treated with LPS or LPS plus BBR was detected by a cell counting kit-8 assay, and the cell cycle distribution and apoptosis were evaluated by flow cytometry. The effect of BBR on the expression of key molecules of inflammatory proliferation and invasive growth of LPS-induced EESCs was also evaluated. BBR significantly inhibited the LPS-induced proliferation of EESCs in a dose-and time-dependent manner. BBR induced cell cycle arrest in G0/G1 phase and enhanced apoptosis of LPS-induced EESCs. Furthermore, BBR inhibited the expression of interleukin (IL)-6, IL-8, transforming growth factor-β, epithelial growth factor, vascular endothelial growth factor and matrix metalloproteinase 2 in LPS-induced EESCs. To the best of our knowledge, the present study was the first to demonstrate that BBR has a protective effect on ameliorating the LPS-induced progression of adenomyosis. This result may provide a novel therapeutic strategy for the clinical treatment of the disease.

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“…16,17 In contrast, adenomyosis impairs the function of the myometrium. A recent report showed a significant increase in the myometrial stiffness (estimated with shear wave elastography) in patients with adenomyosis.…”

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confidence: 99%

Complications and outcomes of pregnant women with adenomyosis in Japan

Tamura

Maekawa

Sugino

2018

Fertility and Sterility

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Purpose: To investigate the impact of adenomyosis on the complications and outcomes of pregnancy in Japan. Methods:We carried out a multicenter retrospective questionnaire survey. A questionnaire regarding pregnancy complications and the outcomes of pregnancy was sent to 725 facilities.Results: Data were obtained on the cases of 272 pregnant women with adenomyosis from 65 facilities. The complications of pregnancy included miscarriage before 12 weeks of pregnancy (14.8%), miscarriage after 12 weeks of pregnancy (9.9%), preterm delivery (24.4%), fetal growth restriction (11.8%), pregnancy-induced hypertension (9.9%), intrauterine infection (7.3%), and cervical incompetency (5.3%). The rates of pregnancy complications in the three groups classified according to pretreatment for adenomyosis (no pretreatment, medication, surgery) did not differ to a statistically significant extent. The rates of miscarriage (>12 weeks) and cervical incompetency increased according to the size of the adenomyosis. The rates of pregnancy-induced hypertension and uterine infection in patients with diffuse-type adenomyosis were higher than that in patients with focal-type adenomyosis. Conclusions:Our results show that the increased size and diffuse type of adenomyosis are associated with adverse pregnancy outcome. We should be aware of the higher incidence of pregnancy-induced hypertension and uterine infection in patients with diffuse-type adenomyosis. K E Y W O R D Sadenomyosis, complication, miscarriage, pregnancy, preterm delivery

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Cytokine Network of Eutopic and Ectopic Endometrium in Women with Adenomyosis

Abstract: The results obtained indicate a significant role of local cytokine production impairment in the development of adenomyosis.

Cited by 48 publications

References 16 publications

Significance of Adenomyosis on Tumor Progression and Survival Outcome of Endometrial Cancer

Significance of Adenomyosis on Tumor Progression and Survival Outcome of Endometrial Cancer

Berberine inhibits the LPS‑induced proliferation and inflammatory response of stromal cells of adenomyosis tissues mediated by the LPS/TLR4 signaling pathway

Complications and outcomes of pregnant women with adenomyosis in Japan

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