Cytokine modulation of epidermal growth factor receptor expression on bladder cancer cells is not a major contributor to the antitumour activity of cytokines

Alexandroff, A.B.; Jackson, Andrew M.; Chisholm, G. D.; James, Keith

doi:10.1016/0959-8049(95)00210-3

Cited by 8 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Its effect is mediated via a bispecific receptor, the EGF receptor (EGFR), whose expression correlates well with invasive bladder cancer. The proteins interferon-gamma, tumor necrosis factor-alpha, and IL-1α can decrease the expression of EGFR in some bladder tumor cell lines, thus inhibiting invasive tumor (Alexandroff et al, 1995). Toll-like receptor 4 (TLR4) and B7-H1, which are known from previous studies to be restricted to immune cells, are found to be aberrantly expressed in a bladder cancer, facilitating tumor evasion from immune surveillance and tumor progression.…”

Section: Discussionmentioning

confidence: 99%

Gene expression profile and enrichment pathways in different stages of bladder cancer

Fang

Zang²,

Chen³

et al. 2013

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Bladder cancer is a highly heterogeneous neoplasm. We examined the gene expression profile in 3 bladder cancer stages (Ta, T1, T2) using expression microarray analysis of 40 bladder tumors. Differentially expressed genes were found by the t-test, with <0.005 as the significance threshold. KEGG pathway-enrichment analysis was used to study the signaling pathways of the genes. We found 36 genes that could be used as molecular markers for predicting the transition from Ta-T1 to T1-T2. Among these, 11 overlapped between Ta-T1 and T1-T2 stages. Six genes were downregulated at the Ta-T1 stage, but were up-regulated at the T1-T2 stage (ANXA5, ATP6V1B2, CTGF, GEM, IL13RA1, and LCP1); 5 genes were up-regulated at the Ta-T1 stage, but down-regulated at the T1-T2 stage (ACPP, GNL1, RIPK1, RAPGEF3, and ZER1). Another 25 genes changed relative expression levels at the T1-T2 stage. These genes (including COL1A1, COL1A2, FN1, ITGA5, LGALS1, SPP1, VIM, POSTN, and COL18A1) may be involved in bladder cancer progression by affecting extracellular matrix-receptor interaction and focal adhesion. The cytokine-cytokine receptor interaction, neuroactive ligandreceptor interaction, and calcium-signaling pathway were associated with bladder cancer progression at both the Ta-T1 and T1-T2 stages.

show abstract

Section: Discussionmentioning

confidence: 99%

Gene expression profile and enrichment pathways in different stages of bladder cancer

Fang

Zang²,

Chen³

et al. 2013

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

“…With regard to the infectious complications of URS lithotripsy, there are certain serum markers including pro-inflammatory cytokines that are gaining importance in clinical practice [ 3 – 5 ]. Cytokines are a group of peptides that regulate the humoral and cellular components of the immune system and in vivo inflammatory responses.…”

Section: Introductionmentioning

confidence: 99%

Can Tumor Necrosis Factor-αand Interleukin-6 Be Used as Prognostic Markers of Infection following Ureteroscopic Lithotripsy?

et al. 2014

View full text Add to dashboard Cite

Introduction. Ureteroscopic lithotripsy (URS) although highly effective for the treatment of ureteral stones is associated with certain complications, the more common of which are postoperative fever and infection. In the present study we aimed to evaluate the levels of serum cytokines in patients undergoing ureteroscopic lithotripsy and investigate any possible correlation between levels of cytokines and infectious complications after URS. Materials and Methods. Thirty patients (19 males, 11 females), with a mean age of 47 (range: 26–68) that underwent URS lithotripsy for ureteral stones, and 10 healthy volunteers serving as the control group were enrolled in this study. Serum samples for TNF-α and IL-6 were obtained before surgical intervention and after 1, 24, and 48 hours and 2 , 24, and 48 hours, respectively. The preoperative and postoperative levels were compared and correlated with the possible complications after URS. Results. Serum TNF-α levels were statistically significant, increased 1 hour (P = 0.0083) and 48 hours (P < 0.001) after operation. IL-6 levels were found statistically significant, elevated after 2 and 24 hours from the URS (P < 0.001). In 2 patients we observed postoperative fever (>38.5°C). These two patients had high preoperative values of TNF-α and IL-6 ( 30 and 50 pg/mL, resp.) and these values increased postoperatively. Conclusion. High preoperative levels of serum TNF-α and IL-6 may indicate a predisposition for postoperative inflammation and infection following URS lithotripsy.

show abstract

Evaluation of urinary IL-1α and IL-1β in gravid females and patients with bacterial cystitis and microscopic hematuria

Candela

Park

Gerspach

et al. 1998

Urological Research

View full text Add to dashboard Cite

Significant elevations of IL-1alpha and IL-1beta occur in patients with bacterial cystitis and microscopic hematuria. Correlation between pyuria and cytokine elevation was stronger for IL-1beta than for IL-1alpha. Changes in IL-1alpha may reflect changes in the bladder epithelium rather than in the inflammatory leukocytes. The ability of IL-1alpha and IL-1beta to serve as markers for bacterial cystitis in gravid females is diminished due to high basal levels during pregnancy.

show abstract

Cytokine modulation of epidermal growth factor receptor expression on bladder cancer cells is not a major contributor to the antitumour activity of cytokines

Cited by 8 publications

References 25 publications

Gene expression profile and enrichment pathways in different stages of bladder cancer

Gene expression profile and enrichment pathways in different stages of bladder cancer

Can Tumor Necrosis Factor-αand Interleukin-6 Be Used as Prognostic Markers of Infection following Ureteroscopic Lithotripsy?

Evaluation of urinary IL-1α and IL-1β in gravid females and patients with bacterial cystitis and microscopic hematuria

Contact Info

Product

Resources

About